Development and evaluation of a DNA vaccine based on Helicobacter pylori urease B: Failure to prevent experimental infection in the mouse model

Helicobacter

Volumn 11, Issue 6, 2006, Pages 517-522

  Zavala Spinetti, Livania ^a   Breslin, Mary B ^b   Correa, Hernán ^b   Bégué, Rodolfo E ^a,b,c  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CHILDREN S HOSPITAL   (United States)

Author keywords

Animal experimentation; DNA vaccines; Helicobacter felis; Helicobacter pylori

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; DNA VACCINE; HELICOBACTER PYLORI VACCINE; IMMUNOLOGICAL ADJUVANT; PLASMID DNA; UNCLASSIFIED DRUG; UREASE; UREASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; ESCHERICHIA COLI; EUKARYOTE; EXPRESSION VECTOR; FEMALE; GENE AMPLIFICATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TREATMENT FAILURE;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ADMINISTRATION, RECTAL; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL VACCINES; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; IMMUNIZATION SCHEDULE; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; UREASE; VACCINATION; VACCINES; VACCINES, DNA;

ANIMALIA; ESCHERICHIA COLI; EUKARYOTA; HELICOBACTER FELIS; HELICOBACTER PYLORI;

EID: 33750573066     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2006.00453.x     Document Type: Article

References (27)

1. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002;347:1175-86.
2. Blanchard TG, Czinn SJ. Immunology of Helicobacter pylori and prospects for vaccine. Gastroenterol Clin North Am 2000;29:671-85.
3. Del Giudice G, Covacci A, Telford JL, Montecucco C, Rappuoli R. The design of vaccines against Helicobacter pylori and their development. Annu Rev Immunol 2001;19:523-63.
4. Eaton KA, Brooks CL, Morgan DR, Krakowka S. Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect Immun 1991;59:2470-5.
5. Futagami S, Takahashi H, Norose Y, Kobayashi M. Systemic and local immune responses against Helicobacter pylori urease in patients with chronic gastritis: distinct IgA and IgG productive sites. Gut 1998;43:168-75.
6. Michetti P, Corthésy-Theulaz I, Davin C, et al. Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology 1994;107:1002-11.
7. Ferrero RL, Thiberge JM, Huerre M, Labigne A. Recombinant antigens prepared from the urease subunits of Helicobacter spp: evidence of protection in a mouse model of gastric infection. Infect Imm 1994;62:4981-9.
8. Kreiss C, Buclin T, Cosma M, Corthésy-Theulaz I, Michetti P. Safety of oral immunization with recombinant urease in patients with Helicobacter pylori infection. Lancet 1996;347:1630-1.
9. Michetti P, Kreiss C, Kotloff KL, et al. Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in Helicobacter pylori-infected adults. Gastroenterology 1999;116:804-12.
10. Herrmann JE. DNA vaccines against enteric infections. Vaccine 2006;24:3705-8.
11. Robinson HL, Torres CA. DNA vaccines. Semin Immunol 1997;9:271-83.
12. Reyes-Sandoval A, Ertl HC. DNA vaccines. Curr Mol Med 2001;1:217-43.
13. Ozpolat B, Rao XM, Lachman LB, Osato MS, Graham DY. Quantitative and bioluminescent assay to measure efficacy of conventional and DNA vaccination against Helicobacter pylori. Comb Chem High Throughput Screen 2000;3:289-302.
14. Hatzifoti C, Bajaj-Elliot M, Dorrell N, et al. A plasmid immunization construct encoding urease B of Helicobacter pylori induces an antigen-specific antibody response and upregulates the expression of beta-defensins and IL-10 in the stomachs of immunized mice. Vaccine 2004;22:2651-9.
15. Dzwonek A, Mikula M, Woszczynski M, Henning E, Ostrowski J. Protective effect of vaccination with DNA of the H. pylori genomic library in experimentally infected mice. Cell Mol Biol Lett 2004;9:483-95.
16. Spinetti N, Zavala-Spinetti L, Hempe J, Correa H, Bégué RE. Effect of long-term Helicobacter felis infection in a mouse model of streptozotocin-induced diabetes. Helicobacter 2005;10:586-91.
17. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis - the updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston, 1994. Am J Surg Pathol 1996;20:1161-81.
18. Yang K, Wang S, Chang KO, et al. Immune responses and protection obtained with rotavirus VP6 DNA vaccines given by intramuscular injection. Vaccine 2001;19:3285-91.
19. Capozzo AV, Pistone Creydt V, Dran G, et al. Development of DNA vaccines against hemolytic-uremic syndrome in a murine model. Infect Immun 2003;71:3971-8.
20. Kojima Y, Xin KQ, Ooki T, et al. Adjuvant effect of multi-CpG motifs on an HIV-1 DNA vaccine. Vaccine 2002;20:2857-65.
21. Aggarwal P, Pandey RM, Seth P. Augmentation of HIV-1 subtype C vaccine constructs induced immune response in mice by CpG motif 1826-ODN. Viral Immunol 2005;18:213-23.
22. Choi AH, McNeal MM, Flint JA, et al. The level of protection against rotavirus shedding in mice following immunization with a chimeric VP6 protein is dependent on the route and the coadministered adjuvant. Vaccine 2002;20:1733-40.
23. Jiang W, Baker HJ, Smith BF. Mucosal immunization with Helicobacter, CpG DNA, and cholera toxin is protective. Infect Immun 2003;71:40-6.
24. Reddy DA, Bergmann CC, Meyer JC, et al. Rotavirus VP6 modified for expression on the plasma membrane forms arrays and exhibits enhanced immunogenicity. Virology 1992;189:423-34.
25. Ermak TH, Giannasca PJ, Nichols R, et al. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses. J Exp Med 1998;188:2277-88.
26. Ramshaw IA, Ramsay AJ. The prime-boost strategy: exciting prospects for improved vaccination. Immunol Today 2000;21:163-5.
27. Yuan L, Azevedo MS, Gonzalez AM, et al. Mucosal and systemic antibody responses and protection induced by a prime/boost rotavirus-DNA vaccine in a gnotobiotic pig model. Vaccine 2005;23:3925-36.