Extracellularly truncated desmoglein 1 compromises desmosomes in MDCK cells

Molecular Membrane Biology

Volumn 17, Issue 3, 2000, Pages 175-183

  Serpente, N ^a   Marcozzi, C ^a   Roberts, G A ^a   Bao, Q ^a   Angst, B D ^a   Hirst, E M A ^a   Burdett, I D J ^a   Buxton, R S ^a   Magee, A I ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Cell adhesion; Desmoglein; Desmosomes; Dominant negative; Epithelia

Indexed keywords

COLLAGEN; DESMOCOLLIN; DESMOGLEIN; DESMOGLEIN 1; DESMOPLAKIN; NERVE CELL ADHESION MOLECULE; PLAKOGLOBIN; PLAKOPHILIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL INCLUSION; CELL INTERACTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DESMOSOME; EPITHELIUM; MECHANICAL STRESS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALIA;

EID: 0033653588     PISSN: 09687688     EISSN: None     Source Type: Journal    
DOI: 10.1080/09687680010002238     Document Type: Article

References (57)

1. Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation and epidermal differentiation
2. Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant
3. Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma
4. Stratification-related expression of isoforms of the desmosomal cadherins in human epidermis
5. Galectin-3 expression and effects on cyst enlargement and tubulogenesis in kidney epithelial MDCK cells cultured in three-dimensional matrices in vitrol
6. Embyonic heart and skin defects in mice lacking plakoglobin
7. Breaking the connection; displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly
8. Internalization of desmosomes and their entry into the endocytic pathway via late endosomes in MDCK cells. Possible mechanisms for the modulation of cell adhesion by desmosomes during development
9. Aspects of the structure and assembly of desmosomes
10. Molecular organization of the desmogleinplakoglobin complex
11. The binding of plakoglobin to desmosomal cadherins: Patterns of binding sites and topogenic potential
12. Expression of the cytoplasmic domain of E-cadherin induces precocious mammary epithelial alveolar formation and affects cell polarity and cell-matrix integrity
13. Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: A coordinated sisyphyus cycle
14. Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin
15. Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage
16. Desmosomes and hemidesmosomes: Structure and function of molecular components
17. Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes
18. The function of plakophilin 1 in desmosome assembly and actin filament organisation
19. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
20. N-cadherin and impairment of cell-cell contact by a truncated N-cadherin mutant
21. Clustered cadherin genes: A sequence-ready contig for the desmosomal cadherin locus on human chromosome 18
22. Hierarchical expression of desmosomal cadherins during stratifield epithelial morphogenesis in the mouse
23. Desmosomal cadherins: Another growing multigene family of adhesion molecules
24. Targeted disruption of the pemphigus vulgaris antigen (Desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris
25. Analysis of desmosomal cadherin-adhesive function and stoichiometry of desmosomal cadherin-plakoglobin complexes
26. The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes
27. The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes: Implications for cutaneous disease
28. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
29. Transmembrane molecular assemblies regulated by the greater cadherin family
30. Coexpression of both types of desmosomal cadherin and plakoglobin confers strong intercellular adhesion
31. Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin
32. Mutations in the plakophilin 1 gene result in ectodermal dysplasia/skin fragility syndrome
33. Structural basis of calcium-induced E-cadherin rigidification and dimerization
34. Mechanism of extracellular domain-deleted dominant negative cadherins
35. Molecular map of the desmosomal plaque
36. Contributions of extracellular and intracellular domains of full length and chimeric cadherin molecules to junction assembly in epithelial cells
37. Roles of plakoglobin ends domains in desmosome assembly
38. Desmosomal glycoproteins II and III: Cadherin-like junctional molecules generated by alternative splicing
39. The assembly of the major desmosome glycoproteins of Madin-Darby canine kidney cells
40. 2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation
41. N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma
42. Antisense expression of a desmocollin gene in MDCK cells alters desmosome plaque assembly but does not affect desmoglein expression
43. Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
44. Uncoupling cadherin-based adhesion from wingless signalling in Drosophila
45. Desmosomes and hemidesmosomes: Constitutive molecular components
46. Structural basis of cell adhesion by cadherins
47. Defining the interactions between intermediate filaments and desmosomes
48. Cadherins and their connections: Adhesion junctions have broader functions
49. Mechanism of cell-cell adhesion complex assembly
50. Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage
51. Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage
52. Desmosomal adhesion inhibits invasive behaviour
53. A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen
54. Nonmitogenic morphoregulatory action of pp 60(v-src) on multicellular epithelial structures
55. Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules
56. Desmosomal cadherin binding domains of plakoglobin
57. Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes