-
1
-
-
2342540450
-
Nuclear export inhibitors and kinase inhibitors identified using a MAPK-activated protein kinase 2 redistribution screen
-
Almholt D.L., Loechel F., Nielsen S.J., Krog-Jensen C., Terry R., Bjorn S.P., Pedersen H.C., Praestegaard M., Moller S., Heide M., Pagliaro L., Mason A.J., Butcher S., and Dahl S.W. Nuclear export inhibitors and kinase inhibitors identified using a MAPK-activated protein kinase 2 redistribution screen. Assay Drug Dev. Technol. 2 (2004) 7-20
-
(2004)
Assay Drug Dev. Technol.
, vol.2
, pp. 7-20
-
-
Almholt, D.L.1
Loechel, F.2
Nielsen, S.J.3
Krog-Jensen, C.4
Terry, R.5
Bjorn, S.P.6
Pedersen, H.C.7
Praestegaard, M.8
Moller, S.9
Heide, M.10
Pagliaro, L.11
Mason, A.J.12
Butcher, S.13
Dahl, S.W.14
-
2
-
-
0037389558
-
Mitogen-activated protein kinases: New signaling pathways functioning in cellular responses to environmental stress
-
Cowan K.J., and Storey K.B. Mitogen-activated protein kinases: New signaling pathways functioning in cellular responses to environmental stress. J. Exp. Biol. 206 (2003) 1107-1115
-
(2003)
J. Exp. Biol.
, vol.206
, pp. 1107-1115
-
-
Cowan, K.J.1
Storey, K.B.2
-
3
-
-
0023433311
-
Five-parameter fluorescence imaging: Wound healing of living Swiss 3T3 cells
-
DeBiasio R., Bright G.R., Ernst L.A., Waggoner A.S., and Taylor D.L. Five-parameter fluorescence imaging: Wound healing of living Swiss 3T3 cells. J. Cell Biol. 105 (1987) 1613-1622
-
(1987)
J. Cell Biol.
, vol.105
, pp. 1613-1622
-
-
DeBiasio, R.1
Bright, G.R.2
Ernst, L.A.3
Waggoner, A.S.4
Taylor, D.L.5
-
4
-
-
0032526988
-
Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation
-
Engel K., Kotlyarov A., and Gaestel M. Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. EMBO J. 17 (1998) 3363-3371
-
(1998)
EMBO J.
, vol.17
, pp. 3363-3371
-
-
Engel, K.1
Kotlyarov, A.2
Gaestel, M.3
-
5
-
-
0036165251
-
Pharmacological inhibitors of MAPK pathways
-
English J.M., and Cobb M.H. Pharmacological inhibitors of MAPK pathways. Trends Pharmacol. Sci. 23 (2002) 40-45
-
(2002)
Trends Pharmacol. Sci.
, vol.23
, pp. 40-45
-
-
English, J.M.1
Cobb, M.H.2
-
6
-
-
0035990893
-
Protein kinases as targets for anticancer agents: From inhibitors to useful drugs
-
Fabbro D., Ruetz S., Buchdunger E., Cowan-Jacob S.W., Fendrich G., Liebetanz J., Mestan J., O'Reilly T., Traxler P., Chaudhuri B., Fretz H., Zimmermann J., Meyer T., Caravatti G., Furet P., and Manley P.W. Protein kinases as targets for anticancer agents: From inhibitors to useful drugs. Pharmacol. Ther. 93 (2002) 79-98
-
(2002)
Pharmacol. Ther.
, vol.93
, pp. 79-98
-
-
Fabbro, D.1
Ruetz, S.2
Buchdunger, E.3
Cowan-Jacob, S.W.4
Fendrich, G.5
Liebetanz, J.6
Mestan, J.7
O'Reilly, T.8
Traxler, P.9
Chaudhuri, B.10
Fretz, H.11
Zimmermann, J.12
Meyer, T.13
Caravatti, G.14
Furet, P.15
Manley, P.W.16
-
7
-
-
0032910168
-
Organization and regulation of mitogen activated protein kinase signaling pathways
-
Garrington T.P., and Johnson G.L. Organization and regulation of mitogen activated protein kinase signaling pathways. Curr. Opin. Cell Biol. 11 (1999) 211-218
-
(1999)
Curr. Opin. Cell Biol.
