Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction

Organic and Biomolecular Chemistry

Volumn 1, Issue 23, 2003, Pages 4138-4140

  Sutherland, Alan G ^a   Alvarez, Juan ^b   Ding, Weidong ^a   Foreman, K W ^b   Kenny, Cynthia Hess ^a   Labthavikul, Pornpen ^a   Mosyak, Lidia ^b   Petersen, Peter J ^a   Rush III, Thomas S ^b   Ruzin, Alexey ^a   Tsao, Desiree H H ^b   Wheless, Karen L ^a  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CRYSTAL STRUCTURE; DRUG PRODUCTS; HYDROPHOBICITY; MOLECULES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; X RAY ANALYSIS;

ANTIMICROBIAL AGENT; CARBOXYBIPHENYLINDOLE INHIBITORS; GRAM NEGATIVE BACTERIA; OXAZOLE;

PROTEINS;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

BACTERIAL PROTEIN; CARRIER PROTEIN; CELL CYCLE PROTEIN; CYTOSKELETON PROTEIN; ESCHERICHIA COLI PROTEIN; FTSZ PROTEIN, BACTERIA; INDOLE; INDOLE DERIVATIVE; ZIPA PROTEIN, E COLI;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; IC 50; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

BACTERIAL PROTEINS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CYTOSKELETAL PROTEINS; DRUG DESIGN; ESCHERICHIA COLI PROTEINS; INDOLES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 5044241040     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b312016c     Document Type: Article

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