The spontaneously hypertensive rat: An experimental model of sulfur dioxide-induced airways disease

Toxicological Sciences

Volumn 94, Issue 1, 2006, Pages 193-205

  Kodavanti, Urmila P ^a   Schladweiler, Mette C ^a   Ledbetter, Allen D ^a   Ortuno, Roselia Villalobos ^b   Suffia, Marie ^b   Evansky, Paul ^a   Richards, Judy H ^a   Jaskot, Richard H ^a   Thomas, Ronald ^a   Karoly, Edward ^a   Huang, Yuh Chin T ^a   Costa, Daniel L ^a   Gilmour, Peter S ^c   Pinkerton, Kent E ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Bronchitis; Chronic obstructive pulmonary disease; Inflammation; Mucus hypersecretion; Spontaneously hypertensive rats; Sulfur dioxide exposure

Indexed keywords

ACETYLGLUCOSAMINIDASE; LACTATE DEHYDROGENASE; MUCIN; SULFUR DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING PATTERN; BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; FATTY ACID METABOLISM; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION; HYPERCOAGULABILITY; IMMUNE DEFICIENCY; IMMUNE DYSREGULATION; INFLAMMATORY DISEASE; LUNG LAVAGE; MALE; MORPHOMETRICS; NEUTROPHIL COUNT; NONHUMAN; OXIDATIVE STRESS; PHENOTYPIC VARIATION; PROTEIN SECRETION; RAT; RESPIRATORY TRACT INJURY; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT;

ACETYLGLUCOSAMINIDASE; ADMINISTRATION, INHALATION; ANIMALS; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL2; CHEMOKINES, CXC; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; L-LACTATE DEHYDROGENASE; MALE; MUCUS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; RESPIRATORY MECHANICS; RNA, MESSENGER; SPECIES SPECIFICITY; SULFUR DIOXIDE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

RODENTIA;

EID: 33749597735     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl087     Document Type: Article

References (57)

