Ligand-dependent and -independent degradation of the human aryl hydrocarbon receptor (hAHR) in cell culture models

Chemico-Biological Interactions

Volumn 164, Issue 1-2, 2006, Pages 49-59

  Pollenz, Richard S ^a   Buggy, Christine ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

26S proteasome; Human aryl hydrocarbon receptor; Human cell culture; Protein degradation; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; GELDANAMYCIN; LIGAND; PROTEASOME INHIBITOR;

ADENOSQUAMOUS CARCINOMA; ARTICLE; BINDING KINETICS; BRAIN CANCER; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DEGRADATION KINETICS; DRUG EXPOSURE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN VERSUS ANIMAL COMPARISON; KIDNEY CARCINOMA; LIGAND BINDING; LUNG FIBROBLAST; LUNG PARENCHYMA; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

BENZOQUINONES; BIODEGRADATION, ENVIRONMENTAL; CELL CULTURE TECHNIQUES; CELL LINE; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; HUMANS; LACTAMS, MACROCYCLIC; LEUPEPTINS; LIGANDS; MODELS, BIOLOGICAL; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; TETRACHLORODIBENZODIOXIN; TIME FACTORS;

DANIO RERIO; RODENTIA;

EID: 33750744456     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2006.08.014     Document Type: Article

References (45)

