Dynamic Green Fluorescent Protein Sensors for High-Content Analysis of the Cell Cycle

Methods in Enzymology

Volumn 414, Issue , 2006, Pages 1-21

  Stubbs, Simon ^a   Thomas, Nick ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN D2; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE 7; CYCLIN E; DEMECOLCINE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; HISTONE DEACETYLASE; NOCODAZOLE; OLOMOUCINE; PACLITAXEL; PROPIDIUM IODIDE; PROTEIN MDM2; RETINOL BINDING PROTEIN; ROSCOVITINE; SMALL INTERFERING RNA;

AUTOMATION; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL DIVISION; CELLULAR DISTRIBUTION; CORRELATION ANALYSIS; DNA CONTENT; DNA REPAIR; DNA REPLICATION; DRUG TARGETING; ENDOREDUPLICATION; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENETIC SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; IMAGE ANALYSIS; NONHUMAN; PHASE TRANSITION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVIEW; SENSOR; STAINING;

MAMMALIA;

EID: 33750802773     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(06)14001-X     Document Type: Chapter

References (69)

1. Aleem E., Kiyokawa H., and Kaldis P. Cdc2-cyclin E complexes regulate the G1/S phase transition. Nature Cell Biol. 7 8 (2005) 831-836
2. Arendt T. Dysregulation of neuronal differentiation and cell cycle control in Alzheimer's disease. J. Neural Transm. Suppl. 62 (2002) 77-85
3. Arnaud L., Pines J., and Nigg E.A. GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes. Chromosoma 107 6-7 (1998) 424-429
4. Bicknell K.A., Surry E.L., and Brooks G. Targeting the cell cycle machinery for the treatment of cardiovascular disease. J. Pharm. Pharmacol. 55 5 (2003) 571-591
5. Blagden S., and de Bono J. Drugging cell cycle kinases in cancer therapy. Curr. Drug Targets 6 3 (2005) 325-335
6. Carnero A. Targeting the cell cycle for cancer therapy. Br. J. Cancer 87 (2002) 129-133
7. Clute P., and Pines J. Temporal and spatial control of cyclin B1 destruction in metaphase. Nature Cell Biol. 1 (1999) 82-87
8. Cobrinik D. Pocket proteins and cell cycle control. Oncogene 24 17 (2005) 2796-2809
9. Crain S.M., and Shen K.F. Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions. Trends Pharmacol. Sci. 19 9 (1998) 358-365
10. Denizot F., and Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Methods 89 2 (1986) 271-277
11. Dutcher J.P. Mammalian target of rapamycin (mTOR) inhibitors. Curr. Oncol. Rep. 6 2 (2004) 111-115
12. Fu M., Wang C., Li Z., Sakamaki T., and Pestell R.G. Cyclin D1: Normal and abnormal functions. Endocrinology 145 12 (2004) 5439-5447
13. Galati D., Bocchino M., Paiardini M., Cervasi B., Silvestri G., and Piedimonte G. Cell cycle dysregulation during HIV infection: Perspectives of a target based therapy. Curr. Drug Targets Immune Endocr. Metabol. Disord. 2 1 (2002) 53-61
14. Gillessen S., Groettup M., and Cerny T. The proteasome, a new target for cancer therapy. Onkologie 25 6 (2002) 534-539
15. Graves R., Davies R., Brophy G., O'Beirne G., and Cook N. Noninvasive, real-time method for the examination of thymidine uptake events-application of the method to V-79 cell synchrony studies. Anal. Biochem. 248 2 (1997) 251-257
16. Gu J., Xia X., Yan P., Liu H., Podust V.N., Reynolds A.B., and Fanning E. Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci. Mol. Biol. Cell 15 7 (2004) 3320-3332
17. Hadfield J.A., Ducki S., Hirst N., and McGown A.T. Tubulin and microtubules as targets for anticancer drugs. Prog. Cell Cycle Res. 5 (2003) 309-325
18. Hagting A., Jackman M., Simpson K., and Pines J. Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal. Curr. Biol. 9 13 (1999) 680-689
19. Hamel E., and Covell D.G. Antimitotic peptides and depsipeptides. Curr. Med. Chem. Anti-Cancer Agents 2 1 (2002) 19-53
20. Horie T., Sakaida I., Yokoya F., Nakajo M., Sonaka I., and Okita K. L-cysteine administration prevents liver fibrosis by suppressing hepatic stellate cell proliferation and activation. Biochem. Biophys. Res. Commun. 305 1 (2003) 94-100
21. Huang J., and Raff J.W. The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells. EMBO J. 18 8 (1999) 2184-2195
22. Humbert C., Giroud F., and Brugal G. Detection of S cells and evaluation of DNA denaturation protocols by image cytometry of fluorescent BrdUrd labelling. Cytometry 11 4 (1990) 481-489
23. Hwang A., Maity A., McKenna W.G., and Muschel R.J. Cell cycle-dependent regulation of the cyclin B1 promoter. J. Biol. Chem. 270 47 (1995) 28419-28424
24. Jagtap P., and Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nature Rev. Drug Discov. 4 5 (2005) 421-440
25. Kanda T., Sullivan K.F., and Wahl G.M. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr. Biol. 8 7 (1998) 377-385
26. Kawabe T. G2 checkpoint abrogators as anticancer drugs. Mol. Cancer Ther. 3 4 (2004) 513-519
27. Kendall J.M., Ismail R., and Thomas N. Adenoviral sensors for high-content cellular analysis. Methods Enzymol. 414 (2006) (this volume)
28. Kohn K.W. Molecular interaction map of the mammalian cell cycle control and DNA repair systems. Mol. Biol. Cell 10 8 (1999) 2703-2734
29. Lei M. The MCM complex: Its role in DNA replication and implications for cancer therapy. Curr. Cancer Drug Targets 5 5 (2005) 365-380
30. Li Q., and Zhu G.D. Targeting serine/threonine protein kinase B/Akt and cell-cycle checkpoint kinases for treating cancer. Curr. Top. Med. Chem. 2 9 (2002) 939-971
31. Liu X., and Erikson R.L. Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc. Natl. Acad. Sci. USA 100 10 (2003) 5789-5794
32. Lundholt B.K., Linde V., Loechel F., Pedersen H.C., Moller S., Praestegaard M., Mikkelsen I., Scudder K., Bjorn S.P., Heide M., Arkhammar P.O., Terry R., and Nielsen S.J. Identification of Akt pathway inhibitors using redistribution screening on the FLIPR and the IN Cell 3000 Analyzer. J. Biomol. Screen. 10 1 (2005) 20-29
33. Majoul I., Schmidt T., Pomasanova M., Boutkevich E., Kozlov Y., and Soling H.D. Differential expression of receptors for Shiga and Cholera toxin is regulated by the cell cycle. J. Cell Sci. 115 Pt. 4 (2002) 817-826
34. Miljan E.A., Meuillet E.J., Mania-Farnell B., George D., Yamamoto H., Simon H.G., and Bremer E.G. Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides. J. Biol. Chem. 277 12 (2002) 10108-10113
35. Mortlock A., Keen N.J., Jung F.H., Heron N.M., Foote K.M., Wilkinson R., and Green S. Progress in the development of selective inhibitors of Aurora kinases. Curr. Top Med. Chem. 5 2 (2005) 199-213
36. Nurse P. The incredible life and times of biological cells. Science 289 (2000) 1711-1716
37. Nurse P. A long twentieth century of the cell cycle and beyond. Cell 100 (2000) 71-78
38. O'Hare M., Wang F., and Park D.S. Cyclin-dependent kinases as potential targets to improve stroke outcome. Pharmacol. Ther. 93 2-3 (2002) 135-143
39. Owa T., Yoshino H., Yoshimatsu K., and Nagasu T. Cell cycle regulation in the G1 phase: A promising target for the development of new chemotherapeutic anticancer agents. Curr. Med. Chem. 12 (2001) 1487-1503
40. Pines J. Four-dimensional control of the cell cycle. Nature Cell Biol. 1 3 (1999) 73-79
41. Pommier Y., Redon C., Rao V.A., Seiler J.A., Sordet O., Takemura H., Antony S., Meng L., Liao Z., Kohlhagen G., Zhang H., and Kohn K.W. Repair of and checkpoint response to topoisomerase I-mediated DNA damage. Mutat. Res. 532 1-2 (2003) 173-203
42. Raff J.W., Jeffers K., and Huang J.Y. The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time. J. Cell. Biol. 157 7 (2002) 1139-1149
43. Ramm P., and Thomas N. Image-based screening of signal transduction assays. Sci. STKE 177 (2003) PE14
44. Reits E.A., Benham A.M., Plougastel B., Neefjes J., and Trowsdale J. Dynamics of proteasome distribution in living cells. EMBO J. 16 20 (1997) 6087-6094
45. Rusnati M., Urbinati C., Tanghetti E., Dell'Era P., Lortat-Jacob H., and Presta M.. Cell membrane GM1 ganglioside is a functional coreceptor for fibroblast growth factor 2. Proc. Natl. Acad. Sci. USA 99 7 (2002) 4367-4372
46. Sampath D., and Plunkett W. Design of new anticancer therapies targeting cell cycle checkpoint pathways. Curr. Opin. Oncol. 13 (2001) 484-490
