Identification of exposure pathways for opioid narcotic analgesics in pharmaceutical production workers

Annals of Occupational Hygiene

Volumn 50, Issue 7, 2006, Pages 665-677

  Van Nimmen, N F J ^a   Poels, K L C ^a   Veulemans, H A F ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Active pharmaceutical ingredients (APIs); Biological monitoring; Dermal; Fentanyl; Inhalation; Production workers

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS (API); BIOLOGICAL MONITORING; DERMAL; FENTANYL; PRODUCTION WORKERS;

CONTAMINATION; DRUG PRODUCTS PLANTS; HEALTH RISKS; MATHEMATICAL MODELS;

DRUG PRODUCTS;

FENTANYL; NARCOTIC ANALGESIC AGENT; OPIATE;

ADULT; AIR SAMPLING; ARTICLE; BIOLOGICAL MONITORING; CONTAMINATION; CORRELATION ANALYSIS; DRUG MANUFACTURