Effect of short-term sequential administration of nonsteroidal anti-inflammatory drugs on the stomach and proximal portion of the duodenum in healthy dogs

American Journal of Veterinary Research

Volumn 67, Issue 10, 2006, Pages 1794-1801

  Dowers, Kristy L ^a   Uhrig, Samantha R ^a   Mama, Khursheed R ^a   Gaynor, James S ^b   Hellyer, Peter W ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b Animal Anesthesia and Pain Management Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARPROFEN; CYCLOOXYGENASE 2 INHIBITOR; DERACOXIB; NONSTEROID ANTIINFLAMMATORY AGENT; SODIUM CHLORIDE; UNCLASSIFIED DRUG; VETERINARY DRUG;

ARTICLE; CARDIA; CONTROLLED STUDY; DISEASE EXACERBATION; DOG; DUODENUM INJURY; ESOPHAGUS INJURY; FEMALE; GASTRODUODENAL ULCER; GASTROINTESTINAL ENDOSCOPY; HISTOPATHOLOGY; NONHUMAN; RANDOMIZATION; SCORING SYSTEM; STOMACH ANTRUM; STOMACH FUNDUS; STOMACH LESION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARBAZOLES; CROSS-OVER STUDIES; DOG DISEASES; DOGS; DRUG ADMINISTRATION SCHEDULE; DUODENAL DISEASES; FEMALE; HEALTH; INJECTIONS, SUBCUTANEOUS; STOMACH; STOMACH DISEASES; SULFONAMIDES;

ANIMALIA; CANIS FAMILIARIS;

EID: 33750209766     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.67.10.1794     Document Type: Article

References (35)

