High epithelial and stromal genetic instability of chromosome 17 in ulcerative: Colitis-associated carcinogenesis

Cancer Research

Volumn 63, Issue 19, 2003, Pages 6158-6161

  Matsumoto, Naoko ^a   Yoshida, Tsutomu ^a   Okayasu, Isao ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA; TUMOR MARKER;

ADULT; ARTICLE; CHROMOSOME 17; CHROMOSOME MICRODISSECTION; CHRONIC DISEASE; COLON CARCINOGENESIS; COLON CARCINOMA; DYSPLASIA; EPITHELIUM CELL; GENETIC MARKER; HETEROZYGOSITY LOSS; HISTOLOGY; HUMAN; HUMAN TISSUE; LASER; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; STROMA; ULCERATIVE COLITIS;

ADULT; CARRIER PROTEINS; CHROMOSOMES, HUMAN, PAIR 17; COLITIS, ULCERATIVE; COLORECTAL NEOPLASMS; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENES, P53; GENOMIC INSTABILITY; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; STROMAL CELLS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0141885131     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Hom, Y. K., Young, P., Wiesen, J. F., Miettinen, P. J., Derynck, R., Werb, Z., and Cunha, G. R. Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma. Endocrinology, 139: 913-921, 1998.
2. Shekhar, M. P., Werdell, J., Santner, S. J., Pauley, R. J., and Tait, L. Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression. Cancer Res., 61: 1320-1326, 2001.
3. Moinfar, F., Man, Y. G., Arnould, L., Bratthauer, G. L., Ratschek, M., and Tavassoli, F. A. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res., 60: 2562-2566, 2000.
4. Matsumoto, N., Yoshida, T., Yamashita, K., Numata, Y., and Okayasu, I. Possible alternative carcinogenesis pathway featuring microsatellite instability in colorectal cancer stroma. Br. J. Cancer, 89: 707-712, 2003.
5. Yoshida, T., Mikami, T., Mitomi, H., and Okayasu, I. Diverse p53 alterations in ulcerative colitis-associated low-grade dysplasia: full-length gene sequencing in microdissected single crypts. J. Pathol., 199: 166-175, 2003.
6. Hussain, S. P., Amstad, P., Raja, K., Ambs, S., Nagashima, M., Bennett, W. P., Shields, P. G., Ham, A. J., Swenberg, J. A., Marrogi, A. J., and Harris, C. C. Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res., 60: 3333-3337, 2000.
7. Boland, C. R., Thibodcau, S. N., Hamilton, S. R., Sidransky, D., Eshleman, J. R., Burt, R. W., Meltzer, S. J., Rodriguez-Bigas, M. A., Fodde, R., Ranzani, G. N., and Srivastava, S. A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res., 58: 5248-5257, 1998.
8. Riddell, R. H., Goldman, H., Ransohoff, D. F., Appelman, H. D., Fenoglio, C. M., Haggitt, R. C., Ahren, C., Correa, P., Hamilton, S. R., Morson, B. C., et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum. Pathol., 14: 931-968, 1983.
9. Sawyer, E. J., Hanby, A. M., Ellis, P., Lakhani, S. R., Ellis, I. O., Boyle, S., and Tomlinson, I. P. Molecular analysis of phyllodes tumors reveals distinct changes in the epithelial and stromal components. Am. J. Pathol., 156: 1093-1098, 2000.
10. Kurose, K., Hoshaw-Woodard, S., Adeyinka, A., Lemeshow, S., Watson, P. H., and Eng, C. Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions. Hum. Mol. Genet., 10: 1907-1913, 2001.
11. Kurose, K., Zhou, X. P., Araki, T., Cannistra, S. A., Maher, E. R., and Eng, C. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas. Am. J. Pathol., 158: 2097-2106, 2001.
12. Brentnall, T. A., Crispin, D. A., Bronner, M. P., Cherian, S. P., Hueffed, M., Rabinovitch, P. S., Rubin, C. E., Haggitt, R. C., and Boland, C. R. Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res., 56: 1237-1240, 1996.
13. Park, W. S., Pham, T., Wang, C., Pack, S., Mueller, E., Mueller, J., Vortmeyer, A., Zhuang, Z., and Fogt, F. Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis. Int. J. Mol. Med., 2: 221-224, 1998.
14. Okada, F., Kawaguchi, T., Habelhah, H., Kobayashi, T., Tazawa, H., Takeichi, N., Kitagawa, T., and Hosokawa, M. Conversion of human colonic adenoma cells to adenocarcinoma cells through inflammation in nude mice. Lab. Investig., 80: 1617-16281 2000.
15. Young, J., Simms, L. A., Biden, K. G., Wynter, C., Whitehall, V., Karamatic, R., George, J., Goldblatt, J., Walpole, I., Robin, S. A., Borten, M. M., Stitz, R., Searle, J., McKeone, D., Fraser, L., Purdie, D. R., Podger, K., Price, R., Buttenshaw, R., Walsh, M. D., Barker, M., Leggett, B. A., and Jass, J. R. Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. Am. J. Pathol., 159: 2107-2116, 2001.
16. Duval, A., and Hamelin, R. Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability. Cancer Res., 62: 2447-2454, 2002.
17. Fleisher, A. S., Esteller, M., Harpaz, N., Leytin, A., Rashid, A., Xu, Y., Liang, J., Stine, O. C., Yin, J., Zou, T. T., Abraham, J. M., Kong, D., Wilson, K. T., James, S. P., Herman, J. G., and Meltzer, S. J. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res., 60: 4864-4868, 2000.
18. Cawkwell, L., Sutherland, F., Murgatroyd, H., Jarvis, P., Gray, S., Cross, D., Shepherd, N., Day, D., and Quirke, P. Defective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers. Gut, 46: 367-369, 2000.
19. Werness, B. A., Parvatiyar, P., Ramus, S. J., Whittemore, A. S., Garlinghouse-Jones, K., Oakley-Girvan, I., DiCioccio, R. A., Wiest, J., Tsukada, Y., Ponder, B. A., and Piver, M. S. Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53. J. Natl. Cancer Inst. (Bethesda), 92: 1088-1091, 2000.
20. Zhang, H., Somasundaram, K., Peng, Y., Tian, H., Bi, D., Weber, B. L., and El-Deiry, W. S. (eds.). BRCA1 Physically Associates with p53 and Stimulates its Transcriptional Activity, Vol. 16, pp. 1713-1721, 1998.