, vol.11
, pp. 211-218
-
-
Garrington, T.P.1
Johnson, G.L.2
-
8
-
-
0001341562
-
High-content screening: A new approach to easing key bottlenecks in the drug discovery process
-
Giuliano K.A., DeBiasio R.L., Dunlay R.T., Gough A., Volosky J.M., Zock J., Pavlakis G.N., and Taylor D.L. High-content screening: A new approach to easing key bottlenecks in the drug discovery process. J. Biomol. Screen. 2 (1997) 249-259
-
(1997)
J. Biomol. Screen.
, vol.2
, pp. 249-259
-
-
Giuliano, K.A.1
DeBiasio, R.L.2
Dunlay, R.T.3
Gough, A.4
Volosky, J.M.5
Zock, J.6
Pavlakis, G.N.7
Taylor, D.L.8
-
9
-
-
0032031530
-
Fluorescent-protein biosensors: New tools in drug discovery
-
Giuliano K.A., and Taylor D.L. Fluorescent-protein biosensors: New tools in drug discovery. TIBTech. 16 (1998) 135-140
-
(1998)
TIBTech.
, vol.16
, pp. 135-140
-
-
Giuliano, K.A.1
Taylor, D.L.2
-
10
-
-
0037085583
-
Cellular platforms for HTS: Three case studies
-
Johnston P.A., and Johnston P.A. Cellular platforms for HTS: Three case studies. Drug Discov. Today 7 (2002) 353-363
-
(2002)
Drug Discov. Today
, vol.7
, pp. 353-363
-
-
Johnston, P.A.1
Johnston, P.A.2
-
11
-
-
0033145354
-
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis
-
Kotlyarov A., Neininger A., Schubert C., Eckert R., Birchmeier C., Volk H.D., and Gaestel M. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nature Cell Biol. 1 (1999) 94-97
-
(1999)
Nature Cell Biol.
, vol.1
, pp. 94-97
-
-
Kotlyarov, A.1
Neininger, A.2
Schubert, C.3
Eckert, R.4
Birchmeier, C.5
Volk, H.D.6
Gaestel, M.7
-
12
-
-
20144388437
-
Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN Cell 3000 analyzer
-
Lundholt B.K., Linde V., Loechel F., Pedersen H.C., Moller S., Praestegaard M., Mikkelsen I., Scudder K., Bjorn S.P., Heide M., Arkhammar P.O., Terry R., and Nielsen S.J. Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN Cell 3000 analyzer. J. Biomol. Screen. 10 (2005) 20-29
-
(2005)
J. Biomol. Screen.
, vol.10
, pp. 20-29
-
-
Lundholt, B.K.1
Linde, V.2
Loechel, F.3
Pedersen, H.C.4
Moller, S.5
Praestegaard, M.6
Mikkelsen, I.7
Scudder, K.8
Bjorn, S.P.9
Heide, M.10
Arkhammar, P.O.11
Terry, R.12
Nielsen, S.J.13
-
13
-
-
12344250982
-
Small-molecule screening and profiling by using automated microscopy
-
Mitchison T.J. Small-molecule screening and profiling by using automated microscopy. Chembiochem. 6 (2005) 33-39
-
(2005)
Chembiochem.
, vol.6
, pp. 33-39
-
-
Mitchison, T.J.1
-
14
-
-
0036479125
-
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
-
Neininger A., Kontoyiannis D., Kotlyarov A., Winzen R., Eckert R., Volk H.D., Holtmann H., Kollias G., and Gaestel M. MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J. Biol. Chem. 277 (2002) 3065-3068
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3065-3068
-
-
Neininger, A.1
Kontoyiannis, D.2
Kotlyarov, A.3
Winzen, R.4
Eckert, R.5
Volk, H.D.6
Holtmann, H.7
Kollias, G.8
Gaestel, M.9
-
15
-
-
0034859534
-
FRET-based detection of different conformations of MK2
-
Neininger A., Thielemann H., and Gaestel M. FRET-based detection of different conformations of MK2. EMBO Rep. 2 (2001) 703-708
-
(2001)
EMBO Rep.