47. Seville L.L., Shah N., Westwell A.D., and Chan W.C. Modulation of pRB/E2F functions in the regulation of cell cycle and in cancer. Curr. Cancer Drug Targets 5 3 (2005) 159-170
48. Sharma S., Doherty K.M., and Brosh Jr. R.M. DNA helicases as targets for anti-cancer drugs. Curr. Med. Chem. Anti-Cancer Agents 5 3 (2005) 183-199
49. Sherr C.J., and Roberts J.M. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18 22 (2004) 2699-2711
50. Smith P.J., Blunt N., Wiltshire M., Hoy T., Teesdale-Spittle P., Craven M.R., Watson J.V., Amos W.B., Errington R.J., and Patterson L.H. Characteristics of a novel deep red/infrared fluorescent cell-permeant DNA probe, DRAQ5, in intact human cells analyzed by flow cytometry, confocal and multiphoton microscopy. Cytometry 40 4 (2000) 280-291
51. Stark G.R., and Gudkov A.V. Forward genetics in mammalian cells: Functional approaches to gene discovery. Hum. Mol. Genet. 8 10 (1999) 1925-1938
52. Stewart Z.A., Westfall M.D., and Pietenpol J.A. Cell-cycle dysregulation and anticancer therapy. Trends Pharmacol. Sci. 24 3 (2003) 139-145
53. Takizawa C.G., and Morgan D.O. Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr. Opin. Cell Biol. 12 6 (2000) 658-665
54. Taneja P., Gu J., Peng R., Carrick R., Uchiumi F., Ott R.D., Gustafson E., Podust V.N., and Fanning E. A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication. J. Biol. Chem. 277 43 (2002) 40853-40861
55. Tatebe H., Goshima G., Takeda K., Nakagawa T., Kinoshita K., and Yanagida M. Fission yeast living mitosis visualized by GFP-tagged gene products. Micron 32 1 (2001) 67-74
56. Thomas N. Lighting the circle of life: Fluorescent sensors for covert surveillance of the cell cycle. Cell Cycle 2 6 (2003) 545-549
57. Thomas N., and Goodyer I. Stealth sensors: Real time monitoring of the cell cycle. Drug Disc. Today Targets 2 1 (2003) 26-33
58. Thomas N., Kenrick M., Giesler T., Kiser G., Tinkler H., and Stubbs S. Characterization and gene expression profiling of a stable cell line expressing a cell cycle GFP sensor. Cell Cycle 4 1 (2005) 191-195
59. Tsien R.Y. The green fluorescent protein. Annu. Rev. Biochem. 67 (1998) 509-544
60. Valdes-Gonzalez T., Inagawa J., and Ido T. Neuropeptides interact with glycolipid receptors: A surface plasmon resonance study. Peptides 22 7 (2001) 1099-1106
61. Vermeulen K., Van Bockstaele D.R., and Berneman Z.N. The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 36 3 (2003) 131-149
62. Weingartner M., Binarova P., Drykova D., Schweighofer A., David J.P., Heberle-Bors E., Doonan J., and Bogre L. Dynamic recruitment of Cdc2 to specific microtubule structures during mitosis. Plant Cell 13 8 (2001) 1929-1943
63. Willingham A.T., Deveraux Q.L., Hampton G.M., and Aza-Blanc P. RNAi and HTS: Exploring cancer by systematic loss-of-function. Oncogene 23 51 (2004) 8392-8400
64. Wong C.F., Guminski A., Saunders N.A., and Burgess A.J. Exploiting novel cell cycle targets in the development of anticancer agents. Curr. Cancer Drug Targets 5 2 (2005) 85-102
65. Yuan J., Eckerdt F., Bereiter-Hahn J., Kurunci-Csacsko E., Kaufmann M., and Strebhardt K. Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. Oncogene 21 54 (2002) 8282-8292
66. Yu Z., Lin J., Xiao Y., Han J., Zhang X., Jia H., Tang Y., and Li Y. Induction of cell-cycle arrest by all-trans retinoic acid in mouse embryonic palatal mesenchymal (MEPM) cells. Toxicol. Sci. 83 2 (2005) 349-354
67. Zeng Y., Hirano K., Hirano M., Nishimura J., and Kanaide H. Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor. Biochem. Biophys. Res. Commun. 274 1 (2000) 37-42
68. Zhang D., Vuocolo S., Masciullo V., Sava T., Giordano A., Soprano D.R., and Soprano K.J. Cell cycle genes as targets of retinoid induced ovarian tumor cell growth suppression. Oncogene 20 55 (2001) 7935-7944
69. Zhang J., Campbell R.E., Ting A.Y., and Tsien R.Y. Creating new fluorescent probes for cell biology. Nature Rev. Mol. Cell. Biol. 3 12 (2002) 906-918