Detection of parent-of-origin effects in nuclear families using haplotype analysis

Human Heredity

Volumn 62, Issue 2, 2006, Pages 64-76

  Becker, Tim ^a   Baur, Max P ^a   Knapp, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

FAMHAP; Haplotype association analysis; Imprinting; Nuclear families; Parent of origin effects

Indexed keywords

ARTICLE; DISEASE MODEL; FAMILY; GENETIC DISORDER; GENETICS; GENOME IMPRINTING; HAPLOTYPE; HUMAN; MONTE CARLO METHOD; NUCLEAR FAMILY; PARENT; POPULATION; STATISTICS;

COMPUTER SIMULATION; FEMALE; GENETIC DISEASES, INBORN; GENETIC MARKERS; GENOMIC IMPRINTING; HAPLOTYPES; HUMANS; MALE; MONTE CARLO METHOD; NUCLEAR FAMILY; PARENTS;

EID: 33750621366     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095942     Document Type: Article

References (24)

1. Becker T, Knapp M: Maximum-likelihood estimation of haplotype frequencies in nuclear families. Genet Epidemiol 2004a;27:21-32.
2. Becker T, Knapp M: A powerful strategy to account for multiple testing in the context of haplotype analysis. Am J Hum Genet 2004b;75:561-570.
3. Clayton D, Chapman J, Cooper J: Use of unphased multilocus genotype data in indirect association studies. Genet Epidemiol 2004;27:415-428.
4. Fingerlin TE, Boehnke M, Abecasis GR: Increasing the power and effciency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet 2004;74:432-443.
5. Ge Y, Dudoit S, Speed TP: Resampling-based multiple testing for microarray data analysis. Test 2003;12:1-77.
6. Gordon D, Heath SC, Ott J: True pedigree errors more frequent than apparent errors for single nucleotide polymorphisms. Hum Hered 1999;49:65-70.
7. Hawi Z, Segurado R, Conroy J, Sheehan K, Lowe N, Kirley A, Shields D, et al: Preferetial transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. Am J Hum Genet 2005;77:958-965.
8. Hoh J, Wille A, Ott J: Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Research 2001;11:2115-2119.
9. Jannot AS, Essioux L, Reese MG, Clerget-Darpoux F: Improved use of SNP information to detect the role of genes. Genet Epidemiol 2003;25:158-167.
10. Knapp M, Becker T: Family-based association analysis with tightly linked markers. Hum Hered 2003;56:2-9.
11. Martin ER, Kaplan NL, Weir BS: Tests for linkage and association in nuclear families. Am J Hum Genet 1997;61:439-448.
12. Mitchell AA, Cutler DJ, Chakravarti A: Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test. Am J Hum Genet 2003;72:598-610.
13. Morris R, Kaplan N: On the advantage of haplotype analysis in the presence of multiple disease susceptibility alleles. Genet Epidemiol 2002;23:221-233.
14. Nikaido I, Saito C, Mizuno Y, Meguro M, Bono H, Kadomura M, Kono T, et al: Discovery of imprinted transcripts in the mouse transcriptome using large-scale expression profiling. Genome Res 2003;13:1402-1409.
15. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-516.
16. Spielman RS, Ewens WJ: The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 1996;59:983-989.
17. Van Den Bogaert A, Schumacher J, Schulze TG, Otte AC, Ohlraun S, Kovalenko S, Becker T, Freudenberg J, et al: The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease. Am J Hum Genet 2003;73:1438-1443.
18. Wang N, Akey JM, Zhang K, Chakraborty R, Jin L: Distribution of recombination crossovers and the origin of haplotype blocks: the interpaly of population history, recombination, and mutation. Am J Hum Genet 2002;71:1227-1234.
19. Weinberg CR, Wilcox AJ, Lie RT: A Log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet 1998;62:969-978.
20. Weinberg CR: Methods for detection of parent-origin effects in genetic studies of case-parent triads. Am J Hum Genet 1999;65:229-235.
21. Weinberg CR, Umbach DM: A hybrid design for studying genetic influences on risk of diseases with onset early in life. Am J Hum Genet 2005;77:627-636.
22. Wilcox AJ, Weinberg CR, Lie RT: Distinguishing the effects of maternal and offspring genotypes through studies of case-parent triads. Am J Epidemiol 1998;148:893-901.
23. Westfall PH, Young SS: Resampling-Based Multiple Testing: Examples and Methods for p-Value Adjustment. John Wiley and Sons, New York, 1993.
24. Zhao H, Zhang S, Merikangas KR, Trixler M, Wildenauer DB, Sun F, Kidd KK: Transmission/disequilibrium tests using multiple tightly linked markers. Am J Hum Genet 2000;67:936-946.