A single prion protein peptide can elicit a panel of isoform specific monoclonal antibodies

Peptides

Volumn 27, Issue 11, 2006, Pages 2695-2705

  Vranac, Tanja ^a   Hartman, Katrina Pretnar ^a   Popović, Mara ^b   Venturini, Anja ^a   Žerovnik, Eva ^c   Čurin Šerbec, Vladka ^a  

^a BLOOD TRANSFUSION CENTRE OF SLOVENIA   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c JO EF STEFAN INSTITUTE   (Slovenia)

Author keywords

Anti TSE vaccine; Epitope conformation; Immune tolerance; Monoclonal antibody; Peptide antigen; Prion protein

Indexed keywords

ASPARTYLGLUTAMYLTYROSYLSERYLASPARAGINYLGLUTAMINYLASPARAGINYLASPARAGINYL PHENYLALANYLVALYLHISTIDYLASPARTYLCYSTEINYL; CYSTEINYLISOLEUCYLHISTIDYLPHENYLALANYLGLYCYLSERYLASPARTYLTYROSYLGLUTAMYL ASPARTYLARGINYLTYROSYLTYROSYL; CYSTEINYLISOLEUCYLTHREONYLGLUTAMINYLTYROSYLGLUTAMYLARGINYLGLUTAMYLSERYL GLUTAMINYLALANYLTYROSYLTYROSYL; HEMOCYANIN; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; PEPTIDE; PRION PROTEIN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNE SYSTEM; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; BRAIN; CIRCULAR DICHROISM; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDES; PRIONS;

EID: 33750081141     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2006.05.026     Document Type: Article

References (36)

