메뉴 건너뛰기




Volumn 3, Issue 2, 2006, Pages 53-58

Human genetic variability and HIV treatment response

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; ANTIVIRUS AGENT; ATAZANAVIR; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CYTOCHROME P450 2B6; EFAVIRENZ; INDINAVIR; TUMOR NECROSIS FACTOR ALPHA;

EID: 33750283266     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-006-0018-x     Document Type: Review
Times cited : (19)

References (50)
  • 1
    • 15844419153 scopus 로고    scopus 로고
    • Identification of a major co-receptor for primary isolates of HIV-1
    • Deng H, Liu R, Ellmeier W, et al.: Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996, 381:661-666.
    • (1996) Nature , vol.381 , pp. 661-666
    • Deng, H.1    Liu, R.2    Ellmeier, W.3
  • 2
    • 15844389650 scopus 로고    scopus 로고
    • HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    • Dragic T, Litwin V, Allaway GP, et al.: HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996, 381:667-673.
    • (1996) Nature , vol.381 , pp. 667-673
    • Dragic, T.1    Litwin, V.2    Allaway, G.P.3
  • 3
    • 0001633495 scopus 로고    scopus 로고
    • Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study
    • Dean M, Carrington M, Winkler C, et al.: Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 1996, 273:1856-1862.
    • (1996) Science , vol.273 , pp. 1856-1862
    • Dean, M.1    Carrington, M.2    Winkler, C.3
  • 4
    • 0038681023 scopus 로고    scopus 로고
    • Broad antiretroviral defense by human APOBEC3G through lethal editing of nascent reverse transcripts
    • Mangeat B, Turelli P, Caron G, et al.: Broad antiretroviral defense by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature 2003, 424:99-103.
    • (2003) Nature , vol.424 , pp. 99-103
    • Mangeat, B.1    Turelli, P.2    Caron, G.3
  • 5
    • 1542288934 scopus 로고    scopus 로고
    • The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys
    • Stremlau M, Owens CM, Perron MJ, et al.: The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature 2004, 427:848-853.
    • (2004) Nature , vol.427 , pp. 848-853
    • Stremlau, M.1    Owens, C.M.2    Perron, M.J.3
  • 6
    • 20044384693 scopus 로고    scopus 로고
    • AP-3 directs the intracellular trafficking of HIV-1 gag and plays a key role in particle assembly
    • Dong X, Li H, Derdowski A, et al.: AP-3 directs the intracellular trafficking of HIV-1 gag and plays a key role in particle assembly. Cell 2005, 120:663-674.
    • (2005) Cell , vol.120 , pp. 663-674
    • Dong, X.1    Li, H.2    Derdowski, A.3
  • 7
    • 0142155149 scopus 로고    scopus 로고
    • A multi-investigator/institutional DNA bank for AIDS-related human genetic studies: AACTG protocol A5128
    • Haas DW, Wilkinson GR, Kuritzkes DR, et al.: A multi-investigator/ institutional DNA bank for AIDS-related human genetic studies: AACTG protocol A5128. HIV Clinical Trials 2003, 4/5:287-300.
    • (2003) HIV Clinical Trials , vol.4-5 , pp. 287-300
    • Haas, D.W.1    Wilkinson, G.R.2    Kuritzkes, D.R.3
  • 8
    • 0034798191 scopus 로고    scopus 로고
    • Hypersensitivity related to abacavir in two members of a family
    • Peyrieere H, Nicolas J, Siffert M, et al.: Hypersensitivity related to abacavir in two members of a family. Ann Pharmacother 2001, 35:1291-1292.
    • (2001) Ann Pharmacother , vol.35 , pp. 1291-1292
    • Peyrieere, H.1    Nicolas, J.2    Siffert, M.3
  • 9
    • 0036246069 scopus 로고    scopus 로고
    • Risk factor analysis of hypersensitivity reactions to abacavir
    • Symonds W, Cutrell A, Edwards M, et al.: Risk factor analysis of hypersensitivity reactions to abacavir. Clin Ther 2002, 24:565-573.
