RNA interference: Mechanisms of action and therapeutic consideration

Surgery

Volumn 140, Issue 5, 2006, Pages 719-725

  Rychahou, Piotr G ^a   Jackson, Lindsey N ^a   Farrow, Buckminster J ^a   Evers, B Mark ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; SMALL INTERFERING RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ACUTE HEPATITIS; ACUTE LYMPHOBLASTIC LEUKEMIA; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; BREAST CARCINOMA; CANCER THERAPY; CHRONIC HEPATITIS; CHRONIC MYELOID LEUKEMIA; COLORECTAL CANCER; DIGESTIVE SYSTEM CANCER; DRUG EFFICACY; DRUG POTENCY; FUNCTIONAL GENOMICS; GENE EXPRESSION REGULATION; GENE TARGETING; GENITAL HERPES; HUMAN; INFLAMMATORY DISEASE; LIVER CIRRHOSIS; LUNG CANCER; MALIGNANT NEOPLASTIC DISEASE; MAMMAL CELL; MOLECULAR DYNAMICS; NONVIRAL GENE THERAPY; OVARY CARCINOMA; PANCREAS CANCER; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROSTATE CANCER; RESPIRATORY TRACT INFECTION; REVIEW; RNA INTERFERENCE; RNA TRANSLATION; SEPSIS; THYROID CANCER; TRANSLATION REGULATION;

GENE THERAPY; HUMANS; INFLAMMATION; MICRORNAS; NEOPLASMS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 33750450911     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2006.03.009     Document Type: Review

References (12)

1. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., and Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
2. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
3. Tabara H., Sarkissian M., Kelly W.G., Fleenor J., Grishok A., Timmons L., et al. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell 99 (1999) 123-132
4. Aravin A.A., Lagos-Quintana M., Yalcin A., Zavolan M., Marks D., Snyder B., et al. The small RNA profile during Drosophila melanogaster development. Dev Cell 5 (2003) 337-350
5. Bertrand J.-R., Pottier M., Vekris A., Opolon P., Maksimenko A., and Malvy C. Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo. Biochem and Biophys Res Commun 296 (2002) 1000-1004
6. Hannon G.J., and Rossi J.J. Unlocking the potential of the human genome with RNA interference. Nature 431 (2004) 371-378
7. Elbashir S.M., Martinez J., Patkaniowska A., Lendeckel W., and Tuschl T. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. Embo J 20 (2001) 6877-6888
8. Tuschl T., Zamore P.D., Lehmann R., Bartel D.P., and Sharp P.A. Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev 13 (1999) 3191-3197
9. Ambros V. The functions of animal microRNAs. Nature 431 (2004) 350-355
10. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116 (2004) 281-297
11. Rychahou P.G., Murillo C.A., and Evers B.M. Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL). Surgery 138 (2005) 391-397
12. Rychahou P.G., Jackson L.N., Silva S.R., Rajaraman S., and Evers B.M. Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. Ann Surg 243 (2006) 833-842