Functional characterization of the promoter for the mouse SPTLC2 gene, which encodes subunit 2 of serine palmitoyltransferase

FEBS Letters

Volumn 580, Issue 26, 2006, Pages 6217-6223

  Linn, Stephen C ^a   Andras, Lindsay M ^a   Kim, Hee Sook ^b   Wei, Jia ^a   Nagiec, M Marek ^c   Dickson, Robert C ^c   Merrill Jr , Alfred H ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b Kyungsung University   (South Korea)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Luciferase reporter construct; Serine palmitoyltransferase; Sphingolipid biosynthesis; Transcription

Indexed keywords

LUCIFERASE; SERINE PALMITOYLTRANSFERASE; SERINE PALMITOYLTRANSFERASE 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN 3T3; CONTROLLED STUDY; DNA FLANKING REGION; ENZYME SUBUNIT; GENE CONSTRUCT; GENE EXPRESSION; GENETIC CODE; MAMMAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; GENES, REPORTER; MICE; MUTAGENESIS; NIH 3T3 CELLS; PROMOTER REGIONS (GENETICS); PROTEIN SUBUNITS; REGULATORY ELEMENTS, TRANSCRIPTIONAL; SERINE C-PALMITOYLTRANSFERASE; TRANSCRIPTION, GENETIC; TRANSDUCTION, GENETIC;

MAMMALIA;

EID: 33750503656     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.10.025     Document Type: Article

References (44)

