Gastroprotective effect of pectin preparations against indomethacin-induced lesions in rats

International Journal of Pharmacology

Volumn 2, Issue 4, 2006, Pages 471-476

  Khotimchenko, M Y ^a   Zueva, E P ^b   Lopatina, K A ^b   Khotimchenko, Y S ^c   Shilova, N V ^b  

^a PACIFIC STATE MEDICAL UNIVERSITY   (Russian Federation)

^b INSTITUTE OF PHARMACOLOGY   (Russian Federation)

^c INSTITUTE OF MARINE BIOLOGY   (Russian Federation)

Author keywords

Dietary fiber; Gastric ulcer; Indomethacin; Pectin

Indexed keywords

CALCIUM DERIVATIVE; CALCIUM PECTATE; INDOMETACIN; PECTIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; MALE; NONHUMAN; PRIMARY PREVENTION; RAT; STOMACH MUCOSA INJURY; STOMACH PROTECTION; STOMACH ULCER;

EID: 33750334489     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2006.471.476     Document Type: Article

References (40)

1. Afanasyev, S.P., V.Y. Chirva, G.N. Kaceva, E.P. Kuhta and E.P. Panova, 1984. The modification of titrimetric methods of analysis of pectic substances. Khimia Prirodnykh Soedinenii, 4: 428-431 (In Russian).
2. American Dietetic Association, 1997. Position of the American Dietetic Association: Health implications of dietary fiber. J. Am. Diet. Assoc., 97: 1157-1159.
3. Anger, H. and G. Berth, 1986. Gel permeation chromatography and the Mark-Houwink relation for pectins with different degrees of esterification. Carbohydr. Res., 6: 193-202.
4. Bates, F., G. Buckley and R. Strettle, 1979. The action of salmon calcitonin on indomethacin-induced gastric ulceration in the rat. Br. J. Pharmacol., 67: 483-484.
5. Blumenkrantz, S. and G. Asboe-Haunsen, 1973. New method for quantitative determination of uronic acids. Anal. Biochem., 54: 484-489.
6. Chan, F.K. and WK. Leung, 2002. Peptic ulcer disease. Lancet, 360: 933-941.
7. Chan, F.K. and D.Y. Graham, 2004. Review article: Prevention of nonsteroidal anti-inflammatory drug gastrointestinal complications-review and recommendations based on risk assessment. Aliment. Pharmacol. Ther., 19: 1051-1061.
8. Del Valle, J., W.D. Chey and J.M. Scheiman, 2003. Acid peptic disorders. In: Textbook of Gastroenterology, 4th (Ed.), Eds. Yamada, T. D.H. Alpers and N. Kaplowitz. Philadelphia: Lippincott Williams and Wilkins, pp: 1321-1376.
9. Elliott, S.L., R.J. Ferris, A.S. Giraud, G.A. Cook, M.V. Skeljo and N.D. Yeomans, 1996. Indomethacin damage to rat gastric mucosa is markedly dependent on luminal pH. Clin. Exp. Pharmacol. Physiol., 23: 432-434.
10. Ferrucci, F., E. Zucca, C. Croci, V. Di Fabio and E. Ferro, 2003. Treatment of gastric ulceration in 10 standardbred racehorses with a pectin-lecithin complex. Vet. Res., 152: 679-681.
11. García Rodríges, L.A., S. Hernandez-Díaz and F.L. De Abajo, 2001. Association between aspirin and upper gastrointestinal complications: Systematic review of epidemiologic studies. Br. J. Clin. Pharmacol., 52: 563-571.
12. García Rodríges, L.A. and S. Hernandez-Díaz, 2004. Risk of uncomplicated peptic ulcer among users of aspirin and nonaspirin nonsteroidal anti-inflammatory drugs. Am. J. Epidemiol., 159: 23-31.
13. García Rodríges, L.A. and S. Hernandez-Díaz, 2001. Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs. Epidemiology, 12: 570-576
14. Gonzalez, M., C. Rivas, B. Caride, M.A. Lamas and M.C. Taboada, 1998. Effect of orange and apple pectin on cholesterol concentration in serum, liver and faeces. J. Physiol. Biochem., 54: 99-104.
15. Hawkey, C.J., J.A. Karrasch, L. Szczepanski, D.G. Walker, A. Barkun, A.J. Swannell and N.D. Yeomans, 1998. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. N. Eng. J. Med., 338: 727-734.
16. Hawkey, C.J., 2000. Nonsteroidal anti-inflammatory drug gastropathy. Gastroenterology., 119: 521-535.
17. Henry, D., L.L.-Y. Lim and L.A. García Rodríges, 1996. Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: Results of a collaborative meta-analysis. B.M.J., 312: 1563-1566.
