메뉴 건너뛰기




Volumn 374, Issue 1, 2003, Pages 175-184

A splice variant acquiring an extra transcript leader region decreases the translation of glutamine synthetase gene

Author keywords

Alternative splicing; Glutamine synthetase; Translational regulation; Untranslated region

Indexed keywords

CONFORMATIONS; CYTOLOGY; ENZYME KINETICS; MUTAGENESIS;

EID: 0042827851     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030132     Document Type: Article
Times cited : (21)

References (44)
  • 1
    • 77956944529 scopus 로고
    • Glutamine synthetase of mammals
    • Boyer, P. D., ed. Academic Press, London
    • Meister, A. (1974) Glutamine synthetase of mammals. In The Enzymes, vol. X (Boyer, P. D., ed.), pp. 699-754, Academic Press, London
    • (1974) The Enzymes , vol.10 , pp. 699-754
    • Meister, A.1
  • 2
    • 0000683935 scopus 로고
    • Glutamate and glutamine
    • Lajtha, A., ed. Plenum, New York
    • Van den Berg, C. J. (1970) Glutamate and glutamine. In Handbook of Neurochemistry, vol. III (Lajtha, A., ed.), pp. 355-379, Plenum, New York
    • (1970) Handbook of Neurochemistry , vol.3 , pp. 355-379
    • Van Den Berg, C.J.1
  • 5
    • 0031011669 scopus 로고    scopus 로고
    • Glutamine synthetase protects against neuronal degeneration in injured retinal tissue
    • Gorovits, R., Avidan, N., Avisar, N., Shaked, I. and Vardimon, L. (1997) Glutamine synthetase protects against neuronal degeneration in injured retinal tissue. Proc. Natl. Acad. Sci. U.S.A. 94, 7024-7029
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 7024-7029
    • Gorovits, R.1    Avidan, N.2    Avisar, N.3    Shaked, I.4    Vardimon, L.5
  • 6
    • 0027080730 scopus 로고
    • Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: A potential diagnostic biochemical marker
    • Gunnersen, D. and Haley, B. (1992) Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: a potential diagnostic biochemical marker. Proc. Natl. Acad. Sci. U.S.A 89, 11949-11953
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 11949-11953
    • Gunnersen, D.1    Haley, B.2
  • 7
    • 0034660602 scopus 로고    scopus 로고
    • Glutamine synthetase, hemoglobin α-chain, and macrophage migration inhibitory factor binding to amyloid β-protein: Their identification in rat brain by a novel affinity chromatography and in Alzheimer's disease brain by immunoprecipitation
    • Oyama, R., Yamamoto, H. and Titani, K. (2000) Glutamine synthetase, hemoglobin α-chain, and macrophage migration inhibitory factor binding to amyloid β-protein: their identification in rat brain by a novel affinity chromatography and in Alzheimer's disease brain by immunoprecipitation. Biochim. Biophys. Acta 1479, 91-102
    • (2000) Biochim. Biophys. Acta , vol.1479 , pp. 91-102
    • Oyama, R.1    Yamamoto, H.2    Titani, K.3
  • 8
    • 0033963901 scopus 로고    scopus 로고
    • Neuronal expression of glutamine synthetase in Alzheimer's disease indicates a profound impairment of metabolic interactions with astrocytes
    • Robinson, S. R. (2000) Neuronal expression of glutamine synthetase in Alzheimer's disease indicates a profound impairment of metabolic interactions with astrocytes. Neurochem. Int. 36, 471-482
    • (2000) Neurochem. Int. , vol.36 , pp. 471-482
    • Robinson, S.R.1
  • 9
    • 0025363344 scopus 로고
    • Interactions between glutamatergic and monoaminergic systems within the basal ganglia - Implications for schizophrenia and Parkinson's disease
    • Carlsson, M. and Carlsson, A. (1990) Interactions between glutamatergic and monoaminergic systems within the basal ganglia - implications for schizophrenia and Parkinson's disease. Trends Neurosci. 13, 272-276
    • (1990) Trends Neurosci. , vol.13 , pp. 272-276
    • Carlsson, M.1    Carlsson, A.2
  • 10
    • 0024380839 scopus 로고
    • Mouse glutamine synthetase is encoded by a single gene that can be expressed in a localized fashion
    • Kuo, C. F. and Darnell, Jr, J. E. (1989) Mouse glutamine synthetase is encoded by a single gene that can be expressed in a localized fashion. J. Mol. Biol. 208, 45-56
    • (1989) J. Mol. Biol. , vol.208 , pp. 45-56
    • Kuo, C.F.1    Darnell J.E., Jr.2
  • 13
    • 0030588067 scopus 로고    scopus 로고
    • Chromosomal mapping of a family of human glutamine synthetase genes: Functional gene (GLUL) on 1q25, pseudogene (GLULP) on 9p13, and three related genes (GLULL1, GLULL2, GLULL3) on 5q33, 11p15, and 11q24
    • Wang, Y., Kudoh, J., Kubota, R., Asakawa, S., Minoshima, S. and Shimizu, N. (1996) Chromosomal mapping of a family of human glutamine synthetase genes: functional gene (GLUL) on 1q25, pseudogene (GLULP) on 9p13, and three related genes (GLULL1, GLULL2, GLULL3) on 5q33, 11p15, and 11q24. Genomics 37, 195-199
    • (1996) Genomics , vol.37 , pp. 195-199
    • Wang, Y.1    Kudoh, J.2    Kubota, R.3    Asakawa, S.4    Minoshima, S.5    Shimizu, N.6
  • 15
    • 0027336722 scopus 로고
    • Identification and functional characterization of regulatory elements of the glutamine synthetase gene from rat liver
    • Fahrner, J., Labruyere, W. T., Gaunitz, C., Moorman, A. F. M., Gebhardt, R. and Lamers, W. H. (1993) Identification and functional characterization of regulatory elements of the glutamine synthetase gene from rat liver. Eur. J. Biochem. 213, 1067-1073
    • (1993) Eur. J. Biochem. , vol.213 , pp. 1067-1073
    • Fahrner, J.1    Labruyere, W.T.2    Gaunitz, C.3    Moorman, A.F.M.4    Gebhardt, R.5    Lamers, W.H.6
  • 16
  • 17
    • 0030963739 scopus 로고    scopus 로고
    • Elements in the distal 5′-flanking sequence and the first intron function cooperatively to regulate glutamine synthetase transcription during adipocyte differentiation
    • Hadden, T. J., Ryou, C. and Miller, R. E. (1997) Elements in the distal 5′-flanking sequence and the first intron function cooperatively to regulate glutamine synthetase transcription during adipocyte differentiation. Nucleic Acids Res. 25, 3930-3936
    • (1997) Nucleic Acids Res. , vol.25 , pp. 3930-3936
    • Hadden, T.J.1    Ryou, C.2    Miller, R.E.3
  • 18
    • 0034816246 scopus 로고    scopus 로고
    • Identification of a cis-acting element and a novel trans-acting factor of the glutamine synthetase gene in liver cells
    • Gaunitz, F., Weber, S., Scheja, L. and Gebhardt, R. (2001) Identification of a cis-acting element and a novel trans-acting factor of the glutamine synthetase gene in liver cells. Biochem. Biophys. Res. Commun. 284, 377-383
    • (2001) Biochem. Biophys. Res. Commun. , vol.284 , pp. 377-383
    • Gaunitz, F.1    Weber, S.2    Scheja, L.3    Gebhardt, R.4
  • 19
    • 0031057135 scopus 로고    scopus 로고
    • Cis-regulatory sequences from the first intron of the rat glutamine synthetase gene are involved in hepatocyte specific expression of the enzyme
    • Gaunitz, F., Gaunitz, C., Papke, M. and Gebhardt, R. (1997) Cis-regulatory sequences from the first intron of the rat glutamine synthetase gene are involved in hepatocyte specific expression of the enzyme. Biol. Chem. 378, 11-18
    • (1997) Biol. Chem. , vol.378 , pp. 11-18
    • Gaunitz, F.1    Gaunitz, C.2    Papke, M.3    Gebhardt, R.4
  • 20
    • 0019165434 scopus 로고
    • Dibutyryl cyclic AMP decreases glutamine synthetase in cultured 3T3-L1 adipocytes
    • Miller, R. E. and Carrino, D. A. (1980) Dibutyryl cyclic AMP decreases glutamine synthetase in cultured 3T3-L1 adipocytes. J. Biol. Chem. 255, 5490-5500
    • (1980) J. Biol. Chem. , vol.255 , pp. 5490-5500
    • Miller, R.E.1    Carrino, D.A.2
  • 21
    • 0034256020 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing: The logic of combinatorial control
    • Smith, C. W. J. and Valcárcel, J. (2000) Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem. Sci. 25, 381-388
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 381-388
    • Smith, C.W.J.1    Valcárcel, J.2
  • 22