    • (2002) Clin Ther , vol.24 , pp. 565-573
    • Symonds, W.1    Cutrell, A.2    Edwards, M.3
  • 10
    • 0037006623 scopus 로고    scopus 로고
    • Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    • Mallal S, Nolan D, Witt C, et al.: Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 2002, 359:727-732. This seminal report identified an underlying immunogenetic predisposition to abacavir hypersensitivity.
    • (2002) Lancet , vol.359 , pp. 727-732
    • Mallal, S.1    Nolan, D.2    Witt, C.3
  • 11
    • 0037197044 scopus 로고    scopus 로고
    • Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
    • Hetherington S, Hughes AR, Mosteller M, et al.: Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet 2002, 359:1121-1122.
    • (2002) Lancet , vol.359 , pp. 1121-1122
    • Hetherington, S.1    Hughes, A.R.2    Mosteller, M.3
  • 12
    • 12144287198 scopus 로고    scopus 로고
    • Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
    • Martin AM, Nolan D, Gaudieri S, et al.: Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Proc Natl Acad Sci U S A 2004, 101:4180-4185.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4180-4185
    • Martin, A.M.1    Nolan, D.2    Gaudieri, S.3
  • 13
    • 0032493441 scopus 로고    scopus 로고
    • Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
    • Beutler E, Gelbart T, Demina A: Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci USA 1998, 95:8170-8174.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8170-8174
    • Beutler, E.1    Gelbart, T.2    Demina, A.3
  • 14
    • 0035940414 scopus 로고    scopus 로고
    • Mechanism of indinavir-induced hyperbilirubinemia
    • Zucker SD, Qin X, Rouster SD, et al.: Mechanism of indinavir-induced hyperbilirubinemia. Proc Natl Acad Sci USA 2001, 98:12671-12676.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12671-12676
    • Zucker, S.D.1    Qin, X.2    Rouster, S.D.3
  • 15
    • 84255204998 scopus 로고    scopus 로고
    • Population pharmacodynamic assessment of atazanavir exposure, uridine diphosphate-glucuronosyl transferase (UGT) 1A1 genotype and safety in healthy subjects
    • [abstract 3051] Presented at the. Chicago, IL; December 16-19
    • O'Mara E, Randall D, Passarell J, et al.: Population pharmacodynamic assessment of atazanavir exposure, uridine diphosphate-glucuronosyl transferase (UGT) 1A1 genotype and safety in healthy subjects [abstract 3051]. Presented at the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL; December 16-19, 2001.
    • (2001) 41st Interscience Conference on Antimicrobial Agents and Chemotherapy
    • O'Mara, E.1    Randall, D.2    Passarell, J.3
  • 16
    • 0033576816 scopus 로고    scopus 로고
    • Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults
    • Study 006 Team
    • Staszewski S, Morales-Ramirez J, Tashima KT, et al.: Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team. New Engl J Med 1999, 341:1865-1873.
    • (1999) New Engl J Med , vol.341 , pp. 1865-1873
    • Staszewski, S.1    Morales-Ramirez, J.2    Tashima, K.T.3
  • 17
    • 0035875828 scopus 로고    scopus 로고
    • Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
    • Marzolini C, Telenti A, Decosterd LA, et al.: Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS 2001, 15:71-75.
    • (2001) AIDS , vol.15 , pp. 71-75
    • Marzolini, C.1    Telenti, A.2    Decosterd, L.A.3
  • 18
    • 0036847341 scopus 로고    scopus 로고
    • Population pharmacokinetic meta-analysis with efavirenz
    • Barrett IS, Joshi AS, Chai M, et al.: Population pharmacokinetic meta-analysis with efavirenz. Int J Clin Pharmacol Ther 2002, 40:507-519.
    • (2002) Int J Clin Pharmacol Ther , vol.40 , pp. 507-519
    • Barrett, I.S.1    Joshi, A.S.2    Chai, M.3
  • 19
    • 0037226529 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacody namics of efavirenz, nelfinavir, and indinavir: Adult AIDS Clinical Trial Group Study 398
    • Pfister M, Labbe L, Hammer SM, et al.: Population pharmacokinetics and pharmacody namics of efavirenz, nelfinavir, and indinavir: Adult AIDS Clinical Trial Group Study 398. Antimicrob Agents Chemother 2003, 47:130-137.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 130-137
    • Pfister, M.1    Labbe, L.2    Hammer, S.M.3
  • 20
    • 4544246769 scopus 로고    scopus 로고
    • Relationships between efavirenz pharmacokinetics, side effects, drug discontinuation, virologic response, and race: Results from ACTG A5095/A5097S
    • [abstract 132]. Paper presented at. San Francisco, CA; February 8-11
    • Ribaudo H, Clifford D, Gulick R, et al.: Relationships between efavirenz pharmacokinetics, side effects, drug discontinuation, virologic response, and race: results from ACTG A5095/A5097S [abstract 132]. Paper presented at 11th Conference on Retroviruses and Opportunistic Infections. San Francisco, CA; February 8-11, 2004.
    • (2004) 11th Conference on Retroviruses and Opportunistic Infections
    • Ribaudo, H.1    Clifford, D.2    Gulick, R.3
  • 21
    • 0038002981 scopus 로고    scopus 로고
    • The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: Implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
    • Ward BA, Gorski JC, Jones DR, et al.: The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol Exp Ther 2003, 306:287-300.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 287-300
    • Ward, B.A.1    Gorski, J.C.2    Jones, D.R.3
  • 22
    • 10744221053 scopus 로고    scopus 로고
    • Hepatic CYP2B6 expression: Gender and ethnic differences and relationship to CYP2B6 genotype and CAR expression
    • Lamba V, Lamba J, Yasuda K, et al.: Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR expression. J Pharmacol Exp Ther 2003, 3:906-922.
    • (2003) J Pharmacol Exp Ther , vol.3 , pp. 906-922
    • Lamba, V.1    Lamba, J.2    Yasuda, K.3
  • 23
    • 0034948077 scopus 로고    scopus 로고
    • Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver
    • Lang T, Klein K, Fischer J, et al.: Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics 2001, 11:399-415.
    • (2001) Pharmacogenetics , vol.11 , pp. 399-415
    • Lang, T.1    Klein, K.2    Fischer, J.3
  • 24
    • 0142188754 scopus 로고    scopus 로고
    • Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6
    • Kirchheiner J, Klein C, Meineke I, et al.: Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. Pharmacogenetics 2003, 13:619-626.
    • (2003) Pharmacogenetics , vol.13 , pp. 619-626
    • Kirchheiner, J.1    Klein, C.2    Meineke, I.3
  • 25
    • 19944428456 scopus 로고    scopus 로고
    • Pharmacogenetics of efavirenz and central nervous system side effects: An Adult AIDS Clinical Trials Group study
    • Haas DW, Ribaudo HJ, Kim RB, et al.: Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS 2004, 18:2391-2400. This seminal study established that a frequent CYP2B6 polymorphism is associated with increased plasma efavirenz exposure and increased central nervous system side effects. This polymorphism may help to explain previously reported racial differences in plasma efavirenz clearance.
    • (2004) AIDS , vol.18 , pp. 2391-2400
    • Haas, D.W.1    Ribaudo, H.J.2    Kim, R.B.3
  • 26
    • 27944460707 scopus 로고    scopus 로고
    • Pharmacogenetics of long-term responses to antiretroviral regimens containing efavirenz and/or nelfinavir: An Adult AIDS Clinical Trials Group study
    • Haas DW, Smeaton LM, Shafer RW, et al.: Pharmacogenetics of long-term responses to antiretroviral regimens containing efavirenz and/or nelfinavir: an Adult AIDS Clinical Trials Group study. J Infect Dis 2005, 192:1931-1942.
