Immunohistochemical screening of mismatch repair genes hMLH1, hMSH2, and hMSH6 in dysplastic lesions of the colon

Applied Immunohistochemistry and Molecular Morphology

Volumn 10, Issue 1, 2002, Pages 57-61

  Fogt, Franz ^a   Zimmerman, Robert L ^a   Poremba, Christopher ^a   Noffsinger, Amy E ^a   Alsaigh, Nada ^a   Rueschoff, Joseph ^a  

^a PENN PRESBYTERIAN MEDICAL CENTER   (United States)

Author keywords

Adenoma; DALM; Microsatellite; Mismatch repair genes

Indexed keywords

PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

ADULT; AGED; ARTICLE; COLON ADENOMA; COLORECTAL CANCER; CONTROLLED STUDY; DYSPLASIA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULCERATIVE COLITIS;

ADULT; AGED; AGED, 80 AND OVER; BASE PAIR MISMATCH; CARRIER PROTEINS; CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; COLONIC NEOPLASMS; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS;

EID: 0036182333     PISSN: 10623345     EISSN: None     Source Type: Journal    
DOI: 10.1097/00022744-200203000-00010     Document Type: Article

References (12)

1. An update of HNPCC (Lynch syndrome)
2. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
3. Comparison of genetic alterations in colonic adenoma and ulcerative colitis-associated dysplasia and carcinoma
4. A germline hMSH2 alteration is unrelated to colonic microsatellite instability in patients with ulcerative colitis
5. Loss of heterozygosity of the von Hippel Lindau gene locus in polypoid dysplasia but not flat dysplasia in ulcerative colitis or sporadic adenomas
6. Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences
7. Significance and detection of dysplasia in chronic colitis
8. Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis?
9. Von Hippel-Lindau disease gene deletion detected in microdissected sporadic human colon carcinoma specimens
10. Immunohistochemical detection of mismatch repair gene proteins as a useful tool for the identification of colorectal carcinoma with the mutator phenotype
11. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1
12. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines