Liposome-mediated gene transfer of K1-5 suppresses tumor development and improves the prognosis of hepatocellular carcinoma in mice

Medical Molecular Morphology

Volumn 39, Issue 2, 2006, Pages 72-78

  Torimura, Takuji ^a   Ueno, Takato ^a   Sata, Michio ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antiangiogenesis; Gene therapy; Growth inhibition; Hepatocellular carcinoma; Kringle 1 5

Indexed keywords

ALANINE AMINOTRANSFERASE; ANGIOGENESIS INHIBITOR; ANGIOPOIETIN 1; ANGIOPOIETIN 2; KRINGLE 1 5 PROTEIN; LIPOSOME; UNCLASSIFIED DRUG; VASCULOTROPIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN COS1; CONFERENCE PAPER; CONTROLLED STUDY; GENE THERAPY; GENE TRANSFER; HEPATOMA CELL; LIVER CELL; LIVER CELL CARCINOMA; LIVER METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR GROWTH; WESTERN BLOTTING;

ALANINE TRANSAMINASE; ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANIMALS; BODY WEIGHT; CARCINOMA, HEPATOCELLULAR; CATTLE; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; COS CELLS; DNA, COMPLEMENTARY; ENDOTHELIAL CELLS; GENE THERAPY; KRINGLES; LIPOSOMES; LIVER; MICE; MICE, NUDE; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; SURVIVAL ANALYSIS; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33750046350     PISSN: 18601480     EISSN: 18601499     Source Type: Journal    
DOI: 10.1007/s00795-006-0319-6     Document Type: Conference Paper

References (43)