1. Hanada K. Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim. Biophys. Acta 1632 (2003) 16-30
2. Wei J., Tokumbo Y., Liepelt M., Momin A., Wang E., Hanada K., and Merrill A.H. In: Hirabayashi Y., Igarashi Y., and Merrill A.H. (Eds). Serine Palmitoyltransferase in Sphingolipid Biology (2006), Springer, Tokyo 25-47
3. Hanada K., Nishijima M., and Akamatsu Y. A temperature-sensitive mammalian cell mutant with thermolabile serine palmitoyltransferase for the sphingolipid biosynthesis. J. Biol. Chem. 265 (1990) 22137-22142
4. Chigorno V., Giannotta C., Ottico E., Sciannamblo M., Mikulak J., Prinetti A., and Sonnino S. Sphingolipid uptake by cultured cells: complex aggregates of cell sphingolipids with serum proteins and lipoproteins are rapidly catabolized. J. Biol. Chem. 280 (2005) 2668-2675
5. Adachi-Yamada T., Gotoh T., Sugimura I., Tateno M., Nishida Y., Onuki T., and Date H. De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs. Mol. Cell. Biol. 19 (1999) 7276-7286
6. Hojjati M.R., Li Z., and Jiang X.C. Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice. Biochim. Biophys. Acta 1737 (2005) 44-51
7. Bejaoui K., Wu C., Scheffler M.D., Haan G., Ashby P., Wu L., de Jong P., and Brown Jr. R.H. SPTLC1 is mutated in hereditary sensory neuropathy, type 1. Nat. Genet. 27 (2001) 261-262
8. Dawkins J.L., Hulme D.J., Brahmbhatt S.B., Auer-Grumbach M., and Nicholson G.A. Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I. Nat. Genet. 27 (2001) 309-312
9. Bejaoui K., Uchida Y., Yasuda S., Ho M., Nishijima M., Brown Jr. R.H., Holleran W.M., and Hanada K. Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis. J. Clin. Invest. 110 (2002) 1301-1308
10. Merrill Jr. A.H. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J. Biol. Chem. 277 (2002) 25843-25846
11. London E. How principles of domain formation in model membranes may explain ambiguities concerning lipid raft formation in cells. Biochim. Biophys. Acta 1746 (2005) 203-220
12. Nickel W., Brugger B., and Wieland F.T. Protein and lipid sorting between the endoplasmic reticulum and the Golgi complex. Semin. Cell Dev. Biol. 9 (1998) 493-501
13. Hakomori S.I. Cell adhesion/recognition and signal transduction through glycosphingolipid microdomain. Glycoconj. J. 17 (2000) 143-151
14. Chalfant C.E., and Spiegel S. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J. Cell Sci. 118 (2005) 4605-4612
15. Futerman A.H., and Hannun Y.A. The complex life of simple sphingolipids. EMBO Rep. 5 (2004) 777-782
16. Buede R., Rinker-Schaffer C., Pinto W.J., Lester R.L., and Dickson R.C. Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids. J. Bacteriol. 173 (1991) 4325-4332
17. 2+-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity. J. Biol. Chem. 269 (1994) 21480-21488
18. Nagiec M.M., Baltisberger J.A., Wells G.B., Lester R.L., and Dickson R.C. The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc. Natl. Acad. Sci. USA 91 (1994) 7899-7902
19. Hanada K., Hara T., Nishijima M., Kuge O., Dickson R.C., and Nagiec M.M. A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis. J. Biol. Chem. 272 (1997) 32108-32114
20. Weiss B., and Stoffel W. Human and murine serine-palmitoyl-CoA transferase - cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur. J. Biochem. 249 (1997) 239-247
21. Hanada K., Hara T., Fukasawa M., Yamaji A., Umeda M., and Nishijima M. Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine palmitoyltransferase. J. Biol. Chem. 273 (1998) 33787-33794
22. Hanada K., Hara T., and Nishijima M. Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques. J. Biol. Chem. 275 (2000) 8409-8415
23. Nagiec M.M., Lester R.L., and Dickson R.C. Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase. Gene 177 (1996) 237-241
24. Farrell A.M., Uchida Y., Nagiec M.M., Harris I.R., Dickson R.C., Elias P.M., and Holleran W.M. UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes. J. Lipid Res. 39 (1998) 2031-2038
25. Grether-Beck S., Timmer A., Felsner I., Brenden H., Brammertz D., and Krutmann J. Ultraviolet a-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis. J. Invest. Dermatol. 125 (2005) 545-553
26. Memon R.A., Holleran W.M., Uchida Y., Moser A.H., Grunfeld C., and Feingold K.R. Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin. J. Lipid Res. 42 (2001) 452-459
27. Memon R.A., Holleran W.M., Moser A.H., Seki T., Uchida Y., Fuller J., Shigenaga J.K., Grunfeld C., and Feingold K.R. Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin. Arterioscler. Thromb. Vasc. Biol. 18 (1998) 1257-1265
28. Tanno O., Ota Y., Kitamura N., Katsube T., and Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br. J. Dermatol. 143 (2000) 524-531
29. Waterston R.H., Lindblad-Toh K., Birney E., Rogers J., Abril J.F., Agarwal P., Agarwala R., Ainscough R., Alexandersson M., An P., Antonarakis S.E., Attwood J., Baertsch R., Bailey J., Barlow K., Beck S., Berry E., Birren B., Bloom T., Bork P., et al. Initial sequencing and comparative analysis of the mouse genome. Nature 420 (2002) 520-562
30. Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J., Devon K., Dewar K., Doyle M., FitzHugh W., Funke R., Gage D., Harris K., Heaford A., Howland J., Kann L., Lehoczky J., LeVine R., McEwan P., McKernan K., et al. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
31. Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., et al. Whole-genome shotgun assembly and comparison of human genome assemblies. Proc. Natl. Acad. Sci. USA 101 (2004) 1916-1921
32. Cormack B. Introduction of a point mutation by sequential PCR steps. In: Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Seidman J.G., Smith J.A., and Struhl K. (Eds). Current Protocols in Molecular Biology (1991), Wiley, New York 8.5.7-8.5.8
33. Heinemeyer T., Chen X., Karas H., Kel A.E., Kel O.V., Liebich I., Meinhardt T., Reuter I., Schacherer F., and Wingender E. Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms. Nucleic Acids Res. 27 (1999) 318-322
34. Lo K., and Smale S.T. Generality of a functional initiator consensus sequence. Gene 182 (1996) 13-22
35. Smale S.T., and Kadonaga J.T. The RNA polymerase II core promoter. Annu. Rev. Biochem. 72 (2003) 449-479
36. Roder K., Wolf S.S., Larkin K.J., and Schweizer M. Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1. Gene 234 (1999) 61-69
37. Lewis B.A., Kim T.K., and Orkin S.H. A downstream element in the human beta-globin promoter: evidence of extended sequence-specific transcription factor IID contacts. Proc. Natl. Acad. Sci. USA 97 (2000) 7172-7177
38. Lee D.H., Gershenzon N., Gupta M., Ioshikhes I.P., Reinberg D., and Lewis B.A. Functional characterization of core promoter elements: the downstream core element is recognized by TAF1. Mol. Cell. Biol. 25 (2005) 9674-9686
39. Suske G. The Sp-family of transcription factors. Gene 238 (1999) 291-300
40. Mantovani R. The molecular biology of the CCAAT-binding factor NF-Y. Gene 239 (1999) 15-27
41. Fung T.K., and Poon R.Y. A roller coaster ride with the mitotic cyclins. Semin. Cell Dev. Biol. 16 (2005) 335-342
42. Kolaczkowski M., Kolaczkowska A., Gaigg B., Schneiter R., and Moye-Rowley W.S. Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae. Eukaryot. Cell 3 (2004) 880-892
43. Venkataraman K., Riebeling C., Bodennec J., Riezman H., Allegood J.C., Sullards M.C., Merrill Jr. A.H., and Futerman A.H. Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. J. Biol. Chem. 277 (2002) 35642-35649
44. Riebeling C., Allegood J.C., Wang E., Merrill Jr. A.H., and Futerman A.H. Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J. Biol. Chem. 278 (2003) 43452-43459