1. Aucouturier P., Carp R.I., Carnaud C., and Wisniewski T. Prion diseases and the immune system. Clin Immunol 96 (2000) 79-85
2. Beringue V., Vilette D., Mallinson G., Archer F., Kaisar M., Tayebi M., et al. PrPSc binding antibodies are potent inhibitors of prion replication in cell lines. J Biol Chem 279 38 (2004) 39671-39676
3. Calzolai L., and Zahn R. Influence of pH on NMR structure and stability of the human prion protein globular domain. J Biol Chem 278 37 (2003) 35592-35596
4. Cashman N.R., and Caughey B. Prion diseases-close to effective therapy?. Nat Rev Drug Discov 3 10 (2004) 874-884
5. Cordeiro Y., Kraineva J., Ravindra R., Lima L.M., Gomes M.P., Foguel D., et al. Hydration and packing effects on prion folding and beta-sheet conversion. High pressure spectroscopy and pressure perturbation calorimetry studies. J Biol Chem 279 31 (2004) 32354-32359
6. Čurin Šerbec V., Bresjanac M., Popović M., Pretnar Hartman K., Galvani V., Rupreht R., et al. Monoclonal antibody against a peptide of human prion protein discriminates between Creutzfeldt-Jakob disease-affected and normal brain tissue. J Biol Chem 279 5 (2004) 3694-3698
7. Dima R.I., and Thirumalai D. Probing the instabilities in the dynamics of helical fragments from mouse PrPC. Proc Natl Acad Sci USA 101 43 (2004) 15335-15340
8. Enari M., Flechsig E., and Weissmann C. Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc Natl Acad Sci USA 98 16 (2001) 9295-9299
9. Frank R. Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron 48 22 (1992) 9217-9232
10. Galvani V., Rupreht R.R., Čurin Šerbec V., and Vidan-Jeras B. Genetic risk factors associated with Creutzfeld-Jakob disease in Slovenians and a rapid typing for PRNP codon 129 single nucleotide polymorphism. Transfus Med 15 3 (2005) 197-207
11. Gu W., Wang T., Zhu J., Shi Y., and Liu H. Molecular dynamics simulation of the unfolding of the human prion protein domain under low pH and high temperature conditions. Biophys Chem 104 1 (2003) 79-94
12. Harmeyer S., Pfaff E., and Groschup M.H. Synthetic peptide vaccines yield monoclonal antibodies to cellular and pathological prion proteins of ruminants. J Gen Virol 79 (1998) 937-945
13. Hornemann S., and Glockshuber R. A scrapie-like unfolding intermediate of the prion protein domain PrP(121-231) induced by acidic pH. Proc Natl Acad Sci USA 95 11 (1998) 6010-6014
14. Juntes P., Zabavnik Piano J., Čurin Šerbec V., Kovač Z., and Pogačnik M. Neuropathological lesions in the first case of bovine spongiform encephalopathy in Slovenia. S:lo Vet Res 39 2 (2002) 105-114 [English edition]
15. Kaneko K., Zulianello L., Scott M., Cooper C.M., Wallace A.C., James T.L., et al. Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation. Proc Natl Acad Sci USA 94 19 (1997) 10069-10074
16. Kascsak R.J., Rubenstein R., Merz P.A., Tonna-De Masi M., Fersko R., Carp R.I., et al. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins. J Virol 61 (1987) 3688-3693
17. Korth C., Stierli B., Streit P., Moser M., Schaller O., Fischer R., et al. Prion (PrPSc)-specific epitope defined by a monoclonal antibody. Nature 390 (1997) 74-77
18. Kuczius T., Buschmann A., Zhang W., Karch H., Becker K., Peters G., et al. Cellular prion protein acquires resistance to proteolytic degradation following copper ion binding. Biol Chem 385 8 (2004) 739-747
19. Lee C.M., Onesime D., Reddy C.D., Dhanasekaran N., and Reddy E.P. JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proc Natl Acad Sci USA 99 22 (2002) 14189-14194
20. Lerner R.A. Antibodies of predetermined specificity in biology and medicine. Adv Immunol 36 (1984) 1-44
21. Matsushita K., Horiuchi H., Furusawa S., Horiuchi M., Shinagawa M., and Matsuda H. Chicken monoclonal antibodies against synthetic bovine prion protein peptide. J Vet Med Sci 60 6 (1998) 777-779
22. Notari S., Capellari S., Giese A., Westner I., Baruzzi A., Ghetti B., et al. Effects of different experimental conditions on the PrPSc core generated by protease digestion: implications for strain typing and molecular classification of CJD. J Biol Chem 279 16 (2004) 16797-16804
23. Paramithiotis E., Pinard M., Lawton T., LaBoissiere S., Leathers V.L., Zou W.Q., et al. A prion protein epitope selective for the pathologically misfolded conformation. Nat Med 9 7 (2003) 893-899
24. Peretz D., Williamson R.A., Kaneko K., Vergara J., Leclerc E., Schmitt-Ulms G., et al. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature 412 6848 (2001) 739-743
25. Price K.M. Production and characterisation of synthetic peptide-derived antibodies. In: Ritter M.A., and Ladyman (Eds). Monoclonal antibodies: production, engineering and clinical application (1995), Cambridge University Press 60-84
26. Prusiner S.B. Prions. Proc Natl Acad Sci USA 95 (1998) 13363-13383
27. Souan L., Tal Y., Felling Y., Cohen I.R., Taraboulos A., and Mor F. Modulation of proteinase-K resistant prion protein by prion peptide immunization. Eur J Immunol 31 8 (2001) 2338-2346
28. Swietnicki W., Petersen R., Gambetti P., and Surewicz W.K. pH-Dependent stability and conformation of the recombinant human prion protein PrP(90-231). J Biol Chem 272 44 (1997) 27517-27520
29. Takahashi H., Takahashi R.H., Hasegawa H., Horiuchi M., Shinagawa M., Yokoyama T., et al. Characterization of antibodies raised against bovine-PrP-peptides. J Neurovirol 5 3 (1999) 300-307
30. Ulrih N.P., Skrt M., Veranic P., Galvani V., Veranič T., and Čurin Šerbec V. Oligomeric forms of peptide fragment PrP(214-226) in solution are preferentially recognized by PrP(Sc)-specific antibody. Biochem Biophys Res Commun 344 4 (2006) 1320-1326
31. Van Regenmortel M.H.V. Antigenic cross-reactivity between proteins and peptides: new insights and applications. Trends Biochem Sci 12 (1987) 237-240
32. Van Regenmortel M.H.V. Which structural features determine protein antigenicity?. Trends Biochem Sci 11 (1986) 36-39
33. Vogtherr M., Grimme S., Elshorst B., Jacobs D.M., Fiebig K., Griesinger C., et al. Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem 46 17 (2003) 3563-3564
34. Way G., Morrice N., Smythe C., and O'Sullivan A.J. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. Mol Biol Cell 13 9 (2002) 3344-3354
35. White A.R., Enever P., Tayebi M., Mushens R., Linehan J., Brandner S., et al. Monoclonal antibodies inhibit prion replication and delay the development of prion disease. Nature 422 6927 (2003) 80-83
36. Yokoyama T., Kimura K., Tagawa Y., and Yuasa N. Preparation and characterization of antibodies against mouse prion protein (PrP) peptides. Clin Diagn Lab Immunol 2 2 (1995) 172-176