1. Mathews KA. Nonsteroidal anti-inflammatory analgesics. Indications and contraindications for pain management in dogs and cats. Vet Clin North Am Small Anim Pract 2000;30:783-804.
2. Vane JR, Botting RM. New insights into mode of action of anti-inflammatory drugs. Inflamm Res 1990;44:1-10.
3. Pairet M, Englehardt G. Distinct isoforms (COX-1 and COX-2) of cyclooxygenase: possible physiological and therapeutic implications. Fundam Clin Pharmacol 1996;10:1-15.
4. Wilson JE, Chandrasekharan NV, Westeover KD, et al. Determination of expression of cyclooxygenase-1 and -2 isoenzymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res 2004;65:810-818.
5. Wallace JL. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 1997;112:1000-1016.
6. Hawkey CJ, Langman MJS. Non-steroidal anti-infammatory drugs: overall risks and management. Complementary roles for COX-2 inhibitors and proton pump inhibitors. Gut 2003;52:600-608.
7. Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of non-steroidal anti-inflammatory drugs. N Engl J Med 1999; 340:1888-1899.
8. Warner TD, Guiliano F, Vojnovic I, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 1999;96:7563-7568.
9. Bergh MS, Budsberg SC. The coxib NSAIDs: potential clinical and pharmacologic importance in veterinary medicine. J Vet Intern Med 2005;19:633-645.
10. Forsyth SF, Guilford WG, Haslett SJ, et al. Endoscopy of the gastroduodenal mucosa after carprofen, meloxicam and ketoprofen administration in dogs. J Small Anim Pract 1998;39:421-424.
11. Reimer ME, Johnston SA, Leib MS, et al. The gastroduodenal effects of buffered aspirin, carprofen, and etodolac in healthy dogs. J Vet Intern Med 1999;13:472-477.
12. Brideau C, Van Staden C, Chan CC. In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats. Am J Vet Res 2001;62:1755-1760.
13. Vane JR, Bottin RM. Mechanism of action of anti-inflammatory drugs. Adv Exp Med Biol 1997;433:131-138.
14. Ray-Mugford P, Benn SJ, LaMarre J, et al. In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs. Am J Vet Res 2000;61:802-810.
15. Fox SM, Johnston SA. Use of carprofen for the treatment of pain and inflammation in dogs. J Am Vet Med Assoc 1997; 210:1493-1498.
16. Lipscomb VJ, AliAbadi FS, Lees P, et al. Clinical efficacy and pharmacokinetics of carprofen in the treatment of dogs with osteoarthritis. Vet Rec 2002;150:684-689.
17. Smith SA. Deracoxib. Compend Contin Educ Small Anim Pract 2003;25:452-454.
18. Lascelles BDX, Blikslager AT, Fox ST, et al. Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002-2003). J Am Vet Med Assoc 2005; 227:1112-1117.
19. Millis DL, Conzemius MG, Wells KL, et al. A multicenter clinical study of the effect of deracoxib, a COX-2 selective drug, on postoperative analgesia associated with cranial cruciate ligament surgery in dogs. FDA Freedom of Information Summary. Rockville, Md: FDA, 2002.
20. Millis DL, Weigel JP, Moyers T, et al. Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. Vet Ther 2002;3:453-464.
21. Boston SE, Moens NMM, Kruth SA, et al. Endoscopic evaluation of the gastroduodenal mucosa to determine the safety of short-term concurrent administration of meloxicam and dexamethasone in healthy dogs. Am J Vet Res 2003;64:1369-1375.
22. Brzozowski T, Konturek PC, Konturek SJ, et al. Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. Microsc Res Tech 2001; 53:343-353.
23. Kishimoto Y, Wada K, Nakamoto K, et al. Levels of cyclooexygenase-1 and -2 mRNA expressions at various stages of acute gastric injury induced by ischemia-reperfusion in rats. Arch Biochem Biophys 1998;352:153-157.
24. Graham DY, Smith JL, Spjut HJ, et al. Gastric adaption: studies in humans during continuous aspirin administration. Gastroenterology 1988;95:327-333.
25. Takeuchi K, Araki H, Masakazu U, et al. Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice. J Pharmacol Exp Ther 2001;297:1160-1165.
26. Terragno NA, Terragno DA, McGiff JC. Contribution of prostaglandins to the renal circulation in conscious, anesthetized, and laparotomized dogs. Circ Res 1977;40:590-595.
27. Cook DJ, Witt LG, Cook RJ, et al. Stress ulcer prophylaxis in the critically ill: a meta-analysis. Am J Med 1991;91:519-527.
28. Shuster DP, Rowley H, Feinstein S, et al. Prospective evaluation of the risk of upper gastrointestinal bleeding after admission to a medical intensive care unit. Am J Med 1984;76:623-630.
29. Murray MJ, Schusser GF, Pipers FS, et al. Factors associated with gastric lesions in Thoroughbred horses. Equine Vet J 1996; 28:368-374.
30. Davis MS, Willard MD, Nelson SL, et al. Prevalence of gastric lesions in racing Alaskan sled dogs. J Vet Intern Med 2003;17:311-314.
31. Leung FW, Itoh M, Hirabayashi K, et al. Role of blood flow in gastric and duodenal mucosal injury in the rat. Gastroenterology 1985;88:281-289.
32. Martinez-Augustin O, Sanchez de Medina F Jr, Sanchez de Medina F. Effect of psychogenic stress on gastrointestinal function. J Physiol Biochem 2000;56:259-274.
33. Stanton ME, Bright RM. Gastroduodenal ulceration in dogs: retrospective study of 43 cases and literature review. J Vet Intern Med 1989;3:238-244.
34. Ko JCH, Miyabiyashi T, Mandsager RE, et al. Renal effects of carprofen administered to healthy dogs anesthetized with propofol and isoflurane. J Am Vet Med Assoc 2000;217:346-349.
35. Eaton KA, Dewhirst FE, Paster BJ, et al. Prevalence and varieties of Helicobacter species in dogs from random source and pet dogs: animal and public health implications. J Clin Microbiol 1996;34:3165-3170.