The value of clinical findings and D-dimer tests in diagnosing deep vein thrombosis in primary care

Seminars in Thrombosis and Hemostasis

Volumn 32, Issue 7, 2006, Pages 673-677

  Oudega, Ruud ^a   Hoes, Arno W ^a   Toll, Diane B ^a   Moons, Karel G M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

D dimer; Deep vein thrombosis; Diagnosis; Diagnostic accuracy; Primary health care

Indexed keywords

D DIMER; ORAL CONTRACEPTIVE AGENT;

BUDGET; CANCER; CLINICAL FEATURE; DEEP VEIN THROMBOSIS; DIAGNOSTIC PROCEDURE; DIAGNOSTIC VALUE; GENDER; HUMAN; LEG INJURY; LUNG EMBOLISM; ORAL CONTRACEPTION; PATIENT REFERRAL; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS;

FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; MALE; PRIMARY HEALTH CARE; PROBABILITY; RISK FACTORS; VENOUS THROMBOSIS;

EID: 33750349807     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-951295     Document Type: Review

References (36)

1. Cranley JJ, Canos AJ, Sull WJ. The diagnosis of deep venous thrombosis. Fallibility of clinical symptoms and signs. Arch Surg 1976;111:34-36
2. Haeger K. Problems of acute deep venous thrombosis. I. The interpretation of signs and symptoms. Angiology 1969;20:219-223
3. Hirsh J, Hoak J. Management of deep vein thrombosis and pulmonary embolism. A statement for healthcare professionals. Council on Thrombosis (in consultation with the Council on Cardiovascular Radiology), American Heart Association. Circulation 1996;93:2212-2245
4. Wells PS, Anderson DR, Rodger M, et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med 2003;349:1227-1235
5. Cornuz J, Ghali WA, Hayoz D, Stoianov R, Depairon M, Yersin B. Clinical prediction of deep venous thrombosis using two risk assessment methods in combination with rapid quantitative D-dimer testing. Am J Med 2002;112:198-203
6. Kraaijenhagen RA, Piovella F, Bernardi E, et al. Simplification of the diagnostic management of suspected deep vein thrombosis. Arch Intern Med 2002;162:907-911
7. Perrier A, Desmarais S, Miron MJ, et al. Non-invasive diagnosis of venous thromboembolism in outpatients. Lancet 1999;353:190-195
8. Wells PS, Anderson DR, Bormanis J, et al. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet 1997;350:1795-1798
9. Landefeld CS, McGuire E, Cohen AM. Clinical findings associated with acute proximal deep vein thrombosis: a basis for quantifying clinical judgment. Am J Med 1990;88:382-388
10. Constans J, Nelzy ML, Salmi LR, et al. Clinical prediction of lower limb deep vein thrombosis in symptomatic hospitalized patients. Thromb Haemost 2001;86:985-990
11. Goodacre S, Sutton AJ, Sampson FC. Metaanalysis: the value of clinical assessment in the diagnosis of deep venous thrombosis. Ann Intern Med 2005;143:129-139
12. Oudega R, Moons KGM, Hoes AW. Ruling out deep venous thrombosis in primary cafe: a simple diagnostic algorithm including D-dimer testing. Thromb Haemost 2005;94:200-205
13. Schutgens REG, Ackermark P, Haas FJLM, et al. Combination of a normal D-dimer concentration and a non-high pretest clinical probability score is a safe strategy to exclude deep venous thrombosis. Circulation 2003;107:593-597
14. Kearon C, Ginsberg JS, Douketis J, et al. Management of suspected deep venous thrombosis in outpatients by using clinical assessment and D-dimer testing. Ann Intern Med 2001;135:108-111
15. Anderson DR, Kovacs MJ, Kovacs G, et al. Combined use of clinical assessment and D-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis (the EDITED Study). J Thromb Haemost 2003;1:645-651
16. Knottnerus JA. Between iatrotropic stimulus and interiatric referral: the domain of primary care research. J Clin Epidemiol 2002;55:1201-1206
17. Ransohoff D, Feinstein AR. Problems of spectrum and bias in evaluating the efficacy of diagnostic tests. N Engl J Med 1978;299:926-930
18. Knottnerus JA, Leffers P. The influence of referral patterns on the characteristics of diagnostic tests. J Clin Epidemiol 1992;45:1143-1154
19. Knottnerus JA, Muris JW. Assessment of the accuracy of diagnostic tests: the cross-sectional study. J Clin Epidemiol 2003;56:1118-1128
20. van der Schouw YT, van der Graaf Y, Steyerberg EW, Eijkemans JC, Banga JD. Age at menopause as a risk factor for cardiovascular mortality. Lancet 1996;347:714-718
21. Begg CB, Greenes RA. Assessment of diagnostic tests when disease verification is subject to selection bias. Biometrics 1983;39:207-215
22. Heim SW, Schectman JM, Siadaty MS, Philbrick JT. D-dimer testing for deep venous thrombosis: a metaanalysis. Clin Chem 2004;50:1136-1147
23. Keeling DM, Mackie IJ, Moody A, Watson HG. The diagnosis of deep vein thrombosis in symptomatic outpatients and the potential for clinical assessment and D-dimer assays to reduce the need for diagnostic imaging. Br J Haematol 2004;124:15-25
24. Justice AC, Covinsky KE, Berlin JA. Assessing the generalizability of prognostic information. Ann Intern Med 1999;130:515-524
25. Moons KG, Biesheuvel CJ, Grobbee DE. Test research versus diagnostic research. Clin Chem 2004;50:473-476
26. Stein PD, Hull RD, Patel KC, et al. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review. Ann intern Med 2004;140:589-602
27. Oudega R, Toll DB, Bulte RJ, Hoes AW, Moons KGM. Different cut-off values for two D-dimer assays to exclude deep venous thrombosis in primary care. Thromb Haemost 2006;95:744-746
28. Michiels JJ, Kasbergen H, Oudega R, et al. Exclusion and diagnosis of deep vein thrombosis in outpatients by sequential noninvasive tools. Int Angiol 2002;21:9-19
29. Fancher TL, White RH, Kravitz RL. Combined use of rapid D-dimer testing and estimation of clinical probability in the diagnosis of deep vein thrombosis: systematic review. BMJ 2004;329:821
30. Wells PS, Owen C, Doucette S, Fergusson D, Tran H. Does this patient have deep vein thrombosis? JAMA 2006;295:199-207
31. Tamariz LJ, Eng I, Segal JB, et al. Usefulness ot clinical prediction rules for the diagnosis of venous thromboembolism: a systematic review. Am J Med 2004;117:676-684
32. Oudega R, Hoes AW, Moons KGM. Wells rule does not adequately rule out deep vein thrombosis in primary care, Ann Intern Med 2005;143:100-107
33. Oudega R, Moons KGM, Hoes AW. Limited value of pauent history and physical examination in diagnosing deep vein thrombosis in primary care. Fam Pract 2005;22:86-91
34. Laupacis A, Sekar N, Stiell IG. Clinical prediction rules. A review and suggested modifications of methodological standards. JAMA 1997;277:488-494
35. Wasson JH, Sox HC, Neff RK, Goldman L. Clinical prediction rules. Applications and methodological standards. N Engl J Med 1985;313:793-799
36. Moons KGM, Grobbee DE. Diagnostic studies as multivariable, prediction research. J Epidemiol Community Health 2002;56:337-338