18. Hernandez-Díaz, S. and L.A. García Rodríges, 2000. Overview of epidemiological studies published in the nineties on the association between non-steroidal anti-inflammatory drugs and upper gastrointestinal bleed/perforation. Arch. Intern. Med., 160: 2093-2099.
19. Hudson, N., A.S. Taha and R.I. Russell, 1997. Famotidine for healing and maintenance in nonsteroidal anti-inflammatory drug-associated gastroduodenal ulceration. Gastroenterology, 112: 1817-1822.
20. Kapui, Z., K. Boer, I. Rozsa, G.Y. Blasko and I. Hermeez, 1993. Investigations of indomethacin-induced gastric ulcer in rats. Arzneim-Forsch/Drug Res., 43: 767-771.
21. Khotimchenko, Y.S., E.A. Kolenchenko, M.Y. Khotimchenko and V.V. Kovalev, 2004. Healing and preventing effects of low-esterified pectin on liver injury induced by carbon tetrachloride in rats. Oriental Pharm. Exp. Med., 4: 28-36.
22. Lai, K.C., S.K. Lam, K.M. Chu, B.C.Y. Wong and W.M. Hui et al., 2002. Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N. Eng. J. Med., 346: 2033-2038.
23. Langman, M.J.S., J. Weil and P. Wainwright, 1994. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet, 343: 1075-1078.
24. Levine, L., 2001. Stimulated release of arachidonic acid from rat liver cells by celecoxib and indomethacin. Prostaglandins Leukot. Essent. Fatty Acids, 65: 31-35.
25. Lim, C.H. and R.V. Heatley, 2005. Prospective study of acute gastrointestinal bleeding attributable to anti-inflammatory drug ingestion in the Yorkshire region of the United Kingdom. Postgrad. Med. J., 81: 252-254.
26. Micklewright, R., S. Lane and W. Linley, 2003. Review article: NSAIDs, gastroprotection and cyclooxygenase-II-selective inhibitors. Aliment. Pharmacol. Ther., 17: 321-332.
27. Patel, M. R., V.G. DeMarco, M. Clare-Salzler, Y.Y. Li and J. Neu, 2002. Indomethacin, Dexamethasone and Intestinal Damage in Infant Rats. J. Pediatr. Gastroenterol. Nutr., 35: 154-161.
28. Reeves, J.J. and R. Stables, 1985. Effects of indomethacin, piroxicam and selected prostanoids on gastric acid secretion by the rat isolated gastric mucosa. Br. J. Pharmacol., 86: 677-684.
29. Rifat-uz-Zaman, M.S., Akhtar and M.S. Khan, 2004. Preliminary evaluation of Anethum graveolens fruit in indomethacin-ulcer induced rats. J. Biol. Sci., 4: 151-156.
30. Rifat-uz-Zaman, M.S. Akhtar and M.S. Khan, 2006. Anti-ulcerogenic screening of Cichorium intybus L. leaf in indomethacin treated rats. Intl. J. Pharmacol., 2: 166-170.
31. Ryan-Harshman, M. and W. Aldoori, 2004. How diet and lifestyle affect duodenal ulcers. Review of the evidence. Can. Fam. Physician, 50: 727-732.
32. Schols, H.A. and A.G.J. Voragen, 1996. Complex pectins: Structure elucidation using enzymes, In: Pectins and pectinases. Eds. Visser, J. and A.G.J. Voragen, Elsevier Science. Amsterdam, The Netherlands, pp: 3-19.
33. Silverstein, F.E., D.Y. Graham and J.R. Senior, 1995. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: A randomized, double-blind, placebo-controlled trial. Ann. Intl. Med., 123: 241-249.
34. +-ATPase by the seleno-organic compound, ebselen. Arzneim Forsch/Drug Res., 44: 51-54.
35. Thakur, B.R., R.K. Singh and A.K. Handa, 1997. Chemistry and uses of pectin. A review. Crit. Rev. Food. Sci. Nutr., 37: 47-73.
36. Trommer, H. and R.H. Neubert, 2005. The examination of polysaccharides as potential antioxidative compounds for topical administration using a lipid model system. Intl. J. Pharm., 298: 153-163.
37. Waterhouse, E.T., C. Washington and N. Washington, 2000. An investigation into the efficacy of the pectin based anti-reflux formulation-Aflurax. Intl. J. Pharm., 209: 79-85.
38. Wolfe, M.M., D.R. Lichtenstein and G. Singh, 1999. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N. Eng. J. Med., 340: 1888-1899.
39. Yeomans, N.D., Z. Tulassay and L. Juhasz, 1998. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal anti-inflammatory drugs. N. Eng. J. Med., 338: 719-726.
40. Yoshikawa, T., Y. Naito, S. Nakamura and T. Kaneko, 1993. Effect of rebamipide on lipid peroxidation and gastric mucosal injury induced by indomethacin in rats. Arzneim-Forsch/Drug Res., 43: 1327-1330.