Anti-ulcerogenic screening of Cichorium intybus L. leaf in indomethacin treated rats

International Journal of Pharmacology

Volumn 2, Issue 2, 2006, Pages 166-170

  Rifat uz Zaman, ^a   Akhtar, Muhammad Shoaib ^b   Khan, Muhammad Shafiq ^a  

^a THE ISLAMIA UNIVERSITY OF BAHAWALPUR   (Pakistan)

^b UNIVERSITY OF AGRICULTURE   (Pakistan)

Author keywords

Acid buffering; Anti secretory; Anti ulcer; Cochorium intybus; Indomethacin; Ulcer index

Indexed keywords

ANTIULCER AGENT; BUFFER; CHICORY AQUEOUS EXTRACT; CHICORY ETHANOL EXTRACT; CHICORY EXTRACT; HERBACEOUS AGENT; INDOMETACIN; PLANT EXTRACT; STOMACH SECRETION INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHICORY; CONTROLLED STUDY; DOSE RESPONSE; IN VITRO STUDY; LIPID PEROXIDATION; MALE; NONHUMAN; PLANT LEAF; RAT; RAT STRAIN; STOMACH JUICE; STOMACH MUCOSA; STOMACH PH; STOMACH PROTECTION; STOMACH SECRETION; STOMACH ULCER; TREATMENT OUTCOME;

EID: 33646170880     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2006.166.170     Document Type: Article

References (34)