1. Petrulis J.R., Kusnadi A., Ramados P., Hollingshead B., and Perdew G.H. The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activity. J. Biol. Chem. 278 (2003) 2677-2685
2. Petrulis J.R., and Perdew G.H. The role of chaperone proteins in the aryl hydrocarbon receptor core complex. Chem. Biol. Interact. 141 (2002) 25-40
3. Heid S.E., Pollenz R.S., and Swanson H.I. Role of heat shock protein 90 dissociation in mediating agonist-induced activation of the aryl hydrocarbon receptor. Mol. Pharm. 57 (2000) 82-92
4. Lees M.J., and Whitelaw M.L. Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt. Mol. Cell. Biol. 19 (1999) 5811-5822
5. Swanson H.I. DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation. Chem. Biol. Interact. 141 (2002) 63-76
6. Pollenz R.S. Mechanism of Ah receptor down regulation (degradation) and its impact on AHR-mediated gene regulation. Chem. Biol. Interact. 141 (2002) 41-62
7. Song Z., and Pollenz R.S. Ligand dependent and independent modulation of AH receptor localization, degradation, and gene regulation. Mol. Pharm. 62 (2002) 806-816
8. Davarinos N., and Pollenz R.S. Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytosplasmic proteasome following nuclear export. J. Biol. Chem. 274 (1999) 28708-28715
9. Pollenz R.S., and Barbour E.R. Analysis of the complex relationship between nuclear export and Ah receptor-mediated gene regulation. Mol. Cell. Biol. 20 (2000) 6094-6105
10. Song Z., and Pollenz R.S. Functional Analysis of murine aryl hydrocarbon (AH) receptors defective in nuclear import: impact of receptor degradation and gene activation. Mol. Pharm. 63 (2003) 597-606
11. Ma Q., and Whitlock Jr. J.P. The AHR modulates the Hepa-1c1c7 cell cycle and differentiated state independently of dioxin. Mol. Cell. Biol. 16 (1996) 2144-2150
12. Fernandez-Salguero P., Pineau T., Hilbert D.M., McPhail T., Lee S.S., Kimura S., Nebert D.W., Rudikoff S., Ward J.M., and Gonzalez F.J. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268 (1995) 722-726
13. Hushka L.J., Williams J.S., and Greenlee W.F. Characterization of 2,3,7,8-tetrachlorodibenzofuran-dependent suppression and AH receptor pathway gene expression in the developing mouse mammary gland. Toxicol. Appl. Pharmacol. 152 (1998) 120-200
14. Peters J.M., Narotsky M.G., Elizondo G., Fernandez-Salguero P., Gonzalez F.J., and Abbott B.D. Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice. Toxicol. Sci. 47 (1999) 86-92
15. Schmidt J.V., Su G.H., Reddy J.K., Simon M.C., and Bradfield C.A. Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 6731-6736
16. Abbott B.D., Schmid D., Pitt J.E., Buckalew A.R., Wood C.R., Held G.A., and Diliberto J.J. Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. Toxicol. Appl. Pharmacol. 155 (1999) 62-70
17. Heimler I., Trewin A.L., Chaffin C.L., Rawlins R.G., and Hutz R.J. Modulation of ovarian follicle maturation and effects on apoptotic cell death in Holtzman rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero and lactationally. Reprod. Toxicol. 12 (1998) 69-73
18. Wolf C.J., Ostby J.S., and Gray L.E. Gestantional exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) severely alters reproductive function of female hamster offspring. Toxicol. Sci. 51 (1999) 259-264
19. Benedict J.C., Lin T.M., Loeffler I.K., Peterson R.E., and Flaws J.A. Physiological role of the aryl hydrocarbon receptor in mouse ovary development. Toxicol. Sci. 56 (2000) 382-388
20. Haupt Y., Maya R., Kazaz A., and Oren M. Mdm2 promotes the rapid degradation of p53. Nature 387 (1997) 266-296
21. Pugh C.W., and Ratcliffe P.J. The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. Semin. Cancer Biol. 13 (2003) 83-89
22. Pollenz R.S. The aryl hydrocarbon receptor but not Arnt protein is rapidly depleted in hepatic and non-hepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol. Pharm. 49 (1996) 391-398
23. Pollenz R.S., and Dougherty E.J. Redefining the role of XAP2 and CHIP in the degradation of endogenous AHR in cell culture models. J. Biol. Chem. 280 (2005) 33346-33356
24. Wang F., Hovick D., Pollenz R.S., and Safe S. Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes. Nucl. Acids Res. 26 (1998) 3044-3052
25. Ramadoss P., Petrulis J.R., Hollingshead B.D., Kusnadi A., and Perdew G.H. Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes. Biochemistry 43 (2004) 700-709
26. Manchester D.K., Gordon S.K., Golas C.L., Roberts E.A., and Okey A.B. Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene. Cancer Res. 47 (1987) 4861-4868
27. Harper P.A., Golas C.L., and Okey A.B. Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line. Cancer Res. 48 (1988) 2388-2395
28. Poland A., and Glover E. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol. Pharmacol. 38 (1990) 306-312
29. Poland A., Palen D., and Glover E. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol. Pharmacol. 46 (1994) 915-921
30. Hestermann E., and Brown M. Agonist and chemopreventive ligands induce differential transcriptional cofactor recruitment by the aryl hydrocarbon receptor. Mol. Cell. Biol. 23 (2003) 7920-7925
31. Wang S., Ge K., Roeder R.G., and Hankinson O. O Role of mediator in transcriptional activation by the aryl hydrocarbon receptor. J. Biol. Chem. 279 (2004) 13593-13600
32. Holmes J.L., and Pollenz R.S. Determination of aryl hydrocarbon receptor nuclear translocator protein concentration and subcellular localization in hepatic and nonhepatic cell culture lines: development of quantitative western blotting protocols for calculation of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein in total cell lysates. Mol. Pharmacol. 52 (1997) 202-211
33. Pollenz R.S., Sullivan H.L., Holmes J., Necela B., and Peterson R.E. Isolation and characterization of cDNAs from rainbow trout (Oncorhynchus mykiss) that encode two novel basic-helix-loop-helix/PAS proteins with distinct functions in the presence of the aryl hydrocarbon receptor. J. Biol. Chem. 271 (1996) 30886-30896
34. Necela B., and Pollenz R.S. Functional analysis of activation and represssion domains with the rainbow trout ARNT protein. Biochem. Pharmacol. 57 (1999) 1177-1190
35. Pollenz R.S., Sattler C.A., and Poland A. The aryl hydrocrabon receptor and aryl hydrocrabon receptor nuclear translocator protein show distinct subcellular localization in Hepa 1c1c7 cell by immunofluorescence microscopy. Mol. Pharm. 45 (1994) 428-438
36. b-1 receptor. Biochem. Pharmacol. 70 (2005) 1623-1633
37. Wentworth J.N., Buzzeo R., and Pollenz R.S. Functional characterization of aryl hydrocarbon receptor localization and degradation zebrafish. Biochem. Pharm. 67 (2004) 1363-1372
38. Giannone J.V., Okey A.B., and Harper P.A. Charcaterization of polyclonal antibodies to the aromatic hydrocarbon receptor. Can. J. Physiol. Pharmacol. 73 (1995) 7-17
39. Wormke M., Stoner M., Saville B., and Safe S. The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes. FEBS Lett. 478 (2000) 109-112
40. Ma Q., and Baldwin K.T. 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway. Role of the transcription activation and DNA binding of AhR. J. Biol. Chem. 275 (2000) 8432-8438
41. Robert B.J., and Whitelaw M.L. Degradation of the basic helix-loop-helix/Per-ARNT-Sim homology domain dioxin receptor via the ubiquitin/proteasome pathway. J. Biol. Chem. 274 (1999) 36351-36356
42. Grenert J.P., Sullivan W.P., and Fadden P. The amino terminal domain of heat shock protein 90 (hsp90) that bind geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. J. Biol. Chem. 272 (1997) 23843-23850
43. Whitesell L.L., Minmaugh E.G., Costa B.D., Meyers C.E., and Neckers L.M. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by bezoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 8324-8328
44. Schulte T.W., Blagosklonny M.V., Ingui C., and Neckers L.M. Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association. J. Biol. Chem. 261 (1995) 24585-24588
45. Chen H.S., Singh S.S., and Perdew G.H. The Ah receptor is a sensitive target of geldanamycin-induced protein turnover. Arch. Biochem. Biophys. 348 (1997) 190-198