A unique amino acid substitution, T126I, in human genotype C of hepatitis B virus S gene and its possible influence on antigenic structural change

Gene

Volumn 383, Issue , 2006, Pages 43-51

  Ren, Fengrong ^a   Tsubota, Asahito ^b,d   Hirokawa, Takatsugu ^a,c   Kumada, Hiromitsu ^d   Yang, Ziheng ^e   Tanaka, Hiroshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d TORANOMON HOSPITAL   (Japan)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

'a' determinant; 3D structure; Ancestral viral sequence; Chronic HBV infection; Clinical outcome; Positive selection

Indexed keywords

AMINO ACID; HEPATITIS B SURFACE ANTIGEN;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ANTIGENICITY; ARTICLE; CLINICAL ARTICLE; COMPARATIVE GENE MAPPING; COMPARATIVE STUDY; FEMALE; GENBANK; GENE SEQUENCE; GENE STRUCTURE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; MALE; MOLECULAR EVOLUTION; MOLECULAR PHYLOGENY; NATURAL SELECTION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN STRUCTURE; STATISTICAL SIGNIFICANCE; STRUCTURE ANALYSIS; VIRUS GENE; VIRUS STRAIN;

ADULT; AGED; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; EPITOPES; FEMALE; GENES, VIRAL; GENOTYPE; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; MALE; MIDDLE AGED; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID;

HEPATITIS B VIRUS;

EID: 33750081785     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2006.07.018     Document Type: Article

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