1. Aharinejad, S., Schraufnagel, D. E., Bock, P., MacKay, C. A., Larson, E. K., Milksovsky, A., and Marks, S. C., Jr. (1996). Spontaneously hypertensive rats develop pulmonary hypertension and hypertrophy of pulmonary venous sphincters. Am. J. Pathol. 148, 281-290.
2. Amagasa, H., Okazaki, M., Iwai, T., Kobayashi, S., and Oguchi, K. (2005). Enhancement of the coagulation system in spontaneously hypertensive and hyperlipidemic rats. J. Atheroscler. Thromb. 12, 191-198.
3. Barnes, P. J. (1999). Molecular genetics of chronic obstructive pulmonary disease. Thorax 54, 245-252.
4. Cawston, T., Carrere, S., Catterall, J., Duggleby, R., Elliott, S., Shingleton, B., and Rowan, A. (2001). Matrix metalloproteinases and TIMPs: Properties and implications for the treatment of chronic obstructive pulmonary disease. Novartis Found. Symp. 234, 205-218.
5. Chung, K. F. (2001). Cytokines in chronic obstructive pulmonary disease. Eur. Respir. J. Suppl. 34, 50s-59s.
6. Costa, D. L., Lehmann, J. R., Slatkin, D. N., Popenoe, E. A., and Drew, R. T. (1983). Chronic airway obstruction and bronchiectasis in the rat after intratracheal bleomycin. Lung 161, 287-300.
7. Debreczeni, L. A., Vertes, K., Barat, E., and Huszar, E. (1989). Breathing pattern of spontaneously hypertensive rats. Acta Physiol. Hung. 74, 33-36.
8. Drew, R. T., Kutzman, R. S., Costa, D. L., and Iwai, J. (1983). Effects of sulfur dioxide and ozone on hypertension sensitive and resistant rats. Fundam. Appl. Toxicol. 3, 298-302.
9. Foronjy, R. F., Mirochnitchenko, O., Propokenko, O., Lemaitre, V., Jia, Y., Inouye, M., Okada, Y., and D'Armiento, J. M. (2006). Superoxide dismutase expression attenuates cigarette smoke- or elastase-generated emphysema in mice. Am. J. Respir. Crit. Care Med. 173, 623-631.
10. Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge,Y., Gentry, J., et al. (2004). Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol. 5, R80:1-R80:16.
11. Gilmour, P. S., Schladweiler, M. C., Nyska, A., McGee, J. K., Thomas, R., Jaskot, J. H., Schmid, J., and Kodavanti, U. P. (2006). Systemic imbalance of essential metals and cardiac gene expression in rats following acute pulmonary zinc exposure. J. Toxicol. Environ. Health Part A 69, 2011-2032.
12. Grootendorst, D. C., and Rabe, K. F. (2004). Mechanism of bronchial hyperreactivity in asthma and chronic obstructive pulmonary diseases. Proc. Am. Thorac. Soc. 1, 77-87.
13. Gu, J., Spitz, M. R., Zhao, H., Lin, J., Grossman, H. B., Dinney, C. P., and Wu, X. (2005). Roles of tumor suppressor and telomere maintenance genes in cancer and aging - an epidemiological study. Carcinogenesis 26, 1741-1747.
14. Guerassimov, A., Hoshino, Y., Takubo, Y., Turkotte, A., Yamamoto, M., Ghezzo, H., Triantafillopoulos, A., Whittaker, K., Hoidal, J. R., Casio, M. G. (2004). The development of emphysema in cigarette smoke-exposed mice is strain dependent. Am. J. Respir. Crit. Care Med. 170, 974-980.
15. Gumuslu, S., Bilmen, S., Korgun, D. K., Yargicoglu, P., and Agar, A. (2001). Age-related changes in antioxidant enzyme activities and lipid peroxidation in lungs of control and sulfur dioxide exposed rats. Free Radic. Res. 34, 621-627.
16. Hajri, T., Ibrahimi, A., Coburn, C. T., Knapp, F. F., Jr, Kurtz, T., Pravenec, M., and Abumrad, N. A. (2001). Defective fatty acid uptake in the spontaneously hypertensive rat is a primary determinant of altered glucose metabolism, hyperinsulinamia, and myocardial hypertrophy. J. Biol. Chem. 276, 23661-23666.
17. Irizarry, R. A., Hobbs, B., Collin, F., Beazer-Barclay, Y. D., Antonellis, K. J., Scherf, U., and Speed, T. P. (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4, 249-264.
18. Khraibi, A. A., Norman, R. A., Jr, and Dzielak, D. J. (1984). Chronic immunosuppression attenuates hypertension in Okamoto spontaneously hypertensive rats. Am. J. Physiol. 247, H722-H726.
19. Killingsworth, C. R., Paulauskis, J. D., and shore, S. A. (1996). Substance P content and preprotachykinin gene-I mRNA expression in a rat model of chronic bronchitis. Am. J. Respir. Cell Mol. Biol. 14, 334-340.
