Hepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factors

Hepatology

Volumn 44, Issue 4, 2006, Pages 967-975

  Werth, Max ^a   Gebhardt, Rolf ^a   Gaunitz, Frank ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GLUTAMATE AMMONIA LIGASE; NUCLEAR PROTEIN; STAT5 PROTEIN; T CELL FACTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RAT; SEQUENCE ANALYSIS; ANIMAL; BIOSYNTHESIS; ENHANCER REGION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; LIVER CELL; METABOLISM; REPORTER GENE; SPRAGUE DAWLEY RAT;

ANIMALS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GENES, REPORTER; GLUTAMATE-AMMONIA LIGASE; HEPATOCYTES; MALE; NUCLEAR PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SEQUENCE ANALYSIS; STAT5 TRANSCRIPTION FACTOR; TCF TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 33750607896     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21322     Document Type: Article

References (30)

1. Gebhardt R, Mecke D. Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture. EMBO J 1983;2:567-570.
2. Gaunitz F, Deichsel D, Heise K, Werth M, Anderegg U, Gebhardt R. An intronic silencer element is responsible for specific zonal expression of glutamine synthetase in the rat liver. HEPATOLOGY 2005;41:1225-1232.
3. Kruithof-de Julio M, Labruyere WT, Ruijter JM, Vermeulen JL, Stanulovic V, Stallen JM, et al. The RL-ET-14 cell line mediates expression of glutamine synthetase through the upstream enhancer/promoter region. J Hepatol 2005;43:126-131.
4. Sekine S, Lan BY, Bedolli M, Feng S, Hebrok M. Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. HEPATOLOGY 2006;43:817-825.
5. Loeppen S, Schneider D, Gaunitz F, Gebhardt R, Kurek R, Buchmann A, et al. Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. Cancer Res 2002;62:5685-5688.
6. Cadoret A, Ovejero C, Terris B, Souil E, Levy L, Lamers WH, et al. New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism. Oncogene 2002;21:8293-8301.
7. Fahrner J, Labruyere WT, Gaunitz C, Moorman AF, Gebhardt R, Lamers WH. Identification and functional characterization of regulatory elements of the glutamine synthetase gene from rat liver. Eur J Biochem 1993;213:1067-1073.
8. Gaunitz F, Weber S, Scheja L, Gebhardt R. Identification of a cis-acting element and a novel trans-acting factor of the glutamine synthetase gene in liver cells. Biochem Biophys Res Commun 2001;284:377-383.
9. Burger HJ, Gebhardt R, Mayer C, Mecke D. Different capacities for amino acid transport in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfusion. HEPATOLOGY 1989;9:22-28.
10. Coen DM. Chapter 15. The polymerase chain reaction. In: Ausubel FM, Brent R, Kingston R, Moore DD, Seidmann JG, Smith JA, et al., eds. Current Protocols in Molecular Biology. Hoboken, NJ: John Wiley & Sons, 2006. DOI: 10.1002/0471142727.mb1500s73.
11. Gaunitz F, Papke M. Gene transfer and expression. Methods Mol Biol 1998;107:361-370.
12. Sandaltzopoulos R, Becker PB. Solid phase DNase I footprinting: quick and versatile. Nucleic Acids Res 1994;22:1511-1512.
13. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
14. Hecht A, Stemmler MP. Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4. J Biol Chem 2003;278:3776-3785.
15. Gaunitz F, Gaunitz C, Papke M, Gebhardt R. Cis-regulatory sequences from the first intron of the rat glutamine synthetase gene are involved in hepatocyte specific expression of the enzyme. Biol Chem 1997;378:11-18.
16. Shin D, Park S, Park C. A splice variant acquiring an extra transcript leader region decreases the translation of glutamine synthetase gene. Biochem J 2003;374:175-184.
17. Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci U S A 1997;94:7239-7244.
18. Azam M, Lee C, Strehlow I, Schindler C. Functionally distinct isoforms of STAT5 are generated by protein processing. Immunity 1997;6:691-701.
19. Paukku K, Silvennoinen O. STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5. Cytokine Growth Factor Rev 2004;15:435-455.
20. Wong BS, Chenoweth ME, Dunn A. Possible growth hormone control of liver glutamine synthetase activity in rats. Endocrinology 1980;106:268-274.
21. Wong BS, Dunn A. Possible growth hormone regulation of rat liver glutamine synthetase activity. Biochem Biophys Res Commun 1977;79:876-884.
22. Gebhardt R, Mecke D. Role of growth-hormone, dexamethasone and triiodothyronine in the regulation of glutamine-synthetase in primary cultures of rat hepatocytes. Eur J Biochem 1979;100:519-525.
23. Chatelain A, Dupouy JP, Dubois MP. Ontogenesis of cells producing polypeptide hormones (ACTH, MSH, LPH, GH, prolactin) in the fetal hypophysis of the rat: influence of the hypothalamus. Cell Tissue Res 1979;196:409-427.
24. Gaasbeek Janzen JW, Gebhardt R, ten Voorde GH, Lamers WH, Charles R, Moorman AF. Heterogeneous distribution of glutamine synthetase during rat liver development. J Histochem Cytochem 1987;35:49-54.
25. Gebert CA, Park SH, Waxman DJ. Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation. Mol Endocrinol 1997;11:400-414.
26. Sirma H, Williams GM, Gebhardt R. Strain- and sex-specific variations in hepatic glutamine synthetase activity and distribution in rats and mice. Liver 1996;16:166-173.
27. Waterman ML. Lymphoid enhancer factor/T cell factor expression in colorectal cancer. Cancer Metastasis Rev 2004;23:41-52.
28. Miller JR, Moon RT. Analysis of the signaling activities of localization mutants of beta-catenin during axis specification in Xenopus. J Cell Biol 1997;139:229-243.
29. Novak A, Dedhar S. Signaling through beta-catenin and Lef/Tcf. Cell Mol Life Sci 1999;56:523-537.
30. Colnot S, Decaens T, Niwa-Kawakita M, Godard C, Hamard G, Kahn A, et al. Liver-targeted disruption of Ape in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A 2004;101:17216-17221.