Impact of freezing procedure and annealing on the physico-chemical properties and the formation of mannitol hydrate in mannitol-sucrose-NaCl formulations

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 64, Issue 3, 2006, Pages 316-325

  Hawe, Andrea ^a   Frieß, Wolfgang ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Annealing; Freezing; Lyophilization; Mannitol hydrate; NaCl

Indexed keywords

MANNITOL; SODIUM CHLORIDE; SUCROSE;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; FREEZE DRYING; FREEZING; GLASS TRANSITION TEMPERATURE; LOW TEMPERATURE; PHYSICAL CHEMISTRY; TEMPERATURE MEASUREMENT; TITRIMETRY; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; EXCIPIENTS; FREEZE DRYING; MANNITOL; SODIUM CHLORIDE; SOLUTIONS; SUCROSE; TITRIMETRY; TRANSITION TEMPERATURE; WATER;

EID: 33750065701     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.06.002     Document Type: Article

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