Beta-blockade enhances adrenergic immunosuppression in rats via inhibition of melatonin release

Journal of Neuroimmunology

Volumn 67, Issue 2, 1996, Pages 137-142

  Liebmann, Peter M ^a   Hofer, Dietmar ^a   Felsner, Peter ^a   Wölfler, Albert ^a   Schauenstein, Konrad ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Adrenegic immunosuppression; Melatonin; Mitogen response; Noradrenaline; blocker

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; MELATONIN; MITOGENIC AGENT; NORADRENALIN; PLACEBO; PROPRANOLOL;

ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; IMMUNOMODULATION; MALE; NONHUMAN; PINEAL BODY; PRIORITY JOURNAL; RAT; T LYMPHOCYTE;

EID: 0030200143     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-5728(96)00050-1     Document Type: Article

References (31)

1. Arzt, E,S., Fernandez-Castelo, S., Finocchiaro, L.M., Criscuolo, M.E., Diaz, A., Finkielman, S. and Nahmod, V.E. (1988) Immunomodulation by indoleamines: serotonin and melatonin action on DNA and interferon-gamma synthesis by human peripheral blood mononuclear cells. J. Clin. Immunol. 8, 513-520.
2. Bellinger, D.L., Lorton, D., Feiten, S.Y. and Felten, D.L. (1992) Innervation of lymphoid organs and implications in development, aging, and autoimmunity. Int. J. Immunopharmacol. 14, 329-344.
3. Benitez-King, G. and Antón-Tay, F. (1993) Calmodulin mediates melatonin cytoskeletal effects. Experientia 49, 635-641.
4. 3H-melatonin to calmodulin. Life Sci. 53, 201-207.
5. Caroleo, M.C., Doria, G. and Nistico, G. (1994) Melatonin restores immunodepression in aged and cyclophosphamide-treated mice. Ann. N. Y. Acad. Sci. 719, 343-352.
6. Caroleo, M.C., Frasca, D., Nistico, G. and Doria, G. (1992) Melatonin as immunomodulator in immunodeficient mice. Immunopharmacology 23, 81-89.
7. Cunnick, J.E., Lysle, D.T., Kueinski, B.J. and Rabin, B.S. (1990) Evidence that shock-induced immunosuppression is mediated by adrenal hormones and peripheral β-adrenergic receptors. Pharmacol. Biochem. Behav. 36, 645-651.
8. Felsner, P., Hofer, D., Rinner. I., Mangge, H., Gruber, M., Korsatko, W. and Schauenstein, K. (1992) Continuous in vivo treatment with catecholamines suppresses in vitro reactivity of rat peripheral blood T-lymphocytes via β-mediated mechanisms. J. Neuroimmunol. 37, 47-57.
9. Felsner, P., Hofer, D., Rinner, I., Porta, S., Korsatko, W. and Schauenstein, K. (1995) Adrenergic suppression of peripheral blood T cell reactivity in the rat is due to activation of peripheral α2-receptors; J. Neuroimmunol. 57, 27-34.
10. Felten, D.L. and Felten, S.Y. (1988) Sympathetic noradrenergic innervation of immune organs. Brain Behav. Immun. 2, 293-300.
11. Finocchiaro, L.M., Arzt, E.S., Fernandez-Castelo, S., Criscuolo, M., Finkielman, S. and Nahmod, V.E. (1988) Serotonin and melatonin synthesis in peripheral blood mononuclear cells. Stimulation by interferon-gamma as part of an immunomodulatory pathway. J. Interferon. Res. 8, 705-716.
12. Heilig, M., Irwin, M., Grewal, I. and Sercarz, E. (1993) Sympathetic regulation of T-helper cell function. Brain Behav. Immun. 7, 154-163.
13. Johnson, D.L., Ashmore, R.C. and Gordon, M. A. (1981) Effects of β-adrenergic agents on the murine lymphocyte response in mitogen stimulation. J. Immunopharmacology 3, 205-219.
14. Korsatko, W., Porta, S., Sadjak. A. and Supanz, S. (1982) Implantation von Adrenalin-retard Tabletten zur Langzeituntersuchungen in Ratten. Pharmazie 37, 565-568.