20. Knauss, H. J., Medici, T. C., and Chodosh, S. (1976). Cell vs. noncell airway temporal responses in rats exposed to sulfur dioxide. Arch. Environ. Health 31, 241-247.
21. Kobayashi, N., DeLano, F. A., and Schmid-Schonbein, G.W. (2005). Oxidative stress promotes endothelial cell apoptosis and loss of microvessels in the spontaneously hypertensive rats. Arterioscler. Thromb. Vasc. Biol. 25, 2114-2121.
22. Kodavanti, U. P., and Costa, D. L. (2001). Rodent models of susceptibility: What is their place in inhalation toxicology? Respir. Physiol. 128, 57-70.
23. Kodavanti, U. P., Costa, D. L., and Bromberg, P. (1998). Rodent models of cardiopulmonary disease: Their potential applicability in studies of air pollutant susceptibility. Environ. Health Perspect. 106(Suppl. 1), 111-130.
24. Kodavanti, U. P., Jackson, M. C., Ledbetter, A. D., Starcher, B. C., Evansky, P. A., Harwood, A., Winsett, D. W., and Costa, D. L. (2000a). The combination of elastase and sulfur dioxide exposure causes COPD-like lesions in the rat. Chest 117, 299S-302S.
25. Kodavanti, U. P., Mebane, R., Ledbetter, A., Krantz, T., McGee, J., Jackson, M. C., Walsh, L., Hilliard, H., Chen, B. Y., Richards, J., et al. (2000b). Variable pulmonary responses from exposure to concentrated ambient air particles in a rat model of bronchitis. Toxicol. Sci. 54, 441-451.
26. Kodavanti, U. P., Schladweiler, M. C. J., Ledbetter, A. D., Watkinson, W. P., Campen, M. J., Winsett, D. W., Richards, J. R., Crissman, K. M., Hatch, G. E., and Costa, D. L. (2000c). The spontaneously hypertensive rat as a model of human cardiovascular disease: Evidence of exacerbated cardio-pulmonary injury and oxidative stress from inhaled emission particulate matter. Toxicol. Appl. Pharmacol. 164, 250-263.
27. Kodavanti, U. P., Schladweiler, M. C. J., Ledbetter, A. D., Hauser, R., Christiani, D. C., McGee, J., Richards, J. R., and Costa, D. L. (2002). Temporal association between pulmonary and systemic effects of particulate matter in healthy and cardiovascular compromised rats. J. Toxicol. Environ. Health A 65, 1545-1569.
28. Kodavanti, U. P., Schladweiler, M. C. J., Ledbetter, A. D., McGee, J. K., Walsh, L., Gilmour, P. S., Highfill, J. W., Davies, D., Pinkerton, K. E., Richards, J. H., et al. (2005). Consistent pulmonary and systemic responses from inhalation of fine concentrated ambient particles: Roles of rat strains used and physicochemical properties. Environ. Health Perspect. 113, 1561-1568.
29. Lamb, D., and Reid, L. (1968). Mitotic rates, goblet cell increase and histochemical changes in mucus in rat bronchial epithelium during exposure to sulphur dioxide. J. Pathol. Bacteriol. 96, 97-111.
30. Lazaro, A., Gallego-Delgado, J., Justo, P., Esteban, V., Osende, J., Mezzano, S., Ortiz, A., and Egido, J. (2005). Long-term blood pressure control prevents oxidative renal injury. Antioxid. Redox. Signal 7, 1285-1293.
31. Leong, L. Y., Le Rolle, A. F., Deverson, E. V., Powis, S. J., Larkins, A. P., Vaage, J. T., Stokland, A., Lambracht-Washington, D., Rolstad, B., Joly, E., et al. (1999). RT1-U: Identification of a novel, active, class Ib alloantigen of the rat MHC. J. Immunol. 162, 743-752.
32. Lombet, A., Planque, N., Bleau, A. M., Li, C. L., and Perbal, B. (2003). CCN3 and calcium signaling. Cell Commun. Signal 1, 1-10.
33. Long, N. C., Abraham, J., Kobzik, L.,Weller, E. A., Krishna Murthy, G. G., and Shore, S. A. (1999). Respiratory tract inflammation during the induction of chronic bronchitis in rats: Role of C fibers. Eur. Respir. J. 14, 46-56.
34. Long, N. C., Martin, J. G., Pantano, R., and Shore S. A. (1997). Airway hyperresponsiveness in a rat model of chronic bronchitis: Role of C fibers. Am. J. Respir. Crit. Care Med. 155, 1222-1229.
35. MacNee, W. (2005). Pathogenesis of chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2, 258-266.