    • (2005) J Infect Dis , vol.192 , pp. 1931-1942
    • Haas, D.W.1    Smeaton, L.M.2    Shafer, R.W.3
  • 27
    • 31044456584 scopus 로고    scopus 로고
    • Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: An Adult AIDS Clinical Trials Group Study
    • Ribaudo HJ, Haas DW, Tierney C, et al.: Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study. Clin Infect Dis 2006, 42:401-407.
    • (2006) Clin Infect Dis , vol.42 , pp. 401-407
    • Ribaudo, H.J.1    Haas, D.W.2    Tierney, C.3
  • 28
    • 0033924871 scopus 로고    scopus 로고
    • Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection
    • Mallal SA, John M, Moore CB, et al.: Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection. AIDS 2000, 14:1309-1316.
    • (2000) AIDS , vol.14 , pp. 1309-1316
    • Mallal, S.A.1    John, M.2    Moore, C.B.3
  • 29
    • 0037161026 scopus 로고    scopus 로고
    • Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance
    • Bastard JP, Caron M, Vidal H, et al.: Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance. Lancet 2002, 359:1026-1031.
    • (2002) Lancet , vol.359 , pp. 1026-1031
    • Bastard, J.P.1    Caron, M.2    Vidal, H.3
  • 30
    • 0033073540 scopus 로고    scopus 로고
    • The role of TNF alpha in adipocyte metabolism
    • Sethi JK, Hotamisligil GS: The role of TNF alpha in adipocyte metabolism. Semin Cell Dev Biol 1999, 10:19-29.
    • (1999) Semin Cell Dev Biol , vol.10 , pp. 19-29
    • Sethi, J.K.1    Hotamisligil, G.S.2
  • 31
    • 0037131198 scopus 로고    scopus 로고
    • TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy
    • Maher B, Alfirevic A, Vilar FJ, et al.: TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. AIDS 2002, 16:2013-2018.
    • (2002) AIDS , vol.16 , pp. 2013-2018
    • Maher, B.1    Alfirevic, A.2    Vilar, F.J.3
  • 32
    • 0037415033 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha gene -238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy
    • Nolan D, Moore C, Castley A, et al.: Tumor necrosis factor-alpha gene -238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy. AIDS 2003, 17:121-123.
    • (2003) AIDS , vol.17 , pp. 121-123
    • Nolan, D.1    Moore, C.2    Castley, A.3
  • 33
    • 18744432281 scopus 로고    scopus 로고
    • HIV-1 protease inhibitors and the MDR1 multidrug transporter
    • Lee CG, Gottesman MM: HIV-1 protease inhibitors and the MDR1 multidrug transporter. J Clin Invest 1998, 101:287-288.
    • (1998) J Clin Invest , vol.101 , pp. 287-288
    • Lee, C.G.1    Gottesman, M.M.2
  • 34
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    • Kim RB, Fromm MF, Wandel C, et al.: The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 1998, 101:289-294.
    • (1998) J Clin Invest , vol.101 , pp. 289-294
    • Kim, R.B.1    Fromm, M.F.2    Wandel, C.3
  • 35
    • 0031788927 scopus 로고    scopus 로고
    • Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters
    • Srinivas RV, Middlemas D, Flynn P, Fridland A: Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters. Antimicrob Agents Chemo 1998, 42:3157-3162.
    • (1998) Antimicrob Agents Chemo , vol.42 , pp. 3157-3162
    • Srinivas, R.V.1    Middlemas, D.2    Flynn, P.3    Fridland, A.4
  • 36
    • 0032804327 scopus 로고    scopus 로고
    • Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor
    • Polli JW, Jarrett JL, Studenberg SD, et al.: Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor. Pharmaceutical Res 1999, 16:1206-1212.
