HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway

Journal of Molecular Medicine

Volumn 84, Issue 11, 2006, Pages 967-973

  Laezza, Chiara ^a,b,d   Mazziotti, Gherardo ^b,c,d   Fiorentino, Laura ^a,b,d   Gazzerro, Patrizia ^a   Portella, Giuseppe ^d   Gerbasio, Diego ^d   Carella, Carlo ^c   Matarese, Giuseppe ^b   Bifulco, Maurizio ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b CNR   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Goiter; Lovastatin; Ras oncogene

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROPYLTHIOURACIL; SIMVASTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; GOITER; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; ONCOGENE RAS; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; RAT; THYROID CELL; THYROID GLAND; THYROID HORMONE SYNTHESIS; THYROID HYPERPLASIA; WESTERN BLOTTING;

ANIMALS; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GENE TRANSFER TECHNIQUES; GOITER; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERPLASIA; HYPERTROPHY; LOVASTATIN; MALE; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROPYLTHIOURACIL; PROTEIN ISOPRENYLATION; PROTEIN KINASE INHIBITORS; RAS PROTEINS; RATS; RATS, WISTAR; TERPENES; THYROID GLAND; THYROTROPIN;

EID: 33750441536     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-006-0079-8     Document Type: Article

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