15. Lissoni, P., Barni, S., Ardizzoia, A., Brivio, F., Tancini, G., Conti, A. and Maestroni, G.J. (1992a) Immunological effects of a single evening subcutaneous injection of low-dose interleukin-2 in association with the pineal hormone melatonin in advanced cancer patients. J. Biol. Regul. Homeost. Agents. 6, 132-136.
16. Lissoni, P., Barni, S., Tancini, G., Rovelli, F., Ardizzoia, A., Conti, A. and Maestroni, G.J. (1993) A study of the mechanisms involved in the immunostimulatory action of the pineal hormone in cancer patients. Oncology 50, 399-402.
17. Lissoni, P., Tisi, E., Barni, S., Ardizzoia, A., Rovelli, F., Rescaldani, R., Ballabio, D., Benenti, C., Angeli, M. and Tancini, G. (1992h) Biological and clinical results of a neuroimmunotherapy with interleukin-2 and the pineal hormone melatonin as a first line treatment in advanced non-small cell lung cancer. Br. J. Cancer. 66, 155-158.
18. Lopez-Gonzalez, M.A., Calvo, J.R., Osuna, C. and Guerrero, J.M. (1992a) Interaction of melatonin with human lymphocytes: evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMP. J. Pineal. Res. 12, 97-104.
19. Lopex-Gonzalez, M.A., Calvo J.R., Osuna, C., Rubio, A. and Guerrero. J.M. (1992b) Synergistic action of melatonin and vasoactive intestinal peptide in stimulating cyclic AMP production in human lymphocytes. J. Pineal, Res. 12, 174-180.
20. Lopez-Gonzalez, M.A., Calvo, J.R., Osuna, C., Rubio, A. and Guerrero, J.M. (1992c) Melatonin potentiates cyclic AMP production stimulated by vasoactive intestinal peptide in human lymphocytes. Neurosci. Lett. 136, 150-152.
21. Madden, K.S., Sanders, V.M. and Felten, D.L. (1995) Catecholamine influences and sympathetic neural modulation of immune responsiveness. Ann. Rev. Pharmacol. Toxicol. 35, 417-448.
22. Maestroni, G.J, and Conti, A. (1989) β-endorphin and dynorphin mimic the circadian immunoenhancing and anti-stress effects of melatonin: Int. J. Immunopharmacol. 11, 333-340.
23. + cells to release opioid agonist(s) with immunoenhancing and anti-stress properties. J. Neuroimmunol. 28, 167-176.
24. Maestroni, G.J. and Conti, A. (1991) Anti-stress role of the melatonin-immuno-opioid network: evidence for a physiological mechanism involving T cell-derived, immunoreactive β-endorphin and MET-enkephalin binding to thymic opioid receptors. Int. J. Neurosci. 61, 289-98.
25. Maestroni, G.J., Conti, A. and Pierpaoli, W. (1986) Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J. Neuroimmunol. 13, 19-30.
26. Maestroni, G.J., Covacci, V. and Conti, A. (1994) Hematopoietic rescue via T-cell-dependent, endogenous granulocyte-macrophage colony-stimulating factor induced by the pineal neurohormone melatonin in tumor-bearing mice. Cancer Res. 54, 2429-2432.
27. McLeod, S.D. and Cairncross, K.D. (1995) Preliminary evidence of a synergistic α 1-and β 1 -adrenoceptor regulation of rat pineal hydroxyindole-O-methyltransferase. Gen. Comp. Endocrinol. 97, 283-288.
28. Morrey, K.M., McLachlan, J.A., Serkin, C.D. and Bakouche, O. (1994) Activation of human monocytes by the pineal hormone melatonin. J. Immunol. 153, 2671-2680.
29. Pioli, C., Caroleo, M.C., Nistico, G. and Doria, G. (1993) Melatonin increases antigen presentation and amplifies specific and non specific signals forT-cell proliferation. Int. J. Immunopharmacol. 15, 463-468.
30. Steinhilber, D., Brungs, M., Werz, O., Wiesenberg, I., Danielsson, C., Kahlen, J.P., Nayeri, S., Schrader, M. and Carlberg, C. (1995) The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes. J. Biol. Chem. 270, 7037-7040.
31. Sze, S.F., Liu, W.K. and Ng, T.B. (1993) Stimulation of murine splenocytes by melatonin and methoxytryptamine. J. Neural Transm. Gen. Sect. 94, 115-126.