1. M Kirsch G Schackert PM Black 2004 Metastasis and angiogenesis Cancer Treat Res 117 285 304
2. XM Li ZY Tang G Zhou YK Lui SL Ye 1998 Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma J Exp Clin Cancer Res 17 13 17
3. L Holmgren MS O'Reilly J Folkman 1995 Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression Nat Med 1 149 153
4. M Miyagami Y Katayama 2005 Angiogenesis of glioma: evaluation of ultrastructural characteristics of microvessels and tubular bodies (Weibel-Palade) in endothelial cells and immunohistochemical findings with VEGF and p53 protein Med Mol Morphol 38 36 42
5. MS O'Reilly L Holmgren Y Shing C Chen RA Rosenthal M Moses WS Lane Y Cao EH Sage J Folkman 1994 Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma Cell 79 315 328
6. MS O'Reilly T Boehm Y Shing N Fukai G Vasios WS Lane E Flynn JR Birkhead BR Olsen J Folkman 1997 Endostatin: an endogenous inhibitor of angiogenesis and tumor growth Cell 88 277 285
7. MS O'Reilly S Pirie-Shepherd WS Lane J Folkman 1999 Antiangiogenic activity of the cleaved conformation of the serpin antithrombin Science 285 1926 1928
8. K Matsumoto H Ishikawa D Nishimura K Hamasaki K Nakao K Eguchi 2004 Antiangiogenic property of pigment epithelium-derived factor in hepatocellular carcinoma Hepatology 40 252 259
9. M Elkin A Orgel HK Kleinman 2004 An angiogenic switch in breast cancer involves estrogen and soluble vascular endothelial growth factor receptor 1 J Natl Cancer Inst 96 875 878
10. Y Maeshima A Sudhakar JC Lively K Ueki S Kharbanda CR Kahn N Sonenberg RO Hynes R Kalluri 2002 Tumstatin, an endothelial cell-specific inhibitor of protein synthesis Science 295 140 143
11. Z Cao BC Baguley LM Ching 2001 Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) Cancer Res 61 1517 1521
12. Y Hayakawa K Takeda H Yagita MJ Smyth L Van Kaer K Okumura I Saiki 2002 IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide Blood 100 1728 1733
13. S Indraccolo E Gola A Rosato S Minuzzo W Habeler V Tisato V Roni G Esposito M Morini A Albini DM Noonan M Ferrantini A Amadori L Chieco-Bianchi 2002 Differential effects of angiostatin, endostatin and interferon-alpha(1) gene transfer on in vivo growth of human breast cancer cells Gene Ther 9 867 878
14. Z von Marschall A Scholz T Cramer G Schafer M Schirner K Oberg B Wiedenmann M Hocker S Rosewicz 2003 Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis J Natl Cancer Inst 95 437 448
15. Y Cao L Xue 2004 Angiostatin Semin Thromb Hemostas 30 83 93
16. Y Cao RW Ji D Davidson J Schaller D Marti S Sohndel SG [tmp] McCance MS O'Reilly M Llinas J Folkman 1996 Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells J Biol Chem 271 29461 29467
17. Y Cao R Cao N Veitonmaki 2002 Kringle structures and antiangiogenesis Curr Med Chem Anti-Cancer Agents 2 667 681
18. Y Cao A Chen SS An RW Ji D Davidson M Llinas 1997 Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth J Biol Chem 272 22924 22928
19. R Cao HL Wu N Veitonmaki P Linden J Farnebo GY Shi Y Cao 1999 Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis Proc Natl Acad Sci U S A 96 5728 5733
20. QR Chen D Kumar SA Stass AJ Mixson 1999 Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice Cancer Res 59 3308 3312
21. BV Sauter O Martinet WJ Zhang J Mandeli SL Woo 2000 Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases Proc Natl Acad Sci U S A 97 4802 4807
22. A Auricchio KC Behling AM Maguire EM O'Connor J Bennett JM Wilson MJ Tolentino 2002 Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents Mol Ther 6 490 494
23. A Calvo AL Feldman SK Libutti JE Green 2002 Adenovirus-mediated endostatin delivery results in inhibition of mammary gland tumor growth in C3(1)/SV40 T-antigen transgenic mice Cancer Res 62 3934 3938
24. Y Li Y Jin H Chen G Jie G Tobelem JP Caen ZC Han 2003 Suppression of tumor growth by viral vector-mediated gene transfer of N-terminal truncated platelet factor 4 Cancer Biother Radiopharm 18 829 840
25. T Noro K Miyake N Suzuki-Miyake T Igarashi E Uchida T Misawa Y Yamazaki T Shimada 2004 Adeno-associated viral vector-mediated expression of endostatin inhibits tumor growth and metastasis in an orthotropic pancreatic cancer model in hamsters Cancer Res 64 7486 7490
26. V Schmitz L Wang M Barajas C Gomar J Prieto C Qian 2004 Treatment of colorectal and hepatocellular carcinomas by adenoviral mediated gene transfer of endostatin and angiostatin-like molecule in mice Gut 53 561 567
27. AM Di Bisceglie VK Rustgi JH Hoofnagle GM Dusheiko MT Lotze 1988 NIH conference. Hepatocellular carcinoma Ann Intern Med 108 390 401
28. H Honda T Tajima K Kajiyama T Kuroiwa K Yoshimitsu H Irie H Aibe M Shimada K Masuda 1999 Vascular changes in hepatocellular carcinoma: correlation of radiologic and pathologic findings AJR Am J Roentgenol 173 1213 1217
29. O Matsui M Kadoya T Kameyama J Yoshikawa T Takashima Y Nakanuma M Unoura K Kobayashi R Izumi M Ida 1991 Benign and malignant nodules in cirrhotic livers: distinction based on blood supply Radiology 178 493 497
30. D Semela JF Dufour 2004 Angiogenesis and hepatocellular carcinoma J Hepatol 41 864 880
31. H Toyoda Y Fukuda T Hayakawa T Kumada S Nakano 1997 Changes in blood supply in small hepatocellular carcinoma: correlation of angiographic images and immunohistochemical findings J Hepatol 27 654 660
32. N Veitonmaki R Cao LH Wu TL Moser B Li SV Pizzo B Zhivotovsky Y Cao 2004 Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis Cancer Res 64 3679 3686
33. NS Templeton DD Lasic PM Frederik HH Strey DD Roberts GN Pavlakis 1997 Improved DNA: liposome complexes for increased systemic delivery and gene expression Nat Biotechnol 15 647 652
34. MS O'Reilly L Holmgren C Chen J Folkman 1996 Angiostatin induces and sustains dormancy of human primary tumors in mice Nat Med 2 689 692
35. LA Liotta 1986 Tumor invasion and metastases - role of the extracellular matrix: Rhoads Memorial Award lecture Cancer Res 46 1 7
36. Y Cao MS O'Reilly B Marshall E Flynn RW Ji J Folkman 1998 Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases J Clin Invest 101 1055 1063
37. J Holash PC Maisonpierre D Compton P Boland CR Alexander D Zagzag GD Yancopoulos SJ Wiegand 1999 Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF Science 284 1994 1998
38. MS O'Reilly 2002 Vessel maneuvers: vaccine targets tumor vasculature Nat Med 8 1352 1353
39. PF Sumariwalla Y Cao HL Wu M Feldmann EM Paleolog 2003 The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis Arthritis Res Ther 5 R32 R39
40. M Kin T Torimura T Ueno T Nakamura R Ogata M Sakamoto S Tamaki M Sata 2000 Angiogenesis inhibitor TNP-470 suppresses the progression of experimentally-induced hepatocellular carcinoma in rats Int J Oncol 16 375 382
41. KR Kim HE Moon KW Kim 2002 Hypoxia-induced angiogenesis in human hepatocellular carcinoma J Mol Med 80 703 714
42. H Yoshiji S Kuriyama J Yoshii M Yamazaki M Kikukawa H Tsujinoue T Nakatani H Fukui 1998 Vascular endothelial growth factor tightly regulates in vivo development of murine hepatocellular carcinoma cells Hepatology 28 1489 1496
43. H Yoshiji S Kuriyama DJ Hicklin J Huber J Yoshii Y Miyamoto M Kawata Y Ikenaka T Nakatani H Tsujinoue H Fukui 1999 KDR/Flk-1 is a major regulator of vascular endothelial growth factor-induced tumor development and angiogenesis in murine hepatocellular carcinoma cells Hepatology 30 1179 1186