Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) severely alters reproductive function of female hamster offspring

Toxicological Sciences

Volumn 51, Issue 2, 1999, Pages 259-264

  Wolf, C J ^a   Ostby, J S ^a   Gray Jr , L E ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Dioxin; Endocrine disruption; Fertility; Hamster; Hypospadias; Transgenerational effects; Vaginal estrous; Viability

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EPIDIDYMIS; ESTRUS CYCLE; FEMALE; FERTILITY; HAMSTER; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; MALE; NEWBORN; NONHUMAN; ORGAN WEIGHT; PRENATAL EXPOSURE; RAT; REPRODUCTIVE TOXICITY; SEX DIFFERENTIATION; SEXUAL MATURATION; SPERMATOZOON COUNT; UROGENITAL TRACT MALFORMATION;

ANIMALS; ANIMALS, NEWBORN; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO IMPLANTATION; ESTRUS; FEMALE; FERTILITY; GROWTH; LITTER SIZE; MALE; MESOCRICETUS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; REPRODUCTION; SEXUAL BEHAVIOR, ANIMAL; SEXUAL MATURATION; TERATOGENS; TETRACHLORODIBENZODIOXIN; VAGINA;

ANIMALIA; CRICETINAE; RODENTIA; ZEA MAYS;

EID: 0032728307     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/51.2.259     Document Type: Article

References (19)

1. Bjerke, D. L., Brown, R. J., MacLusky, N. J., Hochberg, R. B., and Peterson, R. E. (1994). Partial demasculinization and feminization of sex behavior in male rats by in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin is not associated with alterations in estrogen-receptor binding or volumes of sexually differentiated brain nuclei. Toxicol. Appl. Pharmacol. 127, 258-267.
2. Bjerke, D. L., and Peterson, R. E. (1994). Reproductive toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male rats: Different effects of in utero versus lactational exposure. Toxicol. Appl. Pharmacol. 127, 241-249.
3. Flaws, J. A., Sommer, R. J., Silbergeld, E. K., Peterson, R. E., and Hirshfield, A. N. (1997). In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces genital dysmorphogenesis in the female rat. Tox. Appl. Pharmacol. 147, 351-362.
4. Gray, L. E., Jr., Kelce, W. R., Monosson, E., Ostby, J. S., and Birnbaum, L. S. (1995). Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicol. Appl. Pharmacol. 131, 108-118.
5. Gray, L. E., Jr., and Ostby, J. S. (1995). In utero 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive morphology and function in female rat offspring. Toxicol. Appl. Pharmacol. 133, 285-294.
6. Gray, L. E., Jr., Wolf, C., Mann, P., and Ostby, J. S. (1997). In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive development of female Long Evans Hooded rat offspring. Toxicol. Appl. Pharmacol. 146, 237-244.
7. Hoar, R. M., and Monie, I. W. (1981). Comparative development of specific organ systems. In Developmental Toxicology (C. Kimmel and J. Buelke-Sam, Eds.), pp. 13-33. Raven Press, New York.
8. Kent, G. C. (1968). Physiology of Reproduction in the Golden Hamster (R. A. Haufman, P. S., Robinson, and H. Magalhaes, Eds.), pp 119-138. Iowa State University Press, Ames, IA.
9. Mably, T. A., Bjerke, D. L., Moore, R. W., Gendron-Fitzpatrick, A., and Peterson, R. E. (1992a). In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin: 3. Effects on spermatogenesisand reproductive capability. Toxicol. Appl. Pharmacol. 114, 118-126.
10. Mably, T. A., Moore, R. W., Goy, R. W., and Peterson, R. E. (1992b). In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin: 2. Effects on sexual behavior and regulation of luteinizing hormone secretion in adulthood. Toxicol. Appl. Pharmacol. 114, 108-117.
11. Mably, T. A., Moore, R. W., and Peterson, R. E. (1992c). In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenxo-p-dioxin: 1. Effects on androgenic status. Toxicol. Appl. Pharmacol. 114, 97-107.
12. Mann, P. C. (1997). Selected lesions of dioxin in laboratory rodents. Toxicol. Pathol. 25, 72-79.
13. Murray, F. J., Smith, F. A., Nitschke, K. D., Humiston, C. G., Kociba, R. J., and Schwetz, B. A. (1979). Three-generation reproduction study of rats giver 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet. Toxicol. Appl. Pharmacol. 50, 241-252.
14. Olson, J. R., Holscher, M. A., and Neal, R. A. (1980). Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Golden Syrian hamster. Toxicol. Appl. Pharmacol. 55, 67-78.
15. Olson, J., McGarrigle, B., Tonucci D. A., Schecter, A., and Eichelberger, H., 1990. Developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat and hamster. Chemosphere 20, 1117-1123.
16. Rudiger, H. W., and Jahn, O. (1993). Teratogenic risk by chlorinated dioxins: Is it likely in man? Organohalogen Compounds 14, 5-7.
17. Vannier, B., and Raynaud, J. P. (1980). Long-term effects of prenatal oestrogen treatment on genital morphology and reproductive function in the rat. J. Reprod. Fertil. 59, 43-49.
18. Voherr, H., Messer, R. H., Voherr, U. F., Jordan, S. W., and Kornfeld, M. (1979). Teratogenesis and carcinogenesis in rat offspring after transplacental and transmammary exposure to diethylstilbestrol. Biochem. Pharmacol. 28, 1865-1877.
19. Whitsett, J. M., Gray, L. E., and Bediz, G. M. (1978). Differential influence of stereoisomers of estradiol on sexual behavior of female hamsters. J Compar. Physiol. Psychol. 92, 7-12