1. Aktay, G., D. Deliorman, E. Ergun, F. Ergun, E. Yesilada and C. Cevik, 2000. Hepatoprotective effects of Turkish folk remedies on experimental liver injury. J. Ethnopharmacol., 73: 121-129.
2. Amirghofran, Z., M. Azadbakht and M.H. Karimi, 2000. Evaluation of the immunomodulatory effects of five herbal plants. J. Ethnopharmacol., 72: 167-172.
3. Ahmed, B., T.A. Al-Howiriny and A.B. Siddiqui, 2003. Anti-hepatotoxic activity of seeds of Cichorium intybus. J. Ethnopharmacol., 87: 237-240.
4. Bais, H.P., G. Sudha and G.A. Ravishankar, 1999. Putrescine influences growth and production of coumarins in hairy root cultures of Witloof chicory (Cichorium intybus L. cv. Lucknow Local). J. Plant Growth Regul., 18: 159-165.
5. Du, H., S. Yuan and P. Jiang, 1998. Chemical constituents of Cichorium intybus L. Zhongguo Zhong Yao Za Zhi, 23: 682-683, 704.
6. El, S.N. and S. Karakaya, 2004. Radical scavenging and iron-chelating activities of some greens used as traditional dishes in Mediterranean diet. Intl. J. Food Sci. Nutr., 55: 67-74.
7. Gurbuz, I., O. Ustun, E. Yesilada, E. Sezik and N. Akyurek, 2002. In vivo gastroprotective effects of five Turkish folk remedies against ethanol-induced lesions. J. Ethnopharmacol., 83: 241-244.
8. Hirohashi, M., K. Takasuna, Y. Kasi, C. Usui, K. Tamura and H. Kojima, 1993. General pharmacological profile of the new anti-ulcer drug 3- [2-(3, 4-Dimethoxyphenyl) ethyl] carbamoyl] amino-N-methylbenzamide. Arzneim-Forsch/Drug Res., 43: 569-577.
9. Hebette, C.L., J.A. Delcour, M.H. Koch, K. Booten, R. Kleppinger, N. Mischenko and H. Reynaers, 1998. Complex melting of semi-crystalline chicory (Cichorium intybus L.) root inulin. Carbohydr. Res., 310: 65-75.
10. Hazra, B., R. Sarkar, S. Bhattacharyya and P. Roy, 2002. Tumour inhibitory activity of chicory root extract against Ehrlich ascites carcinoma in mice. Fitoterapia, 73: 730-733.
11. Ishizuka, Y., T. Kamisai and M. Sato, 1996. Anti-gastric acid secretary mechanism of 1, 6-Dihydro-2-[2-(2- methylpropoxy) anilino]-6-oxo-5-pyrimidinecarboxylic acid. Arzneim-Forsch/Drug Res., 46: 919-922.
12. Kirtikar, R.K. and D.B. Basu, 1987. Indian Medicinal Plants, Vol. III. 2nd Edn., International Book Distributors, 9/B, Rajpur Road, 1st floor, Dehradum 28001, India 1433-1434.
13. Kapui, Z., K. Boer, I. Rozsa, G.Y. Blasko and I. Hermeez, 1993. Investigations of Indomethacin-induced gastric ulcer in rats. Arzneim-Forsch/Drug Res., 43: 767-771.
14. Kalantari. H. and I.M. Chang, 1997. Liver protection from medicinal plants in mice. Korear J. Toxicol., 13: 193-196.
15. Kim, M. and H.K. Shin, 1998. The water-soluble extract of chicory influences serum and liver lipid concentrations, cecal short-chain fatty acid concentrations and fecal lipid excretion in rats. J. Nutr., 128: 1731-1736.
16. Kisiel, W. and K. Zielinska, 2001. Guaianolides from Cichorium intybus and structure revision of Cichorium sesquiterpene lactones. Phytochemistry, 57: 523-527.
17. Kwiecien, S., T. Brzozowski, P.C. Konturek, S.J. Konturek, M. Pawlik, R. Pajdo, D. Drozdowicz, A. Ptak and E.G. Hahn, 2001. Effect of central and peripheral actions of histamine and its metabolite N-alpha methyl histamine on gastric secretion and acute gastric lesions. J. Physiol. Pharmacol., 52: 625-638.
18. Limami, M.A., L.Y. Sun, C. Douat, J. Helgeson and D. Tepfer, 1988. Natural genetic transformation by agrobacterium rhizogenes. Annual flowering in two biennials, Belgian endive and arrot. Plant Physiol., 118: 543-550.
19. Lee, K.T., J.I. Kim, H.J. Park, K.O. Yoo, Y.N. Han and K. Miyamoto, 2000. Differentiation-inducing effect of magnolialide, a 1 β-hydroxyeudesmanolide isolated from Cichorium intybus, on human leukemia cells. Biol. Pharm. Bull., 23: 1005-1007.
20. Levine, L., 2001. Stimulated release of arachidonic acid from rat liver cells by celecoxib and indomethacin. Prostaglandins Leukot Essent Fatty Acids, 65: 31-35.
21. Moon, B.Y., K. Sa-Ouk and P.C. Boon, 2000. Enzyme-Like Activity of Glycated Cross-Linked Proteins in Free Radical Generation. Ann. New York Acad. Sci., 899: 168-181.
22. Molan, A.L., A.J. Duncan, T.N. Barry and W.C. McNabb, 2003. Effects of condensed tannins and crude sesquiterpene lactones extracted from chicory on the motility of larvae of deer lungworm and gastrointestinal nematodes. Parasitol. Intl., 52: 209-218.
23. Papetti, A., M. Daglia and G. Gazzani, 2002. Anti- and pro-oxidant activity of water-soluble compounds in Cichorium intybus var. silvestre (Treviso red chicory). J. Pharm. Biomed. Anal., 30: 939-944.
24. Pieroni, A., V. Janiak, C.M. Durr, S. Ludeke, E. Trachsel and M. Heinrich, 2002. In vitro antioxidant activity of non-cultivated vegetables of ethnic Albanians in southern Italy. Phytother. Res., 16: 467-473.
25. Rees, S. and J. Harborne, 1984. Flavonoids and other phenolics of cichorium and related members of the lactuceae (Compositae). Bot. J. Linn. Soc., 89: 313-319.
26. Reeves, J.J. and R. Stables, 1985. Effects of indomethacin, piroxicam and selected prostanoids on gastric acid secretion by the rat isolated gastric mucosa. Br. J. Pharmacol., 86: 677-684.
27. Roberfroid, M.B., 2000. Chicory fructooligosaccharides and the gastrointestinal tract. Nutrition, 16: 677-679.
28. Rifat-uz-Zaman, M.S. Akhtar and M.S. Khan, 2004. Preliminary evaluation of Anethum graveolens fruit in indomethacin-ulcer induced rats. J. Biol. Sci., 4: 151-156.
29. Rifat-uz-Zaman, M.S. Akhtar and M.S. Khan, 2005. Protective effects of Polygonum viviparum L. root and its extracts against lipid-peroxidation induced by Indomethacin in Rats. Intl. J Pharmacol., 1: 224-228.
30. Sanders, D.H., 1990. Statistics. A Fresh Approach, 4th Edn., Auckland: McGraw-Hill Book Company.
31. Smith, W.L. and L.J. Marnett, 1991. Prostaglandin endoperoxide synthase: structure and catalysis. Biochim. Biophys. Acta, 1083: 1-17.
32. +-ATPase by the Seleno-organic Compound, Ebselen. Arzneium-Forsch/Drug Res., 44: 51-54.
33. Takeuchi, K., S. Kato, Y. Ogawa, K. Kanatsu and M. Umeda, 2001. Role of endogenous prostacyclin in gastric ulcerogenic and healing responses-a study using IP-receptor knockout mice. J. Physiol. Paris, 95: 75-80.
34. Yoshikawa, T., Y. Naito, S. Nakamura, T. Kaneko, S. Iinuma and S. Takahashi et al., 1993. Effect of Rebamipide on lipid peroxidation and gastric mucosal injury induced by indomethacin in rats. Arzneim-Forsch/ Drug Res., 43: 1327-1330.