Molecular basis for the partition of the essential functions of thrombin among snake venom serine proteinases: The case of thrombin-like enzymes

Haemostasis

Volumn 31, Issue 3-6, 2001, Pages 247-256

  Maroun, R C ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

Molecular modeling; Molecular recognition; Snake venoms; Thrombin; Thrombin like serine proteinases

Indexed keywords

SERINE PROTEINASE; SNAKE VENOM; THROMBIN; GLYCOPROTEIN; PLASMINOGEN ACTIVATOR; TSV PA PROTEIN, TRIMERESURUS STEJNEGERI; TSV-PA PROTEIN, TRIMERESURUS STEJNEGERI;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPARATIVE STUDY; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN TERTIARY STRUCTURE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; MOLECULAR GENETICS; MOLECULAR MIMICRY; PHYSIOLOGY; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; GLYCOPROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PLASMINOGEN ACTIVATORS; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SERINE ENDOPEPTIDASES; SNAKE VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 0035743546     PISSN: 03010147     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Comparative modeling methods: Application to the family of the mammalian serine proteases
2. A player of many parts: The spotlight falls on thrombin's structure
3. Structural basis of substrate specificity in the serine proteases
4. Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold
5. Thrombin signalling and protease-activated receptors
6. Domains specifying thrombin-receptor interaction
7. Thrombin structure and function: Why thrombin is the primary target for antithrombotics
8. Crystal structure of the thrombin-hirudin complex: A novel mode of serine protease inhibition
9. Refined structure of the hirudin-thrombin complex
10. Natural protein proteinase inhibitors and their interaction with proteinases
11. Thrombin specificity
12. Thrombin inhibition by hirudin: How hirudin inhibits thrombin
13. X-ray crystal structures of human α-thrombin and of the human thrombin-hirudin complex
14. Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III
15. Crystal structure of the human alpha-thrombin-haemadin complex: An exosite II-binding inhibitor
16. Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin
17. Introduction: Serine peptidases and their clans
18. Snake venoms
19. Thrombin-like enzymes from snake venoms: An updated inventory
20. Insights into the three-dimensional structure of crotalase: Implications for biological activity and substrate specificity
21. Methods and algorithms for statistical analysis of protein sequences
22. The crystal structure of the novel snake venom plasminogen activator TSV-PA: A prototype structure for snake venom serine proteinases
23. Molecular markers of serine protease evolution
24. Functional mapping of the surface residues of human thrombin
25. Trimeresurus stejnegeri snake venom plasminogen activator. Site-directed mutagenesis and molecular modeling
26. The C-terminal sequence encodes function in serine proteases
27. An allosteric switch controls the pro-coagulant and anticoagulant activities of thrombin
28. Kallikrein-like activity of crotalase, a snake venom enzyme that clots fibrinogen
29. The contribution of residues 192 and 193 to the specificity of snake venom serine proteinases
30. Unexpected crucial role of residue 225 in serine proteases
31. Rational engineering of activity and specificity in a serine protease
32. Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases
33. A novel venombin B from Agkistrodon contortrix contortrix: Evidence for recognition properties in the surface around the primary specificity pocket different from thrombin
34. Crotalase, a fibrinogen-clotting snake venom enzyme: Primary structure and evidence for a fibrinogen recognition exosite different from thrombin
35. Structural features of a snake venom thrombin-like enzyme: Thrombin and trypsin on a single catalytic platform?
36. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures