The diagnosis of deep vein thrombosis in symptomatic outpatients and the potential for clinical assessment and D-dimer assays to reduce the need for diagnostic imaging

British Journal of Haematology

Volumn 124, Issue 1, 2004, Pages 15-25

  Keeling, David M ^a,b   Mackie, Ian J ^a,c   Moody, Alan ^a,d   Watson, Henry G ^a,e  

^a BCSH Secretary   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d QUEEN S MEDICAL CENTRE   (United Kingdom)

^e ABERDEEN ROYAL INFIRMARY   (United Kingdom)

Author keywords

D dimer; Deep vein thrombosis; Diagnosis

Indexed keywords

D DIMER; FIBRIN; FIBRINOGEN; HEPARIN; PLASMIN;

ARTIFICIAL EMBOLISM; DEEP VEIN THROMBOSIS; DIAGNOSTIC IMAGING; DISEASE ASSOCIATION; ECHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FATALITY; HUMAN; LEG COMPRESSION; MEDLINE; OUTPATIENT; PHLEBOGRAPHY; POSTTHROMBOSIS SYNDROME; PRACTICE GUIDELINE; PRIORITY JOURNAL; RECURRENT DISEASE; REVIEW; RISK FACTOR; SYMPTOM; THROMBOGENESIS;

ANTIBODIES, MONOCLONAL; DECISION MAKING; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; IMMUNOASSAY; VENOUS THROMBOSIS;

EID: 0347694796     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04723.x     Document Type: Review

References (61)

1. Agnelli, G., Cosmi, B., Radicchia, S., Veschi, F., Boschetti, E., Lupattelli, L., Rinonapoli, E. & Nenci, G.G. (1993) Features of thrombi and diagnostic accuracy of impedance plethysmography in symptomatic and asymptomatic deep vein thrombosis. Thrombosis and Haemostasis, 70, 266-269.
2. Anderson, F.J., Wheeler, H., Goldberg, R., Hosmer, D., Patwardhan, N., Jovanovic, B., Forcier, A. & Dalen, J. (1991) A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Archives of Internal Medicine, 151, 933-938.
3. Atri, M., Herba, M. J., Reinhold, C., Leclerc, J., Ye, S., Illescas, F.F. & Bret, P.M. (1996) Accuracy of sonography in the evaluation of calf deep vein thrombosis in both postoperative surveillance and symptomatic patients. AJR American Journal of Roentgenology, 166, 1361-1367.
4. Barrellier, M.T., Somon, T., Speckel, D., Fournier, L. & Denizet, D. (1992) Duplex ultrasonography in the diagnosis of deep vein thrombosis of the legs. Agreement between two operators. Journal des Maladies Vasculaires, 17, 196-201.
5. Bates, S.M., Grand'Maison, A., Johnston, M., Naguit, I., Kovacs, M.J. & Ginsberg, J.S. (2001) A latex D-dimer reliably excludes venous thromboembolism. Archives of Internal Medicine, 161, 447-453.
6. Belcaro, G. (1992) Evaluation of recurrent deep venous thrombosis using colour duplex scanning - comparison with venography. Journal for Vascular Diseases, 21, 22-26.
7. Bernardi, E., Prandoni, P., Lensing, A.W., Agnelli, G., Guazzaloca, G., Scannapieco, G., Piovella, F., Verlato, F., Tomasi, C., Moia, M., Scarano, L. & Girolami, A. (1998) D-dimer testing as an adjunct to ultrasonography in patients with clinically suspected deep vein thrombosis: prospective cohort study. The Multicentre Italian D-dimer Ultrasound Study Investigators Group. British Medical Journal, 317, 1037-1040.
8. Blaivas, M., Lambert, M.J., Harwood, R.A., Wood, J.P. & Konicki, J. (2000) Lower-extremity Doppler for deep venous thrombosis - can emergency physicians be accurate and fast? Academic Emergency Medicine, 7, 120-126.
9. Borg, J.Y., Levesque, H., Cailleux, N., Franc, C., Hellot, M.F. & Courtois, H. (1997) Rapid quantitative D-dimer assay and clinical evaluation for the diagnosis of clinically suspected deep vein thrombosis. Thrombosis and Haemostasis, 77, 602-603.
10. Bounameaux, H., de Moerloose, P., Perrier, A. & Miron, M.J. (1997) D-dimer testing in suspected venous thromboembolism: an update. Quarterly Journal of Medicine, 90, 437-442.
11. Brandjes, D.P., Buller, H.R., Heijboer, H., Huisman, M.V., de Rijk, M., Jagt, H. & ten Cate, J.W. (1997) Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis. Lancet, 349, 759-762.
12. Coel, M.N. (1980) Adequacy of lower limb venous opacification: comparison of supine and upright phlebography. AJR American Journal of Roentgenology, 134, 163-165.
13. Cogo, A., Lensing, A.W., Prandoni, P. & Hirsh, J. (1993) Distribution of thrombosis in patients with symptomatic deep vein thrombosis. Implications for simplifying the diagnostic process with compression ultrasound. Archives of Internal Medicine, 153, 2777-2780.
14. Cogo, A., Lensing, A.W., Wells, P., Prandoni, P. & Buller, H.R. (1995) Noninvasive objective tests for the diagnosis of clinically suspected deep-vein thrombosis. Haemostasis, 25, 27-39.
15. Cogo, A., Lensing, A.W., Koopman, M.M., Piovella, F., Siragusa, S., Wells, P.S., Villalta, S., Buller, H.R., Turpie, A.G. & Prandoni, P. (1998) Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study. British Medical Journal, 316, 17-20.
16. Coon, W., Willis, P.D. & Keller, J. (1973) Venous thromboembolism and other venous disease in the Tecumseh community health study. Circulation, 48, 839-846.
17. Couson, F., Bounameaux, C., Didier, D., Geiser, D., Meyerovitz, M.F., Schmitt, H.E., Schneider, P.A. & Bounameaux, H. (1993) Influence of variability of interpretation of contrast venography for screening of postoperative deep venous thrombosis on the results of a thromboprophylactic study. Thrombosis and Haemostasis, 70, 573-575.
18. D'Angelo, A., D'Alessandro, G., Tomassini, L., Pittet, J.L., Dupuy, G. & Crippa, L. (1996) Evaluation of a new rapid quantitative D-dimer assay in patients with clinically suspected deep vein thrombosis. Thrombosis and Haemostasis, 75, 412-416.
19. Elias, A., Le Corff, G., Bouvier, J.L., Benichou, M. & Serradimigni, A. (1987) Value of real time B mode ultrasound imaging in the diagnosis of deep vein thrombosis of the lower limbs. International Angiology, 6, 175-182.
20. Fraser, D.G., Moody, A.R., Morgan, P.S., Martel, A.L. & Davidson, I. (2002) Diagnosis of lower-limb deep venous thrombosis: a prospective blinded study of magnetic resonance direct thrombus imaging. Annals of Internal Medicine, 136, 89-98.
21. Gaffney, P. (1987) Fibrinolysis. In: Haemostasis and Thrombosis (ed. by A.L. Bloom & D.P. Thomas), pp. 223-244. Churchill Livingstone, Edinburgh.
22. Gaffney, P.J., Brasher, M., Lord, K., Strachan, C.J., Wilkinson, A.R., Kakkar, V.V. & Scully, M.F. (1976) Fibrin subunits in venous and arterial thromboembolism. Cardiovascular Research, 10, 421-426.
23. Gardiner, C., Pennaneach, H.C., Mackie, I.J., Machin, S.J., Walford, C. & Abe, G. (2002) Evaluation of Ten D-dimer Kits. Medical Devices Agency, London (HMSO, ISBN 1 84182 600 6).
24. van der Graaf, F., van den Borne, H., van der Kolk, M., de Wild, P.J., Janssen, G.W. & van Uum, S.H. (2000) Exclusion of deep venous thrombosis with D-dimer testing - comparison of 13 D-dimer methods in 99 outpatients suspected of deep venous thrombosis using venography as reference standard. Thrombosis and Haemostasis, 83, 191-198.
25. Hansson, P., Welin, L., Tibblin, G. & Eriksson, H. (1997) Deep vein thrombosis and pulmonary embolism in the general population. The Study of Men Born in 1913. Archives of Internal Medicine, 157, 1665-1670.
26. Hantgan, R.R., Francis, C.W. & Marder, V.J. (1994) Fibrinogen structure and physiology. In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice (ed. by R.W. Colman, J. Hirsh, V.J. Marder & E.W. Salzman), pp. 277-300. JB Lippincott Co., Philadelphia.
27. Hirsh, J. & Lee, A.Y. (2002) How we diagnose and treat deep vein thrombosis. Blood, 99, 3102-3110.
28. Illescas, F.F., Lerclerc, J., Rosenthall, L., Wolfson, C., Rush, C., Herba, M.J. & Arzoumanian, A. (1990) Interobserver variability in the interpretation of contrast venography, technetium-99m red blood cell venography and impedance plethysmography for deep vein thrombosis. Canadian Association of Radiologists Journal, 41, 264-269.
29. Janssen, M.C., Heebels, A.E., de Metz, M., Verbruggen, H., Wollersheim, H., Janssen, S., Schuurmans, M.M. & Novakova, I.R. (1997a) Reliability of five rapid D-dimer assays compared to ELISA in the exclusion of deep venous thrombosis. Thrombosis and Haemostasis, 77, 262-266.
30. Janssen, M.C., Verbruggen, H., Wollersheim, H., Hoogkamer, B., van Langen, H. & Novakova, I.R. (1997b) D-dimer determination to assess regression of deep venous thrombosis. Thrombosis and Haemostasis, 78, 799-802.
31. Kahn, S.R., Joseph, L., Grover, S.A. & Leclerc, J.R. (2001) A randomized management study of impedance plethysmography vs. contrast venography in patients with a first episode of clinically suspected deep vein thrombosis. Thrombosis Research, 102, 15-24.
32. Kahn, S.R., Macdonald, S., Miller, N. & Obrand, D. (2002) The natural history of untreated isolated calf muscle vein thrombosis: rate, timing and predictors of extension. Blood, 100, (abstract no. 78) [(www document) URI http://www.abstracts-on-line.com/abstracts/ hemphiladelphia02].
33. Kakkar, V.V., Howe, C.T., Flanc, C. & Clarke, M.B. (1969) Natural history of postoperative deep-vein thrombosis. Lancet, 2, 230-232.
34. Kearon, C., Julian, J.A., Newman, T.E. & Ginsberg, J.S. (1998) Non-invasive diagnosis of deep venous thrombosis. McMaster Diagnostic Imaging Practice Guidelines Initiative. Annals of Internal Medicine, 128, 663-677.
35. Lagerstedt, C.I., Olsson, C.G., Fagher, B.O., Oqvist, B.W. & Albrechtsson, U. (1985) Need for long-term anticoagulant treatment in symptomatic calf-vein thrombosis. Lancet, 2, 515-518.
36. Lensing, A.W., Prandoni, P., Brandjes, D., Huisman, P.M., Vigo, M., Tomasella, G., Krekt, J., Wouter Ten Cate, J., Huisman, M.V. & Buller, H.R. (1989) Detection of deep-vein thrombosis by real-time B-mode ultrasonography. New England Journal of Medicine, 320, 342-345.
37. Line, B.R. (2001) Pathophysiology and diagnosis of deep venous thrombosis. Seminars in Nuclear Medicine, 31, 90-101.
38. McLachlan, M.S., Thomson, J.G., Taylor, D.W., Kelly, M.E. & Sackett, D.L. (1979) Observer variation in the interpretation of lower limb venograms. AJR American Journal of Roentgenology, 132, 227-229.
39. Mosesson, M.W. (1995) Terminology for macromolecular derivatives of crosslinked fibrin. On behalf of the Subcommittee on Fibrinogen of the Scientific and Standardization Committee of the ISTH. Thrombosis and Haemostasis, 73, 725-726.
40. Nieuwenhuizen, W. (1997) A reference material for harmonisation of D-dimer assays. Fibrinogen Subcommittee of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis. Thrombosis and Haemostasis, 11, 1031-1033.
