Effect of heparin affin regulatory peptide on the expression of vascular endothelial growth factor receptors in endothelial cells

In Vivo

Volumn 20, Issue 5, 2006, Pages 629-636

  Kokolakis, G ^a   Mikelis, C ^a   Papadimitriou, E ^a   Courty, J ^b   Karetsou, E ^a   Katsoris, P ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b Université Paris Val de Marne ^*  (France)

Author keywords

Endothelial cells; HARP; Pleiotrophin; VEGF; VEGF receptors

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; HEPARIN AFFIN REGULATORY PEPTIDE; MESSENGER RNA; NEUROPILIN 1; RECOMBINANT PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN 165; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CELL ACTIVATION; CELL COUNT; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN; WESTERN BLOTTING;

EID: 33750586740     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Papadimitriou E, Polykratis A, Hatziapostolou M, Parthymou A, Polytarchou C and Mikelis C: Heparin Affin Regulatory Peptide: A new target for tumour therapy? Curr Cancer Drug Targets 6: 471-482, 2004.
2. Milner PG, Li YS, Hoffman RM, Kodner CM, Siegel NR and Deuel TF: A novel 17 kD heparin-binding growth factor (HBGF-8) in bovine uterus: purification and N-terminal amino acid sequence. Biochern Biophys Res Commun 165: 1096-1103, 1989.
3. Rauvala H: An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factors. EMBO J 8: 2933-2941, 1989.
4. Hatziapostolou M, Delbe J, Katsoris P, Polytarchou C, Courty J and Papadimitriou E: Heparin affin regulatory peptide is a key player in prostate cancer cell growth and angiogenicity. Prostate 65: 151-158, 2005.
5. Lu KV, Jong KA, Kim GY, Singh J, Dia EQ, Yoshimoto K, Wang Y, Cloughesy TF, Nelson SF and Mischel PS: Differential induction of glioblastorna migration and growth by two forms of pleiotrophin. J Biol Chem 280: 26953-26964, 2005.
6. Papadimitriou E, Heroult M, Courty J, Polykratis A, Stergiou C and Katsoris P: Endothelial cell proliferation induced by HARP: Implication of N or C terminal peptides. Biochem Biophys Res Commun 274: 242-248, 2000.
7. Papadimitriou E, Polykratis A, Courty J, Koolwijk P, Heroult M and Katsoris P: HARP induces angiogenesis in vivo and in vitro: Implication of N or C terminal peptides. Biochem Biophys Res Commun 282: 306-313, 2001.
8. Polykratis A, Katsoris P, Courty J and Papadimitriou E: Characterization of heparin affin regulatory peptide signaling in human endothelial cells. J Biol Chem 280: 22454-22461, 2005.
9. Achour A, Laaroubi D, Caruelle D, Barritault D and Courty J: The angiogenic factor heparin affin regulatory peptide (HARP) induces proliferation of human peripheral blood mononuclear cells. Cell Mol Biol (Noisy-le-grand) 47(Online Pub): OL73-77, 2001.
10. Ferrara N: The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS 94: 209-231, 2005.
11. Hata Y, Rook SL and Aiello LP: Basic fibroblast growth factor induces expression of VEGF receptor KDR through a protein kinase C and p44/p42 mitogen-activated protein kinase- dependent pathway. Diabetes 48: 1145-1155, 1999.
12. Seghezzi G, Patel S, Ren CJ, Gualandris A, Pintucci G, Robbins ES, Shapiro Rl, Galloway AC, Rifkin DB and Mignatti P: Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J Cell Biol 141: 1659-1673, 1998.
13. Tsopanoglou NE and Maragoudakis ME: On the mechanism of thrombin-induced angiogenesis: potentiation of vascular endothelial growth factor activity on endothelial cells by up-regulation of its receptors. J Biol Chem 274: 23969-23976, 1999.
14. Tomanek RJ and Schatteman GC: Angiogenesis: New insights and therapeutic potential. Anat Rec 261: 126-135, 2000.
15. Veikkola T, Karkkainen M, Claesson-Welsh L and Alitalo K: Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res 60: 203-212, 2000.
16. Fong GH, Rossant J, Gertsenstein M and Breitman ML: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376: 66-70, 1995.
17. Shalaby F, Ho J, Stanford WL, Fischer KD, Schuh AC, Schwartz L, Bernstein A and Rossant J: A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogefiesis. Cell 89: 981-990, 1997.
18. Miao HQ and Klagsbrun M: Neuropilin is a mediator of angiogenesis. Cancer Metastasis Rev 19: 29-37, 2000.
19. Plouet J, Moro F, Bertagnolli S, Coldeboeuf N, Mazarguil H, Clamens S and Bayard F: Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect. J Biol Chem 272: 13390-13396, 1997.
20. Takahashi T and Shibuya M: The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 14: 2079-2089, 1997.
21. Heroult M, Bemard-Pierrot I, Delbe J, Hamma-Kourbali Y, Katsoris P, Barritault D, Papadimitriou E, Plouet J and Courty J: Heparin affin regulatory peptide binds to vascular endothelial growth factor (VEGF) and inhibits VEGF-indueed angiogenesis. Oncogene 23: 1745-1753, 2004.
22. Polykratis A, Delbe J, Courty J, Papadimitriou E and Katsoris P: Identification of heparin affin regulatory peptide domains with potential role on angiogenesis. Int J Biochern Cell Biol 36: 1964-1976, 2004.
23. Keyt BA, Nguyen HV, Berleau LT, Duarte CM, Park J, Chen H and Ferrara N: Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis. J Biol Chem 271: 5638-5646, 1996.
24. Koolwijk P, Peters E, Van der Vecht B, Homig C, Weich HA, Alitalo K, Hicklin DJ, Wu Y, Witte L and Van Hinsbergh VW: Involvement of VEGFR-2 (kdr/flk-1) but not VEGFR-1 (flt-1) in VEGF-A and VEGF-C-induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro. Angiogenesis 4: 53-60, 2001.
25. Zhang W, Ran S, Sambade M, Huang X and Thorpe PE: A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model. Angiogenesis 5: 35-44, 2002.
26. Hiratsuka S, Minowa O, Kuno J, Noda T and Shibuya M: Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci USA 95: 9349-9354, 1998.
27. Zeng H, Zhao D and Mukhopadhyay D: Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1. J Biol Chem 277: 4003-4009, 2002.
28. Roberts DM, Kearney JB, Johnson JH, Rosenberg MP, Kumar R and Bautch VL: The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation. Am J Pathol 64: 1531-1535, 2004.
29. Kearney JB, Ambler CA, Monaco KA, Johnson N, Rapoport RG and Bautch VL: Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division. Blood 99: 2397-2407, 2002.
30. Fuh G, Garcia KC and De Vos AM: The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1. J Biol Chem 275: 26690-26695, 2000.
31. Miao HQ, Lee P, Lin H, Soker S and Klagsbrun M: Neuropflin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J 14: 2532-2539, 2000.
32. Wang L, Zeng H, Wang P, Soker S and Mukhopadhyay D: Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration. J Biol Chem 278: 48848-48860, 2003.
33. Oh H, Takagi H, Otani A, Koyama S, Kemmochi S, Uemura A and Honda Y: Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis. Proc Natl Acad Sci USA 99: 383-388, 2002.