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Volumn 210, Issue 3, 2006, Pages 298-305

Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice

Author keywords

Animal model; Granuloma; Hypoxia; Necrosis; Persistence; Tuberculosis

Indexed keywords

NITRATE REDUCTASE; OXYGEN; PIMONIDAZOLE;

EID: 33750503812     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2055     Document Type: Article
Times cited : (151)

References (51)
  • 1
    • 17044394716 scopus 로고    scopus 로고
    • Global epidemiology of tuberculosis
    • Maher D, Raviglione M. Global epidemiology of tuberculosis. Clin Chest Med 2005;26:167-82.
    • (2005) Clin Chest Med , vol.26 , pp. 167-182
    • Maher, D.1    Raviglione, M.2
  • 2
    • 0842346271 scopus 로고    scopus 로고
    • The immunological aspects of latency in tuberculosis
    • Chan J, Flynn J. The immunological aspects of latency in tuberculosis. Clin Immunol 2004;110:2-12.
    • (2004) Clin Immunol , vol.110 , pp. 2-12
    • Chan, J.1    Flynn, J.2
  • 4
    • 11144250804 scopus 로고    scopus 로고
    • Tuberculosis - Metabolism and respiration in the absence of growth
    • Boshoff HI, Barry CE, III. Tuberculosis - metabolism and respiration in the absence of growth. Nat Rev Microbiol 2005;3:70-80.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 70-80
    • Boshoff, H.I.1    Barry III, C.E.2
  • 5
    • 0028603583 scopus 로고
    • Dormancy of Mycobacterium tuberculosis and latency of disease
    • Wayne LG. Dormancy of Mycobacterium tuberculosis and latency of disease. Eur J Clin Microbiol Infect Dis 1994;13:908-914.
    • (1994) Eur J Clin Microbiol Infect Dis , vol.13 , pp. 908-914
    • Wayne, L.G.1
  • 6
    • 2442711824 scopus 로고    scopus 로고
    • Persistent and dormant tubercle bacilli and latent tuberculosis
    • Zhang Y. Persistent and dormant tubercle bacilli and latent tuberculosis. Front Biosci 2004;9:1136-1156.
    • (2004) Front Biosci , vol.9 , pp. 1136-1156
    • Zhang, Y.1
  • 7
    • 25644456922 scopus 로고    scopus 로고
    • Exogenous reinfection in tuberculosis
    • Chiang CY, Riley LW. Exogenous reinfection in tuberculosis. Lancet Infect Dis 2005;5:629-636.
    • (2005) Lancet Infect Dis , vol.5 , pp. 629-636
    • Chiang, C.Y.1    Riley, L.W.2
  • 8
    • 0042863345 scopus 로고    scopus 로고
    • Latent tuberculosis: Mechanisms of host and bacillus that contribute to persistent infection
    • Tufariello JM, Chan J, Flynn JL. Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection. Lancet Infect Dis 2003;3:578-590.
    • (2003) Lancet Infect Dis , vol.3 , pp. 578-590
    • Tufariello, J.M.1    Chan, J.2    Flynn, J.L.3
  • 9
    • 0003132957 scopus 로고
    • Pathogenesis of pulmonary tuberculosis: An interplay of tissue-damaging and macrophage-activating immune responses - Dual mechanisms that control bacillary multiplication
    • In Bloom BR (ed). ASM Press: Washington, DC
    • Dannenberg AM, Rook GAW. Pathogenesis of pulmonary tuberculosis: an interplay of tissue-damaging and macrophage-activating immune responses - dual mechanisms that control bacillary multiplication. In Tuberculosis: Pathogenesis, Protection and Control, Bloom BR (ed). ASM Press: Washington, DC, 1994; 459-483.
    • (1994) Tuberculosis: Pathogenesis, Protection and Control , pp. 459-483
    • Dannenberg, A.M.1    Rook, G.A.W.2
  • 10
    • 0029976980 scopus 로고    scopus 로고
    • An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
    • Wayne LG, Hayes LG. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun 1996;64:2062-2069.
