Structural and functional effects of tryptophans inserted into the membrane-binding and substrate-binding sites of human group IIA phospholipase A2

Biochemistry

Volumn 45, Issue 41, 2006, Pages 12448-12460

  Nemec, Kathleen N ^a   Pande, Abhay H ^a,c   Qin, Shan ^a,d   Urbauer, Ramona J Bieber ^b   Tan, Shuhua ^a,e   Moe, David ^a,f   Tatulian, Suren A ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

^b Davison Life Sciences Complex ^*  (United States)

^c BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^f VaxDesign Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BIOLOGICAL MEMBRANES; MOLECULAR ORIENTATION; MOLECULAR STRUCTURE; PHOSPHOLIPIDS;

INFLAMMATORY MEDIATORS; LYSO-PHOSPHOLIPIDS; MEMBRANE BINDING SURFACE; TRYPTOPHAN;

ENZYMES;

AMINO ACID; FATTY ACID; LIPID; LYSOPHOSPHOLIPID; PHENYLALANINE; PHOSPHOLIPASE A2; TRYPTOPHAN DERIVATIVE; VALINE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; INFLAMMATION; MEMBRANE BINDING; MEMBRANE STRUCTURE; MUTANT; MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE;

BASE SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; DNA PRIMERS; ELECTROSTATICS; HUMANS; KINETICS; MEMBRANE LIPIDS; MUTAGENESIS, SITE-DIRECTED; PHOSPHOLIPASES A; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

EID: 33750037284     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061440r     Document Type: Article

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