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Interleukin-4 induces foreign body giant cells from human monocytes/macrophages: Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells
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Role for interleukin-4 in foreign-body giant cell formation on a poly(etherurethane urea) in vivo
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2 Kao WJ, McNally AK, Hiltner A, Anderson JM: Role for interleukin-4 in foreign-body giant cell formation on a poly(etherurethane urea) in vivo. J Biomed Mater Res 1995, 29:1267-1276.
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Formation of multi-nucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation
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3 Möst J, Spötl L, Mayr G, Gasser A, Sarti A, Dierich MP: Formation of multi-nucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation. Blood 1997, 89:662-671.
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Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression
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4 DeFife KM, McNally AK, Colton E, Anderson JM: Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression. J Immunol 1997, 158:319-328.
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Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity
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Human monocyte/macrophage adhesion, macrophage motility, and IL-4-induced foreign body giant cell formation on silane-modified surfaces in vitro
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6 Jenney CR, DeFife KM, Colton E, Anderson JM: Human monocyte/macrophage adhesion, macrophage motility, and IL-4-induced foreign body giant cell formation on silane-modified surfaces in vitro. J Biomed Mater Res 1998, 41:171-184.
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Effects of photochemically immobilized polymer coatings on protein adsorption, cell adhesion and the foreign body reaction to silicone rubber
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7 DeFife KM, Shive MS, Hagen KM, Clapper DL, Anderson JM: Effects of photochemically immobilized polymer coatings on protein adsorption, cell adhesion and the foreign body reaction to silicone rubber. J Biomed Mater Res 1999, 44:298-307.
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Effects of surface-coupled polyethylene oxide on human macrophage adhesion and foreign body giant cell formation in vitro
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8 Jenney CR, Anderson JM: Effects of surface-coupled polyethylene oxide on human macrophage adhesion and foreign body giant cell formation in vitro. J Biomed Mater Res 1998, 44:206-216.
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Spatial regulation and surface chemistry control of monocyte/rnacrophage adhesion and foreign body giant cell formation by photochemically micropatterned surfaces
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9 DeFife KM, Colton E, Nakayama Y, Matsuda T, Anderson JM: Spatial regulation and surface chemistry control of monocyte/rnacrophage adhesion and foreign body giant cell formation by photochemically micropatterned surfaces. J Biomed Mater Res 1999, 45:148-154.
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Aikylsilane-modified surfaces: Inhibition of human macrophage adhesion and foreign body giant cell formation
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10 Jenney CR, Anderson JM: Aikylsilane-modified surfaces: inhibition of human macrophage adhesion and foreign body giant cell formation. J Biomed Mater Res 1999,46:11-21. Utilizing the interleukin-4 culture system, tetradecyl (C14) and octadecyl (C18) silane-modified surfaces inhibited human macrophage formation and FBGC formation. Hexyl (C6) surfaces maintained a high macrophage density and permitted interleukin-4-induced FBGC formation. Clean glass surfaces also supported high levels of macrophage adhesion but inhibited interleukin-4-induced FBGC formation.
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Jenney, C.R.1
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Cytoskeletal and adhesive structural polarizations accompany IL-13-induced human macrophage fusion
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11 DeFife KM, Jenney CR, Colton E, Anderson JM: Cytoskeletal and adhesive structural polarizations accompany IL-13-induced human macrophage fusion. J Histochem Cylochem 1999, 47:65-74. Punctate filamentous F-actin structures were identified on the ventral cell membrane of macrophages as the core of podosome adhesive structures by the distinctive ring staining of vinculin, talin, and paxillin around the F-actin. Cytokine-induced FBGCs were characterized by a restriction of podosomal adhesive structures to the extreme periphery of the ventral cell surface.
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Disruption of filamentous actin inhibits human macrophage fusion
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Multinucleated giant cell formation induced by IFN-γ/IL-3 is associated with restriction of virulent mycobacterium tuberculosis cell to cell invasion in human monocyte monolayers
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14 Byrd TF: Multinucleated giant cell formation induced by IFN-γ/IL-3 is associated with restriction of virulent Mycobacterium tuberculosis cell to cell invasion in human monocyte monolayers. Cell Immunol 1998, 188:89-96. Interferon-γ and interleukin-3 promoted Langhans'-type multinucleated giant cell formation. These Langhans'-type multinucleated giant cells were observed to isolate and restrict the growth of M. tuberculosis.
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Multinucleated giant cells generation induced by interferon-γ: Changes in the expression and distribution of the intercellular adhesion molecule-1 during macrophage fusion and multinucleated giant cell formation
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15 Fais S, Burgio VL, Silvestri M, Capobianchi MR, Pacchiarotti A, Pallone F: Multinucleated giant cells generation induced by interferon-γ: changes in the expression and distribution of the intercellular adhesion molecule-1 during macrophage fusion and multinucleated giant cell formation. Lab Invest 1994, 71:737-744.
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Generation of multinucleated giant cells in vitro by culture of human monocytes with mycobacterium bovis BCG in combination with cytokine-containing supernatants
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16 Gasser A, Möst J: Generation of multinucleated giant cells in vitro by culture of human monocytes with Mycobacterium bovis BCG in combination with cytokine-containing supernatants. Infect Immun 1999, 67:395-402. Monocytes in contact with mycobacteria and in the presence of cytokine-containing supernatants can induce monocytes to form multinucleated giant cells, and membrane-bound molecules of mycobacteria and monocytes are involved in the fusion process. Giant cell formation in this system could be inhibited by monoclonal antibodies to interferon-γ and the β-chain (CD18) of β2-integrins.
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Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells
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19 Jimi E, Nakamura I, Duong LT, Ikebe T, Takahashi N, Rodan GA, Suda T: Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells. Exp Cell Res 1999, 247:84-93.
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A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function
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The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
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Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival
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Role of the leukocyte function antigen-1 conformational state in the process of human immunodeficiency virus type 1-mediated syncytium formation and virus infection
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