, vol.2
, pp. 703-708
-
-
Neininger, A.1
Thielemann, H.2
Gaestel, M.3
-
16
-
-
1642323740
-
Protein kinase inhibitors: Insights into drug design and structure
-
Noble M.E.M., Endicott J.A., and Johnson L.N. Protein kinase inhibitors: Insights into drug design and structure. Science 303 (2004) 1800-1805
-
(2004)
Science
, vol.303
, pp. 1800-1805
-
-
Noble, M.E.M.1
Endicott, J.A.2
Johnson, L.N.3
-
17
-
-
0033965158
-
The p38 signal transduction pathway, activation and function
-
Ono K., and Han J. The p38 signal transduction pathway, activation and function. Cell. Signal. 12 (2000) 1-13
-
(2000)
Cell. Signal.
, vol.12
, pp. 1-13
-
-
Ono, K.1
Han, J.2
-
18
-
-
0041968413
-
Automated screening of neurite outgrowth
-
Ramm P., Alexandrov Y., Cholewinski A., Cybuch Y., Nadon R., and Soltys B.J. Automated screening of neurite outgrowth. J. Biomol. Screen. 8 (2003) 7-18
-
(2003)
J. Biomol. Screen.
, vol.8
, pp. 7-18
-
-
Ramm, P.1
Alexandrov, Y.2
Cholewinski, A.3
Cybuch, Y.4
Nadon, R.5
Soltys, B.J.6
-
19
-
-
0037019275
-
Pyrazole urea-based inhibitors of p38 MAP kinase: From lead compound to clinical candidate
-
Regan J., Breitfelder S., Cirillo P., Gilmore T., Graham A.G., Hickey E., Klaus B., Madwed J., Moriak M., Moss N., Pargellis C., Pav S., Proto A., Swinamer A., Tong L., and Torcellini C. Pyrazole urea-based inhibitors of p38 MAP kinase: From lead compound to clinical candidate. J. Med. Chem. 45 (2002) 2994-3008
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2994-3008
-
-
Regan, J.1
Breitfelder, S.2
Cirillo, P.3
Gilmore, T.4
Graham, A.G.5
Hickey, E.6
Klaus, B.7
Madwed, J.8
Moriak, M.9
Moss, N.10
Pargellis, C.11
Pav, S.12
Proto, A.13
Swinamer, A.14
Tong, L.15
Torcellini, C.16
-
20
-
-
0034883501
-
Using green fluorescent protein to study intracellular signaling
-
Tavare J.M., Fletcher L.M., and Welsh G.I. Using green fluorescent protein to study intracellular signaling. J. Endocrinol. 170 (2001) 297-306
-
(2001)
J. Endocrinol.
, vol.170
, pp. 297-306
-
-
Tavare, J.M.1
Fletcher, L.M.2
Welsh, G.I.3
-
21
-
-
15744405770
-
Stealth sensors: Real-time monitoring of the cell cycle
-
Thomas N., and Goodyer D. Stealth sensors: Real-time monitoring of the cell cycle. Targets 2 (2003) 26-33
-
(2003)
Targets
, vol.2
, pp. 26-33
-
-
Thomas, N.1
Goodyer, D.2
-
22
-
-
33750815755
-
Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 MAPK inhibitors on the ArrayScan 3.1 imaging platform
-
(this volume)
-
Trask Jr. O.J., Baker A., Williams R.G., Kickischer D., Kandasamy R., Laethem C., Johnston P.A., and Johnston P.A. Assay development and case history of a 32K-biased library high-content MK2-EGFP translocation screen to identify p38 MAPK inhibitors on the ArrayScan 3.1 imaging platform. Methods Enzymol. 414 (2006) (this volume)
-
(2006)
Methods Enzymol.
, vol.414
-
-
Trask Jr., O.J.1
Baker, A.2
Williams, R.G.3
Kickischer, D.4
Kandasamy, R.5
Laethem, C.6
Johnston, P.A.7
Johnston, P.A.8
-
23
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
Zhang J.H., Chung T.D., and Oldenburg K.R. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4 (1999) 67-73
-
(1999)
J. Biomol. Screen.
, vol.4
, pp. 67-73
-
-
Zhang, J.H.1
Chung, T.D.2
Oldenburg, K.R.3
-
24
-
-
0028883299
-
Characterization of an autoinhibitory domain in human mitogen-activated protein kinase-activated protein kinase 2
-
Zu Y.L., Ai Y., and Huang C.K. Characterization of an autoinhibitory domain in human mitogen-activated protein kinase-activated protein kinase 2. J. Biol. Chem. 270 (1995) 202-206
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 202-206
-
-
Zu, Y.L.1
Ai, Y.2
Huang, C.K.3
|