    • (1996) Infect Immun , vol.64 , pp. 2062-2069
    • Wayne, L.G.1    Hayes, L.G.2
  • 11
    • 0342794213 scopus 로고    scopus 로고
    • Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
    • McKinney JD, Honer zu BK, Munoz-Elias EJ, Miczak A, Chen B, Chan WT, et al. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature 2000;406:735-738.
    • (2000) Nature , vol.406 , pp. 735-738
    • McKinney, J.D.1    Honer zu, B.K.2    Munoz-Elias, E.J.3    Miczak, A.4    Chen, B.5    Chan, W.T.6
  • 12
    • 4544298326 scopus 로고    scopus 로고
    • A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
    • Reed MB, Domenech P, Manca C, Su H, Barczak AK, Kreiswirth BN, et al. A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature 2004;431:84-87.
    • (2004) Nature , vol.431 , pp. 84-87
    • Reed, M.B.1    Domenech, P.2    Manca, C.3    Su, H.4    Barczak, A.K.5    Kreiswirth, B.N.6
  • 13
    • 0038520795 scopus 로고    scopus 로고
    • The mouse as a useful model of tuberculosis
    • Orme IM. The mouse as a useful model of tuberculosis. Tuberculosis (Edinb) 2003;83:112-115.
    • (2003) Tuberculosis (Edinb) , vol.83 , pp. 112-115
    • Orme, I.M.1
  • 16
    • 0031442875 scopus 로고    scopus 로고
    • Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis
    • Rhoades ER, Frank AA, Orme IM. Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis. Tuber Lung Dis 1997;78:57-66.
    • (1997) Tuber Lung Dis , vol.78 , pp. 57-66
    • Rhoades, E.R.1    Frank, A.A.2    Orme, I.M.3
  • 17
    • 0028973209 scopus 로고
    • Mycobacterium tuberculosis is strikingly more virulent for mice when given via the respiratory than via the intravenous route
    • North RJ. Mycobacterium tuberculosis is strikingly more virulent for mice when given via the respiratory than via the intravenous route. J Infect Dis 1995;172:1550-1553.
    • (1995) J Infect Dis , vol.172 , pp. 1550-1553
    • North, R.J.1
  • 18
    • 0032873065 scopus 로고    scopus 로고
    • Different types of pulmonary granuloma necrosis in immunocompetent vs. TNFRp55-gene-deficient mice aerogenically infected with highly virulent Mycobacterium avium
    • Benini J, Ehlers EM, Ehlers S. Different types of pulmonary granuloma necrosis in immunocompetent vs. TNFRp55-gene-deficient mice aerogenically infected with highly virulent Mycobacterium avium. J Pathol 1999;189:127-137.
    • (1999) J Pathol , vol.189 , pp. 127-137
    • Benini, J.1    Ehlers, E.M.2    Ehlers, S.3
  • 19
    • 2542627386 scopus 로고    scopus 로고
    • Improved immunohistochemical method for detecting hypoxia gradients in mouse tissues and tumors
    • Samoszuk MK, Walter J, Mechetner E. Improved immunohistochemical method for detecting hypoxia gradients in mouse tissues and tumors. J Histochem Cytochem 2004;52:837-839.
    • (2004) J Histochem Cytochem , vol.52 , pp. 837-839
    • Samoszuk, M.K.1    Walter, J.2    Mechetner, E.3
  • 20
    • 0018872787 scopus 로고
    • Data acquisition and information processing in MDO oxygen electrode measurement of tissue oxygen pressure
    • Odman S, Lund N. Data acquisition and information processing in MDO oxygen electrode measurement of tissue oxygen pressure. Acta Anaesthesiol Scand 1980;24:161-165.
    • (1980) Acta Anaesthesiol Scand , vol.24 , pp. 161-165
    • Odman, S.1    Lund, N.2
  • 21
    • 20744449443 scopus 로고    scopus 로고
    • Brain oxygen monitoring: In-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors
    • Hoelper BM, Alessandri B, Heimann A, Behr R, Kempski O. Brain oxygen monitoring: in-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors. Acta Neurochir (Wien) 2005;147:767-774.
    • (2005) Acta Neurochir (Wien) , vol.147 , pp. 767-774
    • Hoelper, B.M.1    Alessandri, B.2    Heimann, A.3    Behr, R.4    Kempski, O.5
  • 22
    • 30744436820 scopus 로고    scopus 로고
    • Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis
    • Schreiber T, Ehlers S, Aly S, Holscher A, Hartmann S, Lipp M, et al. Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis. J Immunol 2006;176:1131-1140.