36. Matsushita, I., Hasegawa, K., Nakata, K., Yasuda, K., Tokunaga, K., and Keicho, N. (2002). Genetic variants of human beta-defensin-1 and chronic obstructive pulmonary disease. Biochem. Biophys. Res. Commun. 291, 17-22.
37. Meng, Z. (2003). Oxidative damage of sulfur dioxide on various organs of mice: Sulfur dioxide is a systemic oxidative damage agent. Inhal. Toxicol. 15, 181-195.
38. Meng, Z., Liu, Y., and Wu, D. (2005). Effect of sulfur dioxide inhalation on cytokine levels in lungs and serum of mice. Inhal. Toxicol. 17, 303-307.
39. Petering, D. H., and Shih, N. T. (1975). Biochemistry of bisulfite-sulfur dioxide. Environ. Res. 9, 55-65.
40. Pons, A. R., Noguera, A., Blanquer, D., Sauleda, J., Pons, J., and Agusti, A. G. (2005). Phenotypic characterization of alveolar macrophages and peripheral blood monocytes in COPD. Eur. Respir. J. 25, 647-652.
41. Postma, D. S., and Timens, W. (2006). Remodeling in asthma and chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 3, 434-439.
42. Pravenec, M., and Kurtz, T. W. (2002). Genetics of CD36 and the hypertension metabolic syndrome. Semin. Nephrol. 22, 148-153.
43. Pravenec, M., Landa, V., Zidek, V., Musilova, A., Kazdova, L., Qi, N.,Wand, J., St Lezin, E., and Kurtz, T. W. (2003). Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but no effect on hypertension. Physiol. Res. 52, 681-688.
44. Pravenec, M., Zidek, V., Landa, V., Simakova, M., Mlejnek, P., Kazdova, L., Bila, V., Krenova, D., and Kren, V. (2004). Genetic analysis of "metabolic syndrome" in the spontaneously hypertensive rat. Physiol. Res. 53, S15-S22.
45. Rennard, S. I. (2005). Clinical approach to patients with chronic obstructive pulmonary disease and cardiovascular disease. Proc. Am. Thorac. Soc. 2, 94-100.
46. Rodriguez-Iturbe, B., Zhan, C. D., Quiroz, Y., Sindhu, R. K., and Vaziri, N. D. (2003). Antioxidant-rich diet relieves hypertension and reduces renal immune infiltration in spontaneously hypertensive rats. Hypertension 41, 341-346.
47. Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003). TM4: A free, opensource system for microarray data management and analysis. Biotechniques 34, 374-378.
48. Sandford, A. J., Joos, L., and Pare, P. D. (2002). Genetic risk factors for chronic obstructive pulmonary disease. Curr. Opin. Pulm. Med. 8, 87-94.
49. Schmid-Schonbein, G. W., Seiffge, D., DeLano, F. A., et al. (1991). Leukocyte counts and activation in spontaneously hypertensive and normotensive rats. Hypertension 17, 323-330.
50. Shapiro, S. D. (2000). Animal models for chronic obstructive pulmonary disease. Age of Klotho and Malboro mice. Am. J. Respir. Cell Mol. Biol. 22, 4-7.
51. Shore, S. A., Kariya, S. T., Anderson, K., Skornik, W., Felman, H. A., Pennington, J., Godleski, J., and Drazen, J. M. (1987). Sulfur-dioxide-induced bronchitis in dogs. Effects on airway responsiveness to inhaled and intravenously administered methacholine. Am. Rev. Respir. Dis. 135, 840-847.
52. Shore, S., Kobzik, L., Long, N. C., Skornik, W., Van Staden, C. J., Boulet, L., Rodger, I. W., and Pon, D. J. (1995). Increased airway responsiveness to inhaled methacholine in a rat model of chronic bronchitis. Am. J. Respir. Crit. Care Med. 151, 1931-1938.
53. Siafakas, N. M., and Tzortzaki, E. G. (2002). Few smokers develop COPD. Why? Respir. Med. 96, 615-624.
54. Spurzem, J. R., and Rennard, S. I. (2005). Pathogenesis of COPD. Semin. Respir. Crit. Care Med. 26, 142-153.
55. Stites, S. W., Walters, B., O'Brien-Ladner, A. R., Bailey, K., and Wesselius, L. J. (1998). Increased iron and ferritin content of sputum from patients with cystic fibrosis or chronic bronchitis. Chest 114, 814-819.
56. Tankersley, C. G., Fitzgerald, R. S., Levitt, R. C., Mitzner, W. A., Evart, S. L., and Kleeberger, S. R. (1997). Genetic control of differential baseline breathing pattern. J. Appl. Physiol. 82, 874-881.
57. Vlahos, R., Bozinovski, S., Gualano, R. C., Ernst, M., and Anderson, G. P. (2006). Modeling COPD in mice. Pulm. Pharmacol. Ther. 19, 12-17.