    • 0036280885 scopus 로고    scopus 로고
    • A proinsulin gene splice variant with increased translation efficiency is expressed in human pancreatic islets
    • Shalev, A., Blair, P. J., Hoffmann, S. C., Hirshberg, B., Peculis, B. A. and Harlan, D. M. (2002) A proinsulin gene splice variant with increased translation efficiency is expressed in human pancreatic islets. Endocrinology 143, 2541-2547
    • (2002) Endocrinology , vol.143 , pp. 2541-2547
    • Shalev, A.1    Blair, P.J.2    Hoffmann, S.C.3    Hirshberg, B.4    Peculis, B.A.5    Harlan, D.M.6
  • 23
    • 0035846946 scopus 로고    scopus 로고
    • Post-transcriptional regulation of the GLI1 oncogene by the expression of alternative 5′ untranslated regions
    • Wang, X. and Rothnagel, J. A. (2001) Post-transcriptional regulation of the GLI1 oncogene by the expression of alternative 5′ untranslated regions. J. Biol. Chem. 276, 1311-1316
    • (2001) J. Biol. Chem. , vol.276 , pp. 1311-1316
    • Wang, X.1    Rothnagel, J.A.2
  • 24
    • 0037163090 scopus 로고    scopus 로고
    • Regulated translation of heparan sulfate GlcNAc N-deacetylase/N-sulfotransferase isozymes by structured 5′-untranslated regions and internal ribosome entry sites
    • Grobe, K. and Esko, J. D. (2002) Regulated translation of heparan sulfate GlcNAc N-deacetylase/N-sulfotransferase isozymes by structured 5′-untranslated regions and internal ribosome entry sites. J. Biol. Chem. 277, 30699-30706
    • (2002) J. Biol. Chem. , vol.277 , pp. 30699-30706
    • Grobe, K.1    Esko, J.D.2
  • 25
    • 0032926315 scopus 로고    scopus 로고
    • Neuronal NOS: Gene structure, mRNA diversity, and functional relevance
    • Wang, Y., Newton, D. C. and Marsden, P. A. (1999) Neuronal NOS: gene structure, mRNA diversity, and functional relevance. Crit. Rev. Neurobiol. 13, 21-43
    • (1999) Crit. Rev. Neurobiol. , vol.13 , pp. 21-43
    • Wang, Y.1    Newton, D.C.2    Marsden, P.A.3
  • 26
    • 0023665902 scopus 로고
    • An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
    • Kozak, M. (1987) An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15, 8125-8148
    • (1987) Nucleic Acids Res. , vol.15 , pp. 8125-8148
    • Kozak, M.1
  • 27
    • 0026342613 scopus 로고
    • An analysis of vertebrate mRNA sequences: Intimations of translational control
    • Kozak, M. (1991) An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell Biol. 115, 887-903
    • (1991) J. Cell Biol. , vol.115 , pp. 887-903
    • Kozak, M.1
  • 28
    • 0025792297 scopus 로고
    • Structural features in eukaryotic mRNAs that modulate the initiation of translation
    • Kozak, M. (1991) Structural features in eukaryotic mRNAs that modulate the initiation of translation. J. Biol. Chem. 266, 19867-19870
    • (1991) J. Biol. Chem. , vol.266 , pp. 19867-19870
    • Kozak, M.1
  • 29
    • 0030213227 scopus 로고    scopus 로고
    • Interpreting cDNA sequences: Some insights from studies on translation
    • Kozak, M. (1996) Interpreting cDNA sequences: some insights from studies on translation. Mamm. Genome 7, 563-574
    • (1996) Mamm. Genome , vol.7 , pp. 563-574
    • Kozak, M.1
  • 30
    • 0034459468 scopus 로고    scopus 로고
    • Upstream open reading frames as regulators of mRNA translation
    • Morris, D. R. and Geballe, A. P. (2000) Upstream open reading frames as regulators of mRNA translation. Mol. Cell. Biol. 20, 8635-8642
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8635-8642
    • Morris, D.R.1    Geballe, A.P.2
  • 31
    • 0034212658 scopus 로고    scopus 로고
    • The chicken c-Jun 5′ untranslated region directs translation by internal initiation
    • Sehgal, A., Briggs, J., Rinehart-Kim, J., Basso, J. and Bos, T. J. (2000) The chicken c-Jun 5′ untranslated region directs translation by internal initiation. Oncogene 19, 2836-2845
    • (2000) Oncogene , vol.19 , pp. 2836-2845
    • Sehgal, A.1    Briggs, J.2    Rinehart-Kim, J.3    Basso, J.4    Bos, T.J.5
  • 32