    • (2006) J Immunol , vol.176 , pp. 1131-1140
    • Schreiber, T.1    Ehlers, S.2    Aly, S.3    Holscher, A.4    Hartmann, S.5    Lipp, M.6
  • 23
    • 0037492815 scopus 로고    scopus 로고
    • Polymorphic nucleotide within the promoter of nitrate reductase (NarGHJI) is specific for Mycobacterium tuberculosis
    • Stermann M, Bohrssen A, Diephaus C, Maass S, Bange FC. Polymorphic nucleotide within the promoter of nitrate reductase (NarGHJI) is specific for Mycobacterium tuberculosis. J Clin Microbiol 2003;41:3252-3259.
    • (2003) J Clin Microbiol , vol.41 , pp. 3252-3259
    • Stermann, M.1    Bohrssen, A.2    Diephaus, C.3    Maass, S.4    Bange, F.C.5
  • 24
    • 0035904851 scopus 로고    scopus 로고
    • αβTCR + cells and IFNγ, but not iNOS, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology
    • Ehlers S, Benini J, Held HD, Roeck C, Alber G, Uhlig S. αβTCR + cells and IFNγ, but not iNOS, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology. J Exp Med 2001;194:1847-1859.
    • (2001) J Exp Med , vol.194 , pp. 1847-1859
    • Ehlers, S.1    Benini, J.2    Held, H.D.3    Roeck, C.4    Alber, G.5    Uhlig, S.6
  • 25
    • 0041736386 scopus 로고    scopus 로고
    • Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer
    • Bohle A, Brandau S. Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer. J Urol 2003;170:964-969.
    • (2003) J Urol , vol.170 , pp. 964-969
    • Bohle, A.1    Brandau, S.2
  • 26
    • 0032913318 scopus 로고    scopus 로고
    • Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin
    • Morgan SM, Samulowitz U, Darley L, Simmons DL, Vestweber D. Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin. Blood 1999;93:165-175.
    • (1999) Blood , vol.93 , pp. 165-175
    • Morgan, S.M.1    Samulowitz, U.2    Darley, L.3    Simmons, D.L.4    Vestweber, D.5
  • 27
    • 0032775305 scopus 로고    scopus 로고
    • Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method
    • Bishai WR, Dannenberg AM Jr, Parrish N, Ruiz R, Chen P, Zook BC, et al. Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method. Infect Immun 1999;67:4931-4934.
    • (1999) Infect Immun , vol.67 , pp. 4931-4934
    • Bishai, W.R.1    Dannenberg Jr., A.M.2    Parrish, N.3    Ruiz, R.4    Chen, P.5    Zook, B.C.6
  • 28
    • 0347091999 scopus 로고    scopus 로고
    • M. tuberculosis persistence, latency, and drug tolerance
    • Gomez JE, McKinney JD. M. tuberculosis persistence, latency, and drug tolerance. Tuberculosis (Edinb) 2004;84:29-44.
    • (2004) Tuberculosis (Edinb) , vol.84 , pp. 29-44
    • Gomez, J.E.1    McKinney, J.D.2
  • 29
    • 3042750016 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis gene expression during environmental conditions associated with latency
    • Voskuil MI. Mycobacterium tuberculosis gene expression during environmental conditions associated with latency. Tuberculosis (Edinb) 2004;84:138-143.
    • (2004) Tuberculosis (Edinb) , vol.84 , pp. 138-143
    • Voskuil, M.I.1
  • 30
    • 0037344575 scopus 로고    scopus 로고
    • Mechanisms of iron regulation in mycobacteria: Role in physiology and virulence
    • Rodriguez GM, Smith I. Mechanisms of iron regulation in mycobacteria: role in physiology and virulence. Mol Microbiol 2003;47:1485-1494.
    • (2003) Mol Microbiol , vol.47 , pp. 1485-1494
    • Rodriguez, G.M.1    Smith, I.2
  • 31
    • 0036270739 scopus 로고    scopus 로고
    • Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
    • Betts JC, Lukey PT, Robb LC, McAdam RA, Duncan K. Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol Microbiol 2002;43:717-731.