    • (1999) Pharmaceutical Res , vol.16 , pp. 1206-1212
    • Polli, J.W.1    Jarrett, J.L.2    Studenberg, S.D.3
  • 37
    • 0033827147 scopus 로고    scopus 로고
    • The disposition of saquinavir in normal and P-glycoprotein deficient mice, rats, and in cultured cells
    • Washington CB, Wiltshire HR, Man M, et al.: The disposition of saquinavir in normal and P-glycoprotein deficient mice, rats, and in cultured cells. Drug Metabol Disp 2000, 28:1058-1062.
    • (2000) Drug Metabol Disp , vol.28 , pp. 1058-1062
    • Washington, C.B.1    Wiltshire, H.R.2    Man, M.3
  • 38
    • 1642523162 scopus 로고    scopus 로고
    • Polymorphisms in human MDR1 (P-glycoprotein): Recent advances and clinical relevance
    • Marzolini C, Paus E, Buclin T, Kim RB: Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther 2004, 75:13-33. This excellent review summarized the state of knowledge regarding MDR1 genetic variants and their potential clinical relevance.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 13-33
    • Marzolini, C.1    Paus, E.2    Buclin, T.3    Kim, R.B.4
  • 39
    • 0037022006 scopus 로고    scopus 로고
    • Response to anti-retroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: A pharmacogenetics study
    • Fellay J, Marzolini C, Meaden ER, et al.: Response to anti-retroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Lancet 2002, 359:30-36.
    • (2002) Lancet , vol.359 , pp. 30-36
    • Fellay, J.1    Marzolini, C.2    Meaden, E.R.3
  • 40
    • 0037462209 scopus 로고    scopus 로고
    • Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response
    • Brumme ZL, Dong WW, Chan KJ, et al: Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response. AIDS 2003, 17:201-208.
    • (2003) AIDS , vol.17 , pp. 201-208
    • Brumme, Z.L.1    Dong, W.W.2    Chan, K.J.3
  • 41
    • 0042127239 scopus 로고    scopus 로고
    • MDR1 C3435T genetic polymorphism does not influence the response to anti-retroviral therapy in drug-naive HIV-positive patients
    • Nasi M, Borghi V, Pinti M, et al.: MDR1 C3435T genetic polymorphism does not influence the response to anti-retroviral therapy in drug-naive HIV-positive patients. AIDS 2003, 17:1696-1698.
    • (2003) AIDS , vol.17 , pp. 1696-1698
    • Nasi, M.1    Borghi, V.2    Pinti, M.3
  • 42
    • 0242664934 scopus 로고    scopus 로고
    • MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: An adult AIDS Clinical Trials Group study
    • Haas DW, Wu H, Li H, et al.: MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study. J Acquir Immune Defic Syndr 2003, 34:295-298.
    • (2003) J Acquir Immune Defic Syndr , vol.34 , pp. 295-298
    • Haas, D.W.1    Wu, H.2    Li, H.3
  • 43
    • 20244364148 scopus 로고    scopus 로고
    • Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients
    • Rotger M, Colombo S, Furrer H, et al.: Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. Pharmacogenet Genomics 2005, 15:1-5.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 1-5
    • Rotger, M.1    Colombo, S.2    Furrer, H.3
  • 44
    • 3843102584 scopus 로고    scopus 로고
    • Alleles of the gene encoding IL-lalpha may predict control of plasma viraemia in HIV-1 patients on highly active antiretroviral therapy
    • Price P, James I, Fernandez S, French MA: Alleles of the gene encoding IL-lalpha may predict control of plasma viraemia in HIV-1 patients on highly active antiretroviral therapy. AIDS 2004, 18:1495-1501.
    • (2004) AIDS , vol.18 , pp. 1495-1501
    • Price, P.1    James, I.2    Fernandez, S.3    French, M.A.4
  • 45
    • 23044446936 scopus 로고    scopus 로고
    • Pharmacogenetics of nevirapine (NVP) and hepatotoxicity: An AACTG Collaborative study
    • Presented at the. Boston, MA; February 22-25
    • Haas DW, Bartlett JA, Andersen JA, et al.: Pharmacogenetics of nevirapine (NVP) and hepatotoxicity: an AACTG Collaborative study. Presented at the 12th Conference on Retroviruses and Opportunistic Infections. Boston, MA; February 22-25, 2005.
    • (2005) 12th Conference on Retroviruses and Opportunistic Infections
    • Haas, D.W.1    Bartlett, J.A.2    Andersen, J.A.3
  • 46
    • 33444456146 scopus 로고    scopus 로고
    • Genetic variation in drug transporter and metabolizing enzyme genes may be associated with non-nucleoside reverse transcriptase inhibitor (NNRTI) hepatotoxicity
    • Presented at the. Boston, MA February 22-25, 2005
    • Ritchie MD, Haas DW, Motsinger AA, et al.: Genetic variation in drug transporter and metabolizing enzyme genes may be associated with non-nucleoside reverse transcriptase inhibitor (NNRTI) hepatotoxicity. Presented at the 12th Conference on Retroviruses and Opportunistic Infections. Boston, MA 2005; February 22-25, 2005.
    • (2005) 12th Conference on Retroviruses and Opportunistic Infections
    • Ritchie, M.D.1    Haas, D.W.2    Motsinger, A.A.3
  • 47
    • 29144452191 scopus 로고    scopus 로고
    • Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: An adult AIDS clinical trials group study
    • Hulgan T, Haas DW, Haines JL, et al.: Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study. AIDS 2005, 19:1341-1349. This is the first study to suggest that interindividual differences in mitochondrial genetics may predispose to NRT1 toxicity.
    • (2005) AIDS , vol.19 , pp. 1341-1349
    • Hulgan, T.1    Haas, D.W.2    Haines, J.L.3
  • 48
    • 12144260460 scopus 로고    scopus 로고
    • Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts
    • Martin AM, Nolan D, James I, et al.: Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts. AIDS 2005, 19:97-99.
    • (2005) AIDS , vol.19 , pp. 97-99
    • Martin, A.M.1    Nolan, D.2    James, I.3
  • 49
    • 20244375708 scopus 로고    scopus 로고
    • Modeling the influence of APOC3, APOE, and TNF polymorphisms on the risk of antiretroviral therapy-associated lipid disorders
    • Tarr PE, Taffe P, Bleiber G, et al.: Modeling the influence of APOC3, APOE, and TNF polymorphisms on the risk of antiretroviral therapy-associated lipid disorders. J Infect Dis 2005, 191:1419-1426. This study, with Foulkes et al. [50•], highlights the complexity involved in attempting to discern an underlying genetic predisposition to drug-induced dyslipidemia.
    • (2005) J Infect Dis , vol.191 , pp. 1419-1426
    • Tarr, P.E.1    Taffe, P.2    Bleiber, G.3
  • 50
    • 33645329876 scopus 로고    scopus 로고
    • Associations among race/ethnicity, ApoC-III genotypes, and lipids in HIV-1-infected individuals on antiretroviral therapy
    • Foulkes AS, Wohl DA, Frank I, et al.: Associations among race/ethnicity, ApoC-III genotypes, and lipids in HIV-1-infected individuals on antiretroviral therapy. PLoS Med 2006, 3-e53:0001-011. This study, with Tarr et al. [49•], highlights the complexity involved in attempting to discern an underlying genetic predisposition to drug-induced dyslipidemia. This study, with Tarr et al. [49•], highlights the complexity involved in attempting to discern an underlying genetic predisposition to drug-induced dyslipidemia.
    • (2006) PLoS Med , vol.3 E53 , pp. 0001-0011
    • Foulkes, A.S.1    Wohl, D.A.2    Frank, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.