Microsphere-based bioresorbable structures loaded with proteins for tissue regeneration applications

Journal of Biomedical Materials Research - Part A

Volumn 79, Issue 2, 2006, Pages 370-379

  Zilberman, Meital ^a   Shraga, Inbal ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Bioresorbable fibers; Controlled protein release; Microspheres; Poly(DL lactic co glycolic acid); Poly(L lactic acid)

Indexed keywords

DIFFUSION; EMULSIONS; ENZYME KINETICS; MIXING; PROTEINS; TISSUE;

BIORESORBABLE FIBERS; CONTROLLED PROTEIN RELEASE; MICROSPHERES; POLY(DL-LACTIC-CO-GLYCOLIC ACID); POLY(L-LACTIC ACID);

COMPOSITE MATERIALS;

HORSERADISH PEROXIDASE; MICROSPHERE; POLYGLACTIN; POLYLACTIC ACID; POLYMER; POLYVINYL ALCOHOL; PROTEIN; SURFACTANT;

ARTICLE; BIOMECHANICS; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DEGRADATION; DIFFUSION; DRUG DELIVERY SYSTEM; EMULSION; FIBER; MATERIAL COATING; PROTEIN CONTENT; PROTEIN SECRETION; TISSUE REGENERATION;

BIOCOMPATIBLE MATERIALS; DRUG DELIVERY SYSTEMS; HORSERADISH PEROXIDASE; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYMERS; PROTEINS; REGENERATION; TIME FACTORS; TISSUE ENGINEERING;

EID: 33750428961     PISSN: 00219304     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.30775     Document Type: Article

References (24)

1. Thomson RC, Shung AK, Yaszemski MJ, Mikos AG. Polymer scaffold processing. In: Lanza RP, Langer R, Vacanti J, editors. Principles of Tissue Engineering. New York: Academic Press; 2000. pp 251-262.
2. Levy Y, Zilberman M. Novel bioresorbable composite fiber structures loaded with proteins for tissue regeneration applications. J Biomed Mater Res A. In press.
3. Su SH, Landau CL, Chao RY, Timmons RB, Meidell RS, Tang L, Eberhart RC. Expandable bioresorbable endovascular stent with anti-platelet and anti-inflammation treatments. Circulation 2001;104:500-507.
4. Alikacem N, Yoshizawa T, Wilson C, Nelson KD. Quantitative MR imaging study of intravitreal sustained release of VEGF in rabbits. Invest Ophthalmol Vis Sci 2000;41:1561-1569.
5. Dunn RL, Lewis DH, Goodson JM. Monolithic fibers for controlled delivery of tetracycline. Proc Intern Symp Control Rel Bioact Mater 1982;9:157-163.
6. Dunn RL, English JP, Stoner WC, Potter AG, Perkins BH. Biodegradable fibers for the controlled release of tetracycline in treatment of peridontal disease. Proc Intern Symp Control Rel Bioact Mater 1987;14:289-294.
7. Dunn RL, Lewis DH, Beck LR. Fibrous polymer for the delivery of contraceptive steroids to the female reproductive track. In: Lewis DH, editor. Controlled Release of Pesticides and Pharmaceuticals. New York: Plenum; 1981. pp 125-146.
8. Eenink MDJ, Feijen J, Oligslanger J, Albers JHM, Rieke JC, Greidonus PJ. Biodegradable hollow fibers for the controlled release of hormones. J Controlled Release 1987;6:225-237.
9. Polacco G, Cascone MG, Lazzeri L, Ferrara S, Giusti P. Biodegradable hollow fibers containing drug-loaded nanoparticles as controlled release systems. Polym Int 2002;51:1464-1472.
10. Lazzeri L, Cascone MG, Quiriconi S, Morabito L, Giusti P. Biodegradable hollow microfibers to produce bioactive scaffolds. Polym Int 2005;54:101-107.
11. Nihant N, Schugens C, Grandfils C, Jerom R, Teyssie P. Polylactide microparticles prepared by double emulsion/evaporation technique. I. Effect of primary emulsion stability. Pharm Res 1994;11:1479-1484.
12. Yang YY, Chung TS, Bai XL, Chan WK. Effect of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double emulsion method. Chem Eng Sci 2000;55:2223-2236.
13. Yang YY, Chung TS, Ng NP. Morphology, drug distribution and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double emulsion solvent extraction/evaporation method. Biomaterials 2001;22:231-241.
14. Zhu KJ, Jiang HL, Du XY, Wang J, Xu WX, Liu SF. Preparation and characterization of hCG-loaded polylactide or poly(lactide-co-glycolide) microspheres using a modified water-in-oil-in-water (W/O/W) emulsion solvent evaporation technique. J Microencapsul 2001;18:247-260.
15. Jeffery H, Davis SS, O'Hagan DT. The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique. Pharm Res 1993;10:362-368.
16. Park TG, Lu W, Crotts G. Importance of in vitro experimental conditions on protein release kinetics, stability and polymer degradation in protein encapsulated poly(D,L-lactic acid-co-glycolic acid) microspheres. J Controlled Release 1995;33:211-222.
17. Sandor M, Enscore D, Weston P, Mathiowitz E. Effect of protein molecular weight on release from micron-sized PLGA microspheres. J Controlled Release 2001;76:297-311.
18. Ogawa Y, Yamamoto M, Okada H, Yashiki T, Shimamoto T. A new technique to efficiency entrap leuprolide acetate into microcapsules of copoly(lactic/ glycolic acid). Chem Pharm Bull 1998;36:1095-1103.
19. Woo BH, Jiang G, Jo YW, DeLuca PP. Preparation and characterization of a composite PLGA and poly(acryloyl hydroxyethyl starch) microsphere system for protein delivery. Pharm Res 2001;18:1600-1606.
20. Chia HH, Yang YY, Chung TS, Ng S, Heller J. Auto-catalyzed poly(ortho ester) microspheres: A study of their erosion and drug release mechanisms. J Controlled Release 2001;75:11-25.
21. Shraga I. Microsphere-Based Bioresorbable Structures Loaded with Proteins for Tissue Regeneration Applications. MSc Thesis, Tel-Aviv University, 2005.
22. Castellanos IJ, Crespo R, Griebenow K. Poly(ethylene glycol) as stabilizer and emulsifying agent: A novel stabilization approach preventing aggregation and inactivation of proteins upon encapsulation in bioerodible polyester microspheres. J Controlled Release 2003;88:135-145.
23. Kempen DHR, Lu L, Zhu X, Kim C, Jabbari E, Dhert WJA, Currier BL, Yaszemski MJ. Development of biodegradable poly(propylene furmarate)/ poly(lactic-co-glycolic acid) blend microspheres. II. Controlled drug release and microsphere degradation. J Biomed Mater Res A 2004;70:293-302.
24. Fu K, Harrell R, Zinski K, Um C, Jaklenec A, Frazier J, Lotan N, Burke P, Klibanov AM, Langer R. A potential approach for decreasing the burst effect of protein from PLGA microspheres. J Pharm Sci 2003;92:1582-1591.