41. Nieuwenhuizen, W. & Bos, R. (1999) Soluble fibrin and degradation products of fibrinogen (FgDP), fibrin (FbDP; D-dimer) and total of FgDP and FbDP (TDP). In: Laboratory Techniques in Thrombosis - A Manual (ed. by J. Jespersen, R.M. Bertina & F. Haverkate), pp. 275-283. Kluwer Academic Publishers, The Netherlands.
42. Nordstrom, M., Lindblad, B., Bergqvist, D. & Kjellstrom, T. (1992) A prospective study of the incidence of deep-vein thrombosis within a defined urban population. Journal of Internal Medicine, 232, 155-160.
43. O'Leary, D.H., Kane, R.A. & Chase, B.M. (1988) A prospective study of the efficacy of B-scan sonography in the detection of deep venous thrombosis in the lower extremities. Journal of Clinical Ultrasound, 16, 1-8.
44. Perrier, A., Desmarais, S., Miron, M.J., de Moerloose, P., Lepage, R., Slosman, D., Didier, D., Unger, P.F., Patenaude, J.V. & Bounameaux, H. (1999) Non-invasive diagnosis of venous thromboembolism in outpatients. Lancet, 353, 190-195.
45. Philbrick, J.T. & Becker, D.M. (1988) Calf deep venous thrombosis. A wolf in sheep's clothing? Archives of Internal Medicine, 148, 2131-2138.
46. Prandoni, P., Cogo, A., Bernardi, E., Villalta, S., Polistena, P., Simioni, P., Noventa, F., Benedetti, L. & Girolami, A. (1993) A simple ultrasound approach for detection of recurrent proximal-vein thrombosis. Circulation, 88, 1730-1735.
47. Prandoni, P., Lensing, A., Cogo, A., Cuppini, S., Villalta, S., Carta, M., Cattelan, A., Polistena, P., Bernardi, E. & Prins, M. (1996) The long-term clinical course of acute deep venous thrombosis [see comments]. Annals of Internal Medicine, 125, 1-7.
48. Prandoni, P., Villalta, S., Bagatella, P., Rossi, L., Marchiori, A., Piccioli, A., Bernardi, E., Girolami, B., Simioni, P. & Girolami, A. (1997) The clinical course of deep-vein thrombosis. Prospective long-term follow-up of 528 symptomatic patients. Haematologica, 82, 423-428.
49. Prandoni, P., Lensing, A., Prins, M., Bagatella, P., Scudeller, A. & Girolami, A. (1999) Which is the outcome of the post-thrombotic syndrome?. Thrombosis and Haemostasis, 82, 1358 (letter).
50. Prandoni, P., Lensing, A.W., Piccioli, A., Bernardi, E., Simioni, P., Girolami, B., Marchiori, A., Sabbion, P., Prins, M.H., Noventa, F. & Girolami, A. (2002) Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood, 100, 3484-3488.
51. Rabinov, K. & Paulin, S. (1972) Roentgen diagnosis of venous thrombosis in the leg. Archives of Surgery, 104, 134-144.
52. Redman, H.C. (1988) Deep venous thrombosis: is contrast venography still the diagnostic "gold standard"? Radiology, 168, 277-278.
53. Rosch, J., Dotter, C.T., Seaman, A.J., Porter, J.M. & Common, H.H. (1976) Healing of deep venous thrombosis: venographic findings in a randomized study comparing streptokinase and heparin. AJR American Journal of Roentgenology, 127, 553-558.
54. Sie, P., Cadroy, Y., Elias, A., Boccalon, H. & Boneu, B. (1994) D-dimer levels in patients with long-term antecedents of deep venous thrombosis. Thrombosis and Haemostasis, 72, 161-162.
55. Silverstein, M., Heit, J., Mohr, D., Petterson, T., O'Fallon, W. & Melton, L.R. (1998) Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Archives of Internal Medicine, 158, 585-593.
56. Speiser, W., Mallek, R., Koppensteiner, R., Stumpflen, A., Kapiotis, S., Minar, E., Ehringer, H. & Lechner, K. (1990) D-dimer and TAT measurement in patients with deep venous thrombosis: utility in diagnosis and judgement of anticoagulant treatment effectiveness. Thrombosis and Haemostasis, 64, 196-201.
57. Stricker, H., Marchetti, O., Haeberli, A. & Mombelli, G. (1999) Hemostatic activation under anticoagulant treatment: a comparison of unfractionated heparin vs. nadroparin in the treatment of proximal deep vein thrombosis. Thrombosis and Haemostasis, 82, 1227-1231.
58. Wells, P.S., Hirsh, J., Anderson, D.R., Lensing, A.W., Foster, G., Kearon, C., Weitz, J., D'Ovidio, R., Cogo, A. & Prandoni, P. (1995) Accuracy of clinical assessment of deep-vein thrombosis [see comments]. Lancet, 345, 1326-1330 [published erratum appears in Lancet 1995 Aug. 19;346(8973):516].
59. Wells, P.S., Anderson, D.R., Bormanis, J., Guy, F., Mitchell, M., Gray, L., Clement, C., Robinson, K.S. & Lewandowski, B. (1997) Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet, 350, 1795-1798.
60. White, R.H., McGahan, J.P., Daschbach, M.M. & Hartling, R.P. (1989) Diagnosis of deep-vein thrombosis using duplex ultrasound. Annals of Internal Medicine, 111, 297-304.
61. Wille-Jorgensen, P., Borris, L., Jorgensen, L.N., Hauch, O., Lassen, M.R., Nehen, A.M., Kjaer, L. & Jensen, R. (1992) Phlebography as the gold standard in thromboprophylactic studies? A multicenter interobserver variation study. Acta Radiologica, 33, 24-28.