Liver expression of hepcidin and other iron genes in two mouse models of β-thalassemia

Haematologica

Volumn 91, Issue 10, 2006, Pages 1336-1342

  De Franceschi, Lucia ^a   Daraio, Filomena ^b   Filippini, Alida ^a   Carturan, Sonia ^b   Muchitsch, Eva Maria ^c   Roetto, Antonella ^b   Camaschella, Clara ^d  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c BAXTER BIOSCIENCE   (Austria)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Anemia; Hepcidin; Iron metabolism; Thalassemia

Indexed keywords

CYTOKINE; GLOBIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOGLOBIN; HEPCIDIN; HFE PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; IRON; RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA THALASSEMIA; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE DELETION; HEMATOCRIT; IRON OVERLOAD; LIVER HISTOLOGY; MEAN CORPUSCULAR VOLUME; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-THALASSEMIA; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; IRON; IRON OVERLOAD; LIVER; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICE, MUTANT STRAINS;

EID: 33750033613     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 2006;290:199-203.
2. Nicolas G, Bennoun M, Devaoux I, Beaumont C. Grandchamp B, Kahn A et al. Lack or hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2000;98:8780-5.
3. Nicolas G, Bennoun M, Porteu Mativet S, Beaumont C, Grandchamp B, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 2002;99:4596-601.
4. Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33: 21-2.
5. Camaschella C. Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders. Blood 2005;106:3710-7.
6. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-44.
7. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271-6.
8. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-3.
9. Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, Macfarlane J, et al. Hepcidin in iron overload disorders. Blood 2005;105: 4103-5.
10. Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein D, et al. Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer 2005 DOI 10.1002/pbo.20616
11. Rouyer-Fessard P, Leroy-Viard K, Domenget C, Mrad A, Beuzard Y. Mouse β-thalassemia, a model for the membrane defect of erythrocytes in the human disease. J Biol Chem 1990; 265:20247-51.
12. De Franceschi L, Rouyer-Fessard P, Alper SL, Jouault H, Brugnara C, Beuzard Y. Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy. Blood 1996;87:1188-95.
13. Sauvage C, Rouyer-Fessard P, Beuzard Y. Improvement of mouse β-thalassaemia by hydroxyurea. Br J Haematol 1993;84:492-6.
14. Yang B, Kirby S, Lewis J, Detloff PJ, Maeda N, Smithies O. A mouse model for β°-thalassemia. Proc Natl Acad Sci USA 1995;92:11608-12.
15. Adamsky K, Weizer O, Amariglio N, Breda L, Harmelin A, Rivella S, et al. Decreased hepcidin mRNA expression in thalassemic mice. Br J Haematol 2004;124:123-4.
16. Courselaud B, Troadec MB, Fruchon S, Ilyin G, Borot N, Leroyer P, et al. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol Dis 2004;32:283-9.
17. Bondi A, Valentino P, Daraio F, Porporato P, Gramaglia E, Carturan S, et al. Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. Haematologica 2005;90:1161-7.
18. Ilyin G, Courselaud B, Troadec MB, Pigeon C, Alizadeh M, Leroyer P, et al. Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload. FEBS Lett 2003;542:22-6.
19. De Franceschi L, Turrini F, Honczarenko M, Ayi K, Rivera A, Fleming MD, et al. In vivo reduction of erythrocyte oxidant stress in a murine model of β-thalassemia. Haematologica 2004;89:1287-98.
20. Lou DQ, Nicolas G, Lesbordes JC, Viatte L, Grimber G, Szajnert MF, et al. Functional differences between hepcidin 1 and 2 in transgenic mice. Blood 2004;103:2816-21.
21. Skow LC, Burkhart BA, Johnson FM, Popp RA, Popp DM, Goldberg SZ, et al. A mouse model of β-thalassemia. Cell 1983;34:1043-52.
22. Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 2005;106:1864-6.
23. Aggeli C, Antoniades C, Cosma C, Chrysohoou C, Tousoulis D, Ladis V, et al. Endothelial dysfunction and inflammatory process in transfusion-dependent patients with β-thalassemia major. Intern J Cardiol 2005;105:80-4.
24. Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G. Dysregulated monocyte iron homeostasis and erythropoeitin formation in patients with anemia of chronic disease. Blood 2006; 107:4142-8.
25. Krijt J, Vokurka M, Chang KT, Necas E. Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood 2004;104:4308-10.
26. Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 2005;106:2884-9.