Developmental cell death in the liver and newborn lethality of Ku86 deficient mice suppressed by antioxidant N-acetyl-cysteine

DNA Repair

Volumn 5, Issue 11, 2006, Pages 1392-1397

  Reliene, Ramune ^a,b   Goad, Marry E P ^c   Schiestl, Robert H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Peptimmune Inc   (United States)

Author keywords

Apoptosis; Fetal liver; Ku86; Mouse; N Acetyl cysteine; Necrosis; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; DOUBLE STRANDED DNA; KU ANTIGEN; PROTEIN KU 86; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPSY; CANNIBALISM; CELL DEATH; CELL SURVIVAL; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; FEMALE; FETUS LIVER; GENOME; HETEROZYGOSITY; HISTOPATHOLOGY; LIVER INJURY; LIVER NECROSIS; MALE; MOUSE; NEWBORN; NEWBORN DEATH; NONHUMAN; OXIDATIVE STRESS; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN DEFICIENCY; STATISTICAL SIGNIFICANCE;

ACETYLCYSTEINE; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, NUCLEAR; APOPTOSIS; DNA DEGRADATION, NECROTIC; DNA REPAIR; DNA-BINDING PROTEINS; FREE RADICAL SCAVENGERS; GENES, LETHAL; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORTALITY; OXIDATIVE STRESS;

ANIMALIA;

EID: 33749991881     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2006.06.007     Document Type: Article

References (33)

1. Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 411 (2001) 366-374
2. van Gent D.C., Hoeijmakers J.H., and Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2 (2001) 196-206
3. Collis S.J., DeWeese T.L., Jeggo P.A., and Parker A.R. The life and death of DNA-PK. Oncogene 24 (2005) 949-961
4. Khanna K.K., and Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27 (2001) 247-254
5. Lees-Miller S.P., and Meek K. Repair of DNA double strand breaks by non-homologous end joining. Biochimie 85 (2003) 1161-1173
6. Hefferin M.L., and Tomkinson A.E. Mechanism of DNA double-strand break repair by non-homologous end joining. DNA Rep. (Amst.) 4 (2005) 639-648
7. Tuteja R., and Tuteja Ku N. Autoantigen: a multifunctional DNA-binding protein. Crit. Rev. Biochem. Mol. Biol. 35 (2000) 1-33
8. Gullo C., Au M., Feng G., and Teoh G. The biology of Ku and its potential oncogenic role in cancer. Biochim. Biophys. Acta (2006)
9. Reliene R., Bishop A.J., Li G., and Schiestl R.H. Ku86 deficiency leads to reduced intrachromosomal homologous recombination in vivo in mice. DNA Rep. (Amst.) 3 (2004) 103-111
10. Featherstone C., and Jackson Ku S.P. a DNA repair protein with multiple cellular functions?. Mutat. Res. 434 (1999) 3-15
11. Nussenzweig A., Chen C., da Costa Soares V., Sanchez M., Sokol K., Nussenzweig M.C., and Li G.C. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382 (1996) 551-555
12. Gu Y., Sekiguchi J., Gao Y., Dikkes P., Frank K., Ferguson D., Hasty P., Chun J., and Alt F.W. Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 2668-2673
13. Karanjawala Z.E., Murphy N., Hinton D.R., Hsieh C.L., and Lieber M.R. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr. Biol. 12 (2002) 397-402
14. -/- mice. DNA Rep. (Amst.) 2 (2003) 1429-1434
15. Nussenzweig A., Sokol K., Burgman P., Li L., and Li G.C. Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 13588-13593
16. Vogel H., Lim D.S., Karsenty G., Finegold M., and Hasty P. Deletion of Ku86 causes early onset of senescence in mice. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 10770-10775
17. Narasimhaiah R., Tuchman A., Lin S.L., and Naegele J.R. Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice. Cereb. Cortex 15 (2005) 696-707
18. De Flora S., Izzotti A., D'Agostini F., and Balansky R.M. Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis 22 (2001) 999-1013
19. Izzotti A., Balansky R.M., Cartiglia C., Camoirano A., Longobardi M., and De Flora S. Genomic and transcriptional alterations in mouse fetus liver after transplacental exposure to cigarette smoke. FASEB J 17 (2003) 1127-1129
20. Reliene R., Fischer E., and Schiestl R.H. Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice. Cancer Res. 64 (2004) 5148-5153
21. Assuncao Guimaraes C., and Linden R. Programmed cell deaths. Apoptosis and alternative deathstyles. Eur. J. Biochem. 271 (2004) 1638-1650
22. Leist M., and Nicotera P. The shape of cell death. Biochem. Biophys. Res. Commun. 236 (1997) 1-9
23. Kuby J. Immunology (1997), W.H. Freeman Company
24. Houssaint E. Differentiation of the mouse hepatic primordium. II. Extrinsic origin of the haemopoietic cell line. Cell Differ. 10 (1981) 243-252
25. Dzierzak E., Medvinsky A., and de Bruijn M. Qualitative and quantitative aspects of haematopoietic cell development in the mammalian embryo. Immunol. Today 19 (1998) 228-236
26. Miyajima A., Kinoshita T., Tanaka M., Kamiya A., Mukouyama Y., and Hara T. Role of oncostatin M in hematopoiesis and liver development. Cytok. Growth Factor Rev. 11 (2000) 177-183
27. Kanamura S., Kanai K., and Watanabe J. Fine structure and function of hepatocytes during development. J. Electron. Microsc. Tech. 14 (1990) 92-105
28. Friedberg E.C., Walker G.C., and Siede W. DNA Repair and Mutagenesis (1995), American Society for Microbiology, Washington, DC
29. Reliene R., and Schiestl R.H. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis 27 (2006) 240-244
30. Maki R., Kearney J., Paige C., and Tonegawa S. Immunoglobulin gene rearrangement in immature B cells. Science 209 (1980) 1366-1369
31. Alt F., Rosenberg N., Lewis S., Thomas E., and Baltimore D. Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell 27 (1981) 381-390
32. Strasser A., Rolink A., and Melchers F. One synchronous wave of B cell development in mouse fetal liver changes at day 16 of gestation from dependence to independence of a stromal cell environment. J. Exp. Med. 170 (1989) 1973-1986
33. Schlissel M.S., and Morrow Ig T. Heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination. J. Immunol. 153 (1994) 1645-1657