    • (2002) Mol Microbiol , vol.43 , pp. 717-731
    • Betts, J.C.1    Lukey, P.T.2    Robb, L.C.3    McAdam, R.A.4    Duncan, K.5
  • 33
    • 0034780485 scopus 로고    scopus 로고
    • Nonreplicating persistence of Mycobacterium tuberculosis
    • Wayne LG, Sohaskey CD. Nonreplicating persistence of Mycobacterium tuberculosis. Annu Rev Microbiol 2001;55:139-63.
    • (2001) Annu Rev Microbiol , vol.55 , pp. 139-163
    • Wayne, L.G.1    Sohaskey, C.D.2
  • 34
    • 0038349268 scopus 로고    scopus 로고
    • Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis
    • Park HD, Guinn KM, Harrell MI, Liao R, Voskuil MI, Tompa M, et al. Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis. Mol Microbiol 2003;48:833-843.
    • (2003) Mol Microbiol , vol.48 , pp. 833-843
    • Park, H.D.1    Guinn, K.M.2    Harrell, M.I.3    Liao, R.4    Voskuil, M.I.5    Tompa, M.6
  • 35
    • 0041827138 scopus 로고    scopus 로고
    • The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis
    • Ohno H, Zhu G, Mohan VP, Chu D, Kohno S, Jacobs WR Jr, et al. The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis. Cell Microbiol 2003;5:637-648.
    • (2003) Cell Microbiol , vol.5 , pp. 637-648
    • Ohno, H.1    Zhu, G.2    Mohan, V.P.3    Chu, D.4    Kohno, S.5    Jacobs Jr., W.R.6
  • 36
    • 0035936760 scopus 로고    scopus 로고
    • Microbial pathogenesis of Mycobacterium tuberculosis: Dawn of a discipline
    • Glickman MS, Jacobs WR Jr. Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline. Cell 2001;104:477-485.
    • (2001) Cell , vol.104 , pp. 477-485
    • Glickman, M.S.1    Jacobs Jr., W.R.2
  • 37
    • 0036081140 scopus 로고    scopus 로고
    • ideR, an essential gene in Mycobacterium tuberculosis: Role of ideR in iron-dependent gene expression, iron metabolism, and oxidative stress response
    • Rodriguez GM, Voskuil MI, Gold B, Schoolnik GK, Smith I. ideR, an essential gene in Mycobacterium tuberculosis: role of ideR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect Immun 2002;70:3371-3381.
    • (2002) Infect Immun , vol.70 , pp. 3371-3381
    • Rodriguez, G.M.1    Voskuil, M.I.2    Gold, B.3    Schoolnik, G.K.4    Smith, I.5
  • 38
    • 0043192889 scopus 로고    scopus 로고
    • The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice
    • Dahl JL, Kraus CN, Boshoff HI, Doan B, Foley K, Avarbock D, et al. The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice. Proc Natl Acad Sci USA 2003;100:10026-10031.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10026-10031
    • Dahl, J.L.1    Kraus, C.N.2    Boshoff, H.I.3    Doan, B.4    Foley, K.5    Avarbock, D.6
  • 39
    • 31844449080 scopus 로고    scopus 로고
    • Deletion of the Mycobacterium tuberculosis (alpha)-crystallin-like hspX gene causes increased bacterial growth in vivo
    • Hu Y, Movahedzadeh F, Stoker NG, Coates AR. Deletion of the Mycobacterium tuberculosis (alpha)-crystallin-like hspX gene causes increased bacterial growth in vivo. Infect Immun 2006;74:861-868.
    • (2006) Infect Immun , vol.74 , pp. 861-868
    • Hu, Y.1    Movahedzadeh, F.2    Stoker, N.G.3    Coates, A.R.4
  • 40
    • 0037371176 scopus 로고    scopus 로고
    • Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis
    • Parish T, Smith DA, Kendall S, Casali N, Bancroft GJ, Stoker NG. Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis, Infect Immun 2003;71:1134-1140.
    • (2003) Infect Immun , vol.71 , pp. 1134-1140
    • Parish, T.1    Smith, D.A.2    Kendall, S.3    Casali, N.4    Bancroft, G.J.5    Stoker, N.G.6
  • 41
    • 10744233580 scopus 로고    scopus 로고
    • Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis
    • Malhotra V, Sharma D, Ramanathan VD, Shakila H, Saini DK, Chakravorty S, et al. Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. FEMS Microbiol Lett 2004;231:237-245.
    • (2004) FEMS Microbiol Lett , vol.231 , pp. 237-245
    • Malhotra, V.1    Sharma, D.2    Ramanathan, V.D.3    Shakila, H.4    Saini, D.K.5    Chakravorty, S.6
  • 42
    • 20944450448 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
    • Munoz-Elias EJ, McKinney JD. Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Nat Med 2005;11:638-644.
    • (2005) Nat Med , vol.11 , pp. 638-644
    • Munoz-Elias, E.J.1    McKinney, J.D.2
  • 43
    • 0344666693 scopus 로고    scopus 로고
    • Role of narK2X and narGHJI in hypoxic upregulation of nitrate reduction by Mycobacterium tuberculosis
    • Sohaskey CD, Wayne LG. Role of narK2X and narGHJI in hypoxic upregulation of nitrate reduction by Mycobacterium tuberculosis. J Bacteriol 2003;185:7247-7256.
    • (2003) J Bacteriol , vol.185 , pp. 7247-7256
    • Sohaskey, C.D.1    Wayne, L.G.2
  • 44
    • 0024324987 scopus 로고
    • Keynote address: Hypoxic cell radiosensitizers: Where next?
    • Brown JM. Keynote address: hypoxic cell radiosensitizers: where next? Int J Radiat Oncol Biol Phys 1989;16:987-993.
    • (1989) Int J Radiat Oncol Biol Phys , vol.16 , pp. 987-993
    • Brown, J.M.1
  • 45
    • 0028785458 scopus 로고
    • Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver
    • Arteel GE, Thurman RG, Yates JM, Raleigh JA. Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver. Br J Cancer 1995;72:889-895.
    • (1995) Br J Cancer , vol.72 , pp. 889-895
    • Arteel, G.E.1    Thurman, R.G.2    Yates, J.M.3    Raleigh, J.A.4
  • 46
    • 0032079903 scopus 로고    scopus 로고
    • Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state
    • Arteel GE, Thurman RG, Raleigh JA. Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state. Eur J Biochem 1998;253:743-750.
    • (1998) Eur J Biochem , vol.253 , pp. 743-750
    • Arteel, G.E.1    Thurman, R.G.2    Raleigh, J.A.3
  • 47
    • 33644832153 scopus 로고    scopus 로고
    • Characterization of the tuberculous granuloma in murine and human lungs: Cellular composition and relative tissue oxygen tension
    • Tsai MC, Chakravarty S, Zhu G, Xu J, Tanaka K, Koch C, et al. Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension. Cell Microbiol 2006;8:218-232.
    • (2006) Cell Microbiol , vol.8 , pp. 218-232
    • Tsai, M.C.1    Chakravarty, S.2    Zhu, G.3    Xu, J.4    Tanaka, K.5    Koch, C.6
  • 48
    • 0028024035 scopus 로고
    • Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis
    • Wayne LG, Sramek HA. Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis. Antimicrob Agents Chemother 1994;38:2054-2058.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 2054-2058
    • Wayne, L.G.1    Sramek, H.A.2
  • 49
    • 0031460924 scopus 로고    scopus 로고
    • Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis
    • Cooper AM, Callahan JE, Keen M, Belisle JT, Orme IM. Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis. Tuber Lung Dis 1997;78:67-73.
    • (1997) Tuber Lung Dis , vol.78 , pp. 67-73
    • Cooper, A.M.1    Callahan, J.E.2    Keen, M.3    Belisle, J.T.4    Orme, I.M.5
  • 50
    • 22344448429 scopus 로고    scopus 로고
    • Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice
    • Jung YJ, Ryan L, LaCourse R, North RJ. Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice. J Exp Med 2005;201:1915-1924.
    • (2005) J Exp Med , vol.201 , pp. 1915-1924
    • Jung, Y.J.1    Ryan, L.2    LaCourse, R.3    North, R.J.4


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