    • 0035963547 scopus 로고    scopus 로고
    • Cap-independent translation conferred by the 5′-untranslated region of human thymidine kinase mRNA
    • Chou, W. L. and Chang, Z. F. (2001) Cap-independent translation conferred by the 5′-untranslated region of human thymidine kinase mRNA. Biochim. Biophys. Acta 1519, 209-215
    • (2001) Biochim. Biophys. Acta , vol.1519 , pp. 209-215
    • Chou, W.L.1    Chang, Z.F.2
  • 33
    • 0028145741 scopus 로고
    • 2-adrenergic receptor mRNA inhibits receptor synthesis
    • 2-adrenergic receptor mRNA inhibits receptor synthesis. J. Biol. Chem. 269, 4497-4505
    • (1994) J. Biol. Chem. , vol.269 , pp. 4497-4505
    • Parola, A.L.1    Kobilka, B.K.2
  • 35
    • 0035122830 scopus 로고    scopus 로고
    • Inhibition of corticotropin releasing hormone type-1 receptor translation by an upstream AUG triplet in the 5′ untranslated region
    • Xu, G., Rabadan-Diehl, C., Nikodemova, M., Wynn, P., Spiess, J. and Aguilera, G. (2001) Inhibition of corticotropin releasing hormone type-1 receptor translation by an upstream AUG triplet in the 5′ untranslated region. Mol. Pharmacol. 59, 485-492
    • (2001) Mol. Pharmacol. , vol.59 , pp. 485-492
    • Xu, G.1    Rabadan-Diehl, C.2    Nikodemova, M.3    Wynn, P.4    Spiess, J.5    Aguilera, G.6
  • 36
    • 0035008872 scopus 로고    scopus 로고
    • New ways of initiating translation in eukaryotes?
    • Kozak, M. (2001) New ways of initiating translation in eukaryotes? Mol. Cell. Biol. 21, 1899-1907
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1899-1907
    • Kozak, M.1
  • 37
    • 0032176078 scopus 로고    scopus 로고
    • The complete nucleotide sequence of the domestic dog (Canis familiaris) mitochondrial genome
    • Kim, K. S., Lee, S. E., Jeong, H. W. and Ha, J. H. (1998) The complete nucleotide sequence of the domestic dog (Canis familiaris) mitochondrial genome. Mol. Phylogenet. Evol. 10, 210-220
    • (1998) Mol. Phylogenet. Evol. , vol.10 , pp. 210-220
    • Kim, K.S.1    Lee, S.E.2    Jeong, H.W.3    Ha, J.H.4
  • 38
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 40
    • 0029152189 scopus 로고
    • cRACE: A simple method for identification of the 5′ end of mRNAs
    • Maruyama, I. N., Rakow, T. L. and Maruyama, H. I. (1995) cRACE: a simple method for identification of the 5′ end of mRNAs. Nucleic Acids Res. 23, 3796-3797
    • (1995) Nucleic Acids Res. , vol.23 , pp. 3796-3797
    • Maruyama, I.N.1    Rakow, T.L.2    Maruyama, H.I.3
  • 41
    • 0024477261 scopus 로고
    • On finding all suboptimal folding of an RNA molecule
    • Zuker, M. (1989) On finding all suboptimal folding of an RNA molecule. Science 244, 48-52
    • (1989) Science , vol.244 , pp. 48-52
    • Zuker, M.1
  • 42
    • 0034781576 scopus 로고    scopus 로고
    • Presence of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates with a 'weak' context of the start codon
    • Rogozin, I. B., Kochetov, A. V., Kondrashov, F. A., Koonin, E. V. and Milanesi, L. (2001) Presence of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates with a 'weak' context of the start codon. Bioinformatics 17, 890-900
    • (2001) Bioinformatics , vol.17 , pp. 890-900
    • Rogozin, I.B.1    Kochetov, A.V.2    Kondrashov, F.A.3    Koonin, E.V.4    Milanesi, L.5
  • 43
    • 0029973094 scopus 로고    scopus 로고
    • Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells
    • Jacobson, A. and Peltz, S. W. (1996) Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu. Rev. Biochem. 65, 693-739
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 693-739
    • Jacobson, A.1    Peltz, S.W.2
  • 44
    • 0027968068 scopus 로고
    • CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighing, positions-specific gap penalties and weight matrix choice
    • Thompson, J. D., Higgins, D. G. and Gibson, T. J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighing, positions-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.