A truncated alternative spliced isoform of human desmoglein 1 contains a specific T cell epitope binding to the pemphigus foliaceus-associated HLA class II DRβ1*0102 molecule

Journal of Immunology

Volumn 177, Issue 9, 2006, Pages 6517-6526

  Mouquet, Hugo ^a   Farci, Sandrine ^b   Joly, Pascal ^a   Maillère, Bernard ^b   Leblond, Jonathan ^a   Drouot, Laurent ^a   Leprince, Jérôme ^a   Tonon, Marie Christine ^a   Loiseau, Pascale ^a   Charron, Dominique ^a   Tron, François ^a   Gilbert, Danièle ^a  

^a INSERM   (France)

^b CEA SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; DESMOGLEIN; DESMOGLEIN 1; DESMOGLEIN 2; DESMOGLEIN 3; DESMOGLEIN 4; EPITOPE; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; UNCLASSIFIED DRUG;

ADULT; AGED; ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY COMBINING SITE; ARTICLE; AUTOIMMUNE SKIN DISEASE; BULLOUS SKIN DISEASE; CELL ADHESION; CLINICAL ARTICLE; CONTROLLED STUDY; DESMOSOME; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; FEMALE; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPATHOGENESIS; INTRON; KERATINOCYTE; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PEMPHIGUS FOLIACEUS; PEMPHIGUS VULGARIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; STOP CODON; T LYMPHOCYTE;

EID: 33750350280     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.9.6517     Document Type: Article

References (34)

1. Black, D. L. 2003. Mechanisms of alternative pre-messenger RNA splicing. Annu. Rev. Biochem. 72: 291-336.
2. Zinkernagel, R. M., and H. Hengartner. 2001. Regulation of the immune response by antigen. Science 293: 251-253.
3. Bach, J. F., S. Koutouzov, and P. M. van Endert. 1998. Are there unique autoantigens triggering autoimmune diseases? Immunol. Rev. 164: 139-155.
4. Klein, L., M. Klugmann, K. A. Nave, V. K. Tuohy, and B. Kyewski. 2000. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6: 56-61.
5. Diez, J., Y. Park, M. Zeller, D. Brown, D. Garza, C. Ricordi, J. Hutton, G. S. Eisenbarth, and A. Pugliese. 2001. Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen. Diabetes 50: 895-900.
6. Whittock, N. V., and C. Bower. 2003. Genetic evidence for a novel human desmosomal cadherin, desmoglein 4. J. Invest. Dermatol. 120: 523-530.
7. Schafer, S., P. J. Koch, and W. W. Franke. 1994. Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein sub-family of desmosomal cadherins. Exp. Cell. Res. 211: 391-399.
8. Amagai, M., K. Ishii, T. Hashimoto, S. Gamou, N. Shimizu, and T. Nishikawa. 1995. Conformational epitopes of pemphigus antigens (Dsg1 and Dsg3) are calcium dependent and glycosylation independent. J. Invest. Dermatol. 105: 243-247.
9. Emery, D. J., L. A. Diaz, J. A. Fairley, A. Lopez, A. F. Taylor, and G. J. Giudice. 1995. Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein 1. J. Invest. Dermatol. 104: 323-328.
10. Sekiguchi, M., Y. Futei, Y. Fujii, T. Iwasaki, T. Nishikawa, and M. Amagai. 2001. Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins. J. Immunol. 167: 5439-5448.
11. Roscoe, A., L. Diaz, S. A. Sampaio, R. M. Castro, R. S. Labib, Y. Takahashi, H. Patel, and G. J. Anhalt. 1985. Brazilian pemphigus foliaceus autoantibodies are pathogenic to BALB/c mice by passive transfer. J. Invest. Dermatol. 85: 538-541.
12. Amagai, M., T. Hashimoto, K. J. Green, N. Shimizu, and T. Nishikawa. 1995. Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus. J. Invest. Dermatol. 104: 895-901.
13. Ishii, K., M. Amagai, R. P. Hall, T. Hashimoto, A. Takayanagi, S. Gamou, N. Shimuzu, and T. Nishikawa. 1997. Characterization of autoantibodies in pemphigus using antigen-specific ELISAs with baculovirus-expressed recombinant desmogleins. J. Immunol. 159: 2010-2017.
14. Amagai, M., T. Nishikawa, H. C. Nousari, G. J. Anhalt, and T. Hashimoto. 1998. Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice. J. Clin. Invest. 102: 775-782.
15. Lin, M. S., C. L. Fu, V. Aoki, G. Hans-Filho, E. A. Rivitti, J. R. Moraes, M. E. Moraes, A. M. Lazaro, G. J. Giudice, P. Stastny, and L. A. Diaz. 2000. Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem). J. Clin. Invest. 105: 207-213.
16. Moraes, J. R., M. E. Moraes, M. Fernandez-Vina, L. A. Diaz, H. Friedman, I. T. Campbell, R. R. Alvarez, S. A. Sampaio, E. A. Rivitti, and P. Stastny. 1991. HLA antigens and risk for development of pemphigus foliaceus (fogo selvagem) in endemic areas of Brazil. Immunogenetics 33: 388-391.
17. Loiseau, P., L. Lecleach, C. Prost, V. Lepage, M. Busson, S. Bastuji-Garin, J. C. Roujeau, and D. Charron. 2000. HLA class II polymorphism contributes to specify desmoglein derived peptides in pemphigus vulgaris and pemphigus foliaceus. J. Autoimmun. 15: 67-73.
18. Miyagawa, S., M. Amagai, H. Niizeki, Y. Yamashina, T. Kaneshige, T. Nishikawa, T. Shirai, and H. Inoko. 1999. HLA-DRB1 polymorphisms and autoimmune responses to desmogleins in Japanese patients with pemphigus. Tissue Antigens 54: 333-340.
19. Martel, P., D. Gilbert, M. Busson, P. Loiseau, V. Lepage, L. Drouot, E. Delaporte, C. Prost, P. Joly, D. Charron, and F. Tron. 2000. Epistasis between DSG1 and HLA class II genes in pemphigus foliaceus. Genes Immun. 3: 205-210.
20. Vandenbroucke, I. I., J. Vandesompele, A. D. Paepe, and L. Messiaen. 2001. Quantification of splice variants using real-time PCR. Nucleic Acids Res. 29: e68.
21. Karsai, A., S. Muller, S. Platz, and M. T. Hauser. 2002. Evaluation of a home-made SYBR Green I reaction mixture for real-time PCR quantification of gene expression. BioTechniques 32: 790-792, 794-796.
22. Raaijmakers, M. H., L. Van Emst, T. De Witte, E. Mensink, and R. A. Raymakers. 2002. Quantitative assessment of gene expression in highly purified hematopoietic cells using real-time reverse transcriptase polymerase chain reaction. Exp. Hematol. 30: 481-487.
23. Wellmann, S., T. Taube, K. Paal, H. G. Von Einsiedel, W. Geilen, G. Seifert, C. Eckert, G. Henze, and K. Seeger. 2001. Specific reverse transcription-PCR quantification of vascular endothelial growth factor (VEGF) splice variants by LightCycler technology. Clin. Chem. 47: 654-660.
24. Marcucci, G., M. A. Caligiuri, H. Dohner, K. J. Archer, R. F. Schlenk, K. Dohner, E. A. Maghraby, and C. D. Bloomfield. 2001. Quantification of CBFβ/MYH11 fusion transcript by real-time RT-PCR in patients with INV(16) acute myeloid leukemia. Leukemia 15: 1072-1080.
25. Kallel Sellami, M., M. Ben Ayed, H. Mouquet, L. Drouot, M. Zitouni, M. Mokni, M. Cerruti, H. Turki, B. Fezza, I. Mokhtar, et al. 2004. Anti-desmoglein 1 antibodies in Tunisian healthy subjects: arguments for the role of environmental factors in the occurrence of Tunisian pemphigus foliaceus. Clin. Exp. Immunol. 137: 195-200.
26. Mouquet, H., L. Drouot, R. Charlionnet, C. Arnoult, F. Bonnet-Bayeux, M. Thomas, J. Leprince, P. Joly, F. Tron, and D. Gilbert. 2006. Proteomic analysis of the autoantibody response following immunization with a single autoantigen. Proteomics 6: 4829-4837.
27. Görg, A., C. Obermaier, G. Boguth, A. Csordas, J. J. Diaz, and J. J. Madjar. 1997. Very alkaline immobilized pH gradients for two-dimensional electrophoresis of ribosomal and nuclear proteins. Electrophoresis 18: 328-337.
28. Texier, C., S. Pouvelle, M. Busson, M. Herve, D. Charron, A. Menez, and B. Maillere. 2000. HLA-DR restricted peptide candidates for bee venom immunotherapy. J. Immunol. 164: 3177-3184.
29. Texier, C., S. Pouvelle-Moratille, M. Busson, D. Charron, A. Menez, and B. Maillere. 2001. Complementarity and redundancy of the binding specificity of HLA-DRB1, -DRB3, -DRB4 and -DRB5 molecules. Eur. J. Immunol. 31: 1837-1846.
30. Voskuhl, R. R., D. E. McFarlin, L. R. Tranquill, G. Deibler, R. Stone, H. Maloni, and H. F. McFarland. 1993. A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination. J. Neuroimmunol. 46: 137-144.
31. Pavoni, D. P., V. M. M. S. Roxo, A. Marquart Filho, and M. L. Petzl-Erler. 2003. Dissecting the associations of endemic pemphigus foliaceus (Fogo selvagem) with HLA-DRB1 alleles and genotypes. Genes Immun. 4: 110-116.
32. Ng, B., F. Yang, D. P. Huston, Y. Yan, Y. Yang, Z. Xiong, L. E. Peterson, H. Wang, and X. F. Yang. 2004. Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes. J. Allergy Clin. Immunol. 114: 1463-1470.
33. Serpente, N., C. Marcozzi, G. A. Roberts, Q. Bao, B. D. Angst, E. M. Hirst, I. D. Burdett, R. S. Buxton, and A. I. Magee. 2000. Extracellularly truncated desmoglein 1 compromises desmosomes in MDCK cells. Mol. Membr. Biol. 17: 175-183.
34. Tanaka, M., M. Kishimura, S. Ozaki, F. Osakada, H. Hashimoto, M. Okubo, M. Murakami, and K. Nakao. 2000. Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. J. Clin. Invest. 106: 137-144.