Freeze-drying: In situ observations using cryoenvironmental scanning electron microscopy and differential scanning calorimetry

Journal of Pharmaceutical Sciences

Volumn 85, Issue 6, 1996, Pages 631-637

  Meredith, Paul ^a,c   Donald, Athene M ^a   Payne, Robin S ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MANNITOL; SOLVENT; WATER;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; FREEZE DRYING; SCANNING ELECTRON MICROSCOPY;

EID: 0029941173     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js950324z     Document Type: Article

References (37)

1. McDowell, A. W.; Chang, J. J.; Freeman, R.; Lepault, J.; Walter, C. A.; Doubochet, J. J. Microsc. 1983, 131, 1.
2. Glauert, A. M. Fixation, dehydration and embedding of biological specimens. In Practical Methods in Electron Microscopy; Glauert, A. M., Ed.; North Holland-American Elsevier: Amsterdam, 1975.
3. Vijayendran, B. R.; Bone, T.; Sawyer, L. C. J. Dispersion Sci. Technol. 1982, 3 (1), 81.
4. Robinson, V. N. E. J. Phys. E: Sci. Instrum. 1975, 7, 650.
5. Double, D. D.; Hellawell, A.; Perry, S. J. Proc. R. Soc. London 1978, A359, 435.
6. Jennings, H. M.; Dalgleish, B. J.; Pratt, P. L. J. Am. Ceram. Soc. 1981, 64, 576.
7. Moncrieff, D. A.; Barker, P. R.; Robinson, V. N. E. J. Phys. D: Appl. Phys. 1979, 12, 481.
8. Moncrieff, D. A.; Robinson, V. N. E.; Harris, L. B. J. Phys. D: Appl. Phys. 1978, 11, 2315.
9. Danilatos, G. D. Scanning 1981, 4, 9.
10. Danilatos, G. D.; Postle, R. Micron 1983, 14, 41.
11. Danilatos, G. D. Scanning 1985, 7, 26.
12. Danilatos, G. D. Scanning 1987, 12, 23.
13. Peters, K. R. Microelectron Eng. 1992, 17, 455.
14. Farley, A. N.; Shah, J. S. J. Microsc. 1990, 158, 379.
15. Farley, A. N.; Shah, J. S. J. Microsc. 1990, 158, 389.
16. Danilatos, G. D. Scanning Microsc. 1990, 4, 299.
17. Danilatos, G. D. J. Microsc. 1990, 160, 9.
18. Danilatos, G. D. Microsc. Res. 1993, 25, 529.
19. Ito, Y. Chem. Pharm. Bull. 1970, 18, 1509.
20. Nail, S. L.; Her, L. M.; Proffitt, C. P. B.; Nail, L. L. Pharm. Res. 1994, 11, 1098.
21. Rey, L. R. Ann. N. Y. Acad. Sci. 1960, 85, 510.
22. Rashmikant, M. P.; Hurwitz, A. J. Pharm. Sci. 1972, 61, 1807.
23. Hatley, R. H. M. Dev. Biol. Stand. 1991, 74, 105.
24. Williams, N. A.; Polli, G. P. J. Parenter. Sci. Technol. 1984, 38, 48.
25. Wade, A.; Weller, P. J. In Handbook of Pharmaceutical Excipients, 2nd Ed.; Wade, A., Weller, P. J., Eds.; The Pharmaceutical Press: London, 1994; pp 294-295.
26. Berman, H. M.; Jeffrey, G. A.; Rosenstein, R. D. Acta Crystallogr. 1968, B24, 442.
27. Levine, H.; Slade, L. Collapse phenomena- a unifying concept for interpreting the behaviour of low moisture food, In Food structure- its recreation and evaluation; Blanshard, J. M. V., Mitchell, J. R., Eds.; Butterworths: London, 1988; pp 149-180.
28. Franks, F. The properties of aqueous solutions at subzero temperatures. In: Water: a comprehensive treatise; Franks, F., Ed.; Plenum Press: New York, 1982; Vol. 7.
29. Hatley, R. H. M. Dev. Biol. Stand. 1991, 74, 105.
30. Patel, R. M.; Hurwitz, A. J. Pharm. Sci. 1972, 61, 1806.
31. Franks, F. Dev. Biol. Stand. 1991, 74, 9.
32. Cameron, R. E.; Donald, A. M. J. Microsc. 1994, 173, 227.
33. Murrell, J. N.; Boucher, E. A. In Properties of Liquids and Solutions; Murrell, J. N., Boucher, E. A., Eds.; John Wiley & Sons: New York, 1982; pp 152-179.
34. Williams, N. A.; Lee, Y.; Polli, G. P.; Jenings, T. A. J. Parenter. Sci. Technol. 1986, 40, 135.
35. Luyet, B. J. Ann. N.Y. Acad. Sci. 1965, 125, 502.
36. Gatlin, L.; DeLuca, P. P. J. Parenter. Drug Assoc. 1980, 34, 398.
37. Mackenzie, A. P. Dev. Biol. Stand. 1977, 36, 51.