Inhibition of GABA(A) receptor function by tyrosine kinase inhibitors and their inactive analogues

Molecular and Cellular Neurosciences

Volumn 12, Issue 4-5, 1998, Pages 300-310

  Dunne, Emma L ^a   Moss, Stephen J ^b   Smart, Trevor G ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; 4 AMINOBUTYRIC ACID; ENZYME INHIBITOR; GENISTEIN; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; TYRPHOSTIN; TYRPHOSTIN 25;

ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; NERVE CELL MEMBRANE POTENTIAL; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; AMINO ACID SUBSTITUTION; ANIMAL; CELL CULTURE; CELL LINE; CELL MEMBRANE POTENTIAL; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; KINETICS; OOCYTE; PHYSIOLOGY; POINT MUTATION; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CELLS, CULTURED; ENZYME INHIBITORS; GAMMA-AMINOBUTYRIC ACID; GENISTEIN; HUMANS; KINETICS; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POINT MUTATION; PROTEIN-TYROSINE KINASES; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; TRANSFECTION; TYRPHOSTINS; XENOPUS LAEVIS;

EID: 0031593392     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1998.0717     Document Type: Article

References (34)

1. Akiyama T., Ogawara H. Use and specificity of genistein as inhibitor of protein-tyrosine kinases. Meth. Enzymol. 201:1991;362-370.
2. Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S-I., Itoh N., Shibuya M., Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262:1987;5592-5595.
3. A. Neuroscience. 84:1998;529-535.
4. Chiang C-E., Chen S-A., Chang M-S., Lin C-I., Luk H-N. Genistein directly induces cardiac CFTR chloride current by a tyrosine kinase-independent and protein kinase A-independent pathway in guinea pig ventricular myocytes. Biochem. Biophys. Res. Commun. 235:1997;74-78.
5. Connolly C. N., Krishek B. J., McDonald B. J., Smart T. G., Moss S. J. Assembly and cell surface expression of heteromeric and homomeric γ-aminobutyric acid type A receptors. J. Biol. Chem. 271:1996;89-96.
6. A. Nature. 385:1997;820-823.
7. A. Br. J. Pharmacol. 123:1998;198P.
8. -. Am. J. Physiol. 273:1997;C747-C753.
9. Gazit A., Yaish P., Gilon C., Levitzki A. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J. Med. Chem. 32:1989;2344-2352.
10. Heim R., Prasher D. C., Tsien R. Y. Wavelength mutations and post-translational autoxidation of green fluorescent protein. Proc. Natl. Acad. Sci. USA. 91:1994;12501-12504.
11. Higahsi K., Ogawara H. Effects of isoflavone compounds on the activation of phospholipase C. Chem., Pharm. Bull. 40:1992;157-160.
12. Huang J. M., Nasr M., Kim Y. H., Matthews H. R. Genistein inhibits protein histidine kinase. J. Biol. Chem. 267:1992;15511-15515.
13. Hwang T-C., Wang F., Yang I. C-H., Reenstra W. W. Genistein potentiates wild-type and ΔF508-CFTR channel activity. Am. J. Physiol. 273:1997;C988-C998.
14. A. Brain Res. 775:1997;127-133.
15. A. Neuron. 12:1994;1081-1095.
16. A. Nature Neurosci. 1:1998;23-28.
17. A. Science. 257:1992;661-665.
18. A. Nature. 377:1995;344-348.
19. Moss S. J., Smart T. G. Modulation of amino acid-gated ion channels by protein phosphorylation. Int. Rev. of Neurobiol. 39:1996;1-52.
20. Okajima F., Akbar M., Majid M. A., Sho K., Tomura H., Kondo Y. Genistein, an inhibitor of protein-tyrosine kinases, is also a competitive antagonist for P1 purinergic (adenosine) receptor in FRTL-5 thyroid cells. Biochem. Biophys. Res. Commun. 203:1994;1488-1495.
21. Otero A. D., Sweitzer N. M. Benoquinoid tyrosine kinase inhibitors are potent blockers of cardiac muscarinic receptor function. Mol. Pharmacol. 44:1993;595-604.
22. A. Synapse. 21:1995;189-274.
23. Reenstra W. W., Yurko-Mauro K., Dam A., Raman S., Shorten S. CFTR chloride channel activation by genistein: The role of serine/threonine protein phosphatases. Am. J. Physiol. 271:1995;C650-C657.
24. Riordan J. R. The cystic fibrosis transmembrane regulator. Annu. Rev. Physiol. 55:1993;609-630.
25. Smart T. G. Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation. Curr. Opin. Neurobiol. 7:1997;358-367.
26. A. Amino Acid Neurotransmission. 1998;Portland Press, London. p. 37-63.
27. Smart T. G., Krishek B. J. Xenopus. Boulton A., Baker G., Walz W. Neuromethods, Vol 26: Patch Clamp Application and Protocols. 1995;259-305 Humana Press, Clifton.
28. +. Circ. Res. 76:1995;310-316.
29. A. Mol. Brain Res. 31:1995;165-172.
30. A. J. Neurosci. 17:1997;5062-5069.
31. Wang F., Zeltwanger S., Yang I. C-H., Nairn A. C., Hwang T-C. Actions of Genistein on cystic fibrosis transmembrane conductance regulator channel gating. Evidence for two binding sites with opposite effects. J. Gen. Physiol. 111:1998;477-490.
32. Weinrich F., Wood P. G., Riordan J. R., Nagel G. Direct action of Genistein on CFTR. Pflugers Arch. 434:1997;484-491.
33. Wijetunge S., Aalkjaer C., Schachter M., Hughes A. D. Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 189:1992;1620-1623.
34. A. Eur. J. Neurosci. 9:1997;2225-2235.