Effects of clonidine on prolonged postoperative sympathetic response

Critical Care Medicine

Volumn 25, Issue 7, 1997, Pages 1147-1152

  Dorman, Todd ^a   Clarkson, Kevin ^c   Rosenfeld, Brian A ^a   Shanholtz, Carl ^b   Lipsett, Pamela A ^a   Breslow, Michael J ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Catecholamine; Clonidine; Cortisol; Cytokine; Hemodynamics; Interleukin 6; Stress response

Indexed keywords

ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; NORADRENALIN; PLACEBO;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; BILIARY TRACT SURGERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SCREENING; FEMALE; HUMAN; HYPERTENSION; MALE; NORADRENALIN BLOOD LEVEL; ORAL DRUG ADMINISTRATION; PANCREAS SURGERY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURGICAL PATIENT; SYMPATHETIC TONE; TRANSDERMAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ADRENERGIC ALPHA-AGONISTS; CATECHOLAMINES; CLONIDINE; DOUBLE-BLIND METHOD; FEMALE; HEMODYNAMIC PROCESSES; HUMANS; HYDROCORTISONE; INTERLEUKIN-6; MALE; MIDDLE AGED; NITROGEN; POSTOPERATIVE COMPLICATIONS; STRESS; SURGICAL PROCEDURES, OPERATIVE; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOLYTICS;

EID: 0030843745     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199707000-00015     Document Type: Article

References (20)

1. Forrest JB: Multicenter study of general anesthesia. II. Results. Anesthesiology 1992; 76:3-15
2. Buck N: The report of a confidential enquiry into perioperative death. London, Nuffield Provincial Hospitals Trust, 1982
3. Cohen MM: Does anesthesia contribute to operative mortality? JAMA 1988; 260:2859-2863
4. Christopherson R, Beattie C, Gottlieb S, et al: Perioperative morbidity in patients randomized to epidural or general anesthesia for lower extremity vascular surgery. Anesthesiology 1993; 79: 422-434
5. Yeager MP, Glass DD, Neff R, et al: Epidural anesthesia and analgesia in high-risk surgical patients. Anesthesiology 1987; 66:729-736
6. Breslow MJ, Jordan DA, Christopherson R, et al: Epidural morphine decreases postoperative hypertension by attenuating sympathetic nervous system hyperactivity. JAMA 1989; 261:3577-3581
7. Ghignone M, Calvillo O, Quintin L: Anesthesia and hypertension: The effect of clonidine on perioperative hemodynamics and isoflurane requirements. Anesthesiology 1987; 67:3-10
8. Flacke JW, Bloor BC, Flacke WE, et al: Reduced narcotic requirement by clonidine with improved hemodynamic and adrenergic stability in patients undergoing coronary bypass surgery. Anesthesiology 1987; 67:11-19
9. Helbo-Hansen S, Fletcher R, Lundberg D, et al: Clonidine and the sympatico-adrenal response to coronary artery bypass surgery. Acta Anaesthesiol Scand 1986; 30:235-242
10. Ghignone M, Quintin L, Duke PC, et al: Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation. Anesthesiology 1986; 64: 36-42
11. Segal IS, Jarvis DJ, Duncan SR, et al: Clinical efficacy of oral-transdermal clonidine combinations during the perioperative period. Anesthesiology 1991; 74:220-225
12. Quinton L, Roudot F, Roux C, et al: Effect of clonidine on the circulation and vasoactive hormones after aortic surgery. Br J Anaesth 1991; 66:108-115
13. Engelman E, Lipszyc M, Gilbart E, et al: Effects of clonidine on anesthetic drug requirements and hemodynamic response during aortic surgery. Anesthesiology 1989; 71:178-187
14. Siri FM, Kauer CD: Plasma catecholamine measurements in resting and stressed conscious rats, using high performance liquid chromatography with electrochemical detection. Life Sci 1985; 37:1923-1931
15. Segal IS, Jarvis DJ, Duncan SR, et al: Clinical efficacy of oral-transdermal clonidine combinations during perioperative period. Anesthesiology 1991; 74:220-225
16. Chernow B, Alexander HR, Smallridge RC, et al: Hormonal responses to graded surgical stress. Arch Intern Med 1987; 147:1273-1278
17. Young JB, Rosa RM, Landsberg L: Dissociation of sympathetic nervous system and adrenal medullary responses. Am J Physiol 1984; 247:E35-E40
18. Frank SM, Beattie C, Christopherson R, et al: Epidural versus general anesthesia, ambiant operating room temperature, and patient age as predictors of inadvertent hypothermia. Anesthesiology 1992; 77:252-257
19. Beattie WS, Buckley DN, Forrest JB: Epidural morphine reduces the risk of postoperative myocardial ischemia in patients with cardiac risk factors. Can J Anaesth 1993; 40:41-52
20. Breslow MJ, Parker SD, Frank SM, et al: Determinants of catecholamine and cortisol responses to lower extremity revascularization. Anesthesiology 1993; 79:1202-1209