Inhibitory influences of xanthine oxidase inhibitor and angiotensin I-converting enzyme inhibitor on multinucleated giant cell formation from monocytes by downregulation of adhesion molecules and purinergic receptors

British Journal of Dermatology

Volumn 150, Issue 2, 2004, Pages 205-210

  Mizuno, K ^a   Okamoto, H ^a   Horio, T ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Intercellular adhesion molecule 1; Monocytes; P2X7 receptor; Sarcoidosis; Tranilast

Indexed keywords

2' [2 (4 BENZOYLBENZOYL)]ADENOSINE TRIPHOSPHATE; 3' [2 (4 BENZOYLBENZOYL)]ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ALLOPURINOL; CAPTOPRIL; CELL ADHESION MOLECULE; CONCANAVALIN A; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; PURINE P2X7 RECEPTOR; PURINE RECEPTOR; TRANILAST; UNCLASSIFIED DRUG; XANTHINE OXIDASE INHIBITOR;

ARTICLE; CELL CULTURE; CELL LINEAGE; CONTROLLED STUDY; CYTOLYSIS; DOWN REGULATION; DRUG EFFECT; GIANT CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPERNATANT;

ALLOPURINOL; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CAPTOPRIL; CELL ADHESION MOLECULES; CELLS, CULTURED; DOWN-REGULATION; ENZYME INHIBITORS; GIANT CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MONOCYTES; RECEPTORS, PURINERGIC; XANTHINE OXIDASE;

EID: 1542507085     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2004.05768.x     Document Type: Article

References (28)

1. Yamada H, Ide A, Sugiura M, Tajima S. Treatment of cutaneous sarcoidosis with tranilast. J Dermatol 1995; 22: 149-52.
2. El-Euch D, Mokni M, Trojjet S et al. Sarcoidosis in a child treated successfully with allopurinol. Br J Dermatol 1999; 140: 1184-5.
3. Antony F, Layton AMA. case of cutaneous acral sarcoidosis with response to allopurinol. Br J Dermatol 2000; 142: 1052-3.
4. Veien NK. Cutaneous sarcoidosis: prognosis and treatment. Clin Dermatol 1986; 4: 75-87.
5. Lieberman J, Zakria F. Effect of captopril and enalapril medication on the serum ACE test for sarcoidosis. Sarcoidosis 1989; 6: 118-23.
6. Lieberman J. Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis. Am J Med 1975; 59: 365-72.
7. Silverstein E, Friedland J, Lyons HA, Gourin A. Markedly elevated angiotensin converting enzyme in lymph nodes containing non-necrotizing granulomas in sarcoidosis. Proc Natl Acad Sci USA 1976; 73: 2137-41.
8. Silverstein E, Pertschuk LP, Friedland J. Immunofluorescent localization of angiotensin converting enzyme in epithelioid and giant cells of sarcoidosis granulomas. Proc Natl Acad Sci USA 1979; 76: 6646-8.
9. Okabe T, Yamagata K, Fujisawa M et al. Increased angiotensin-converting enzyme in peripheral blood monocytes from patients with sarcoidosis. J Clin Invest 1985; 75: 911-14.
10. Weinstock JV, Boros DL, Gee JB, Ehrinpreis MN. The effect of SQ 14225, an inhibitor of angiotensin I converting enzyme, on the granulomatous response to Schistosoma mansoni eggs in mice. J Clin Invest 1981; 67: 931-6.
11. Weinstock JV, Boros DL, Gee JB. Enhanced granuloma angiotensin I converting enzyme activity associated with modulation in murine schistosomiasis. Gastroenterology 1981; 81: 48-53.
12. Gondo A, Saeki N, Yamamoto E et al. Efficacy of tranilast administration and specific hyposensitization therapy of atopic dermatitis. Arerugi 1985; 34: 310-19 (in Japanese).
13. Yamada H, Ide A, Sugiura M et al. Treatment of granuloma annulare with tranilast. J Dermatol 1995; 22: 354-6.
14. Mizuno K, Okamoto H, Horio T. Inhibitory influence of tranilast on multinucleated giant cell formation from monocytes by supernatant of concanavalin A-stimulated mononuclear cells. J Dermatol Sci 2000; 24: 166-70.
15. McInnes A, Rennick DM. Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells. J Exp Med 1988; 167: 598-611.
16. Ikeda T, Ikeda K, Sasaki K et al. IL-13 as well as IL-4 induces monocytes/macrophages and a monoblastic cell line (UG3) to differentiate into multinucleated giant cells in the presence of M-CSF. Biochem Biophys Res Commun 1998; 253: 265-72.
17. Enelow RI, Sullivan GW, Carper HT, Mandell GL. Induction of multinucleated giant cell formation from in vitro culture of human monocytes with interleukin-3 and interferon-γ: comparison with other stimulating factors. Am J Respir Cell Mol Biol 1992; 6: 57-62.
18. Möst J, Spötl L, Mayr G et al. Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation. Blood 1997; 89: 662-71.
19. Falzoni S, Munerati M, Ferrari D et al. The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. J Clin Invest 1995; 95: 1207-16.
20. Di Virgilio F, Falzoni S, Chiozzi P et al. ATP receptors and giant cell formation. J Leuk Biol 1999; 66: 723-6.
21. Mizuno K, Okamoto H, Horio T. Heightened ability of monocytes from sarcoidosis patients to form multi-nucleated giant cells in vitro by supernatants of concanavalin A-stimulated mononuclear cells. Clin Exp Immunol 2001; 126: 151-6.
22. Wroblewski F, John SL. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med 1955; 90: 210-13.
23. Buell G, Chessell IP, Michel AD et al. Blockade of human P2X7 receptor function with a monoclonal antibody. Blood 1998; 92: 3521-8.
24. Humphreys BD, Dubyak GR. Modulation of P2X7 nucleotide receptor expression by pro-and anti-inflammatory stimuli in THP-1 monocytes. J Leukoc Biol 1998; 64: 265-73.
25. Fais S, Pallone F. Inability of normal human intestinal macrophages to form multinucleated giant cells in response to cytokines. Gut 1995; 37: 798-801.
26. Kazazi F, Chang J, Lopez A et al. Interleukin 4 and human immunodeficiency virus stimulate LFA-1-ICAM-1-mediated aggregation of monocytes and subsequent giant cell formation. J Gen Virol 1994; 75: 2795-802.
27. Fais S, Burgio VL, Silvestri M et al. Multinucleated giant cells generation induced by interferon-γ. Changes in the expression and distribution of the intercellular adhesion molecule-1 during macrophages fusion and multinucleated giant cell formation. Lab Invest 1994; 71: 737-44.
28. 7 receptor: a pivotal role in inflammation and immunomodulation. Drug Dev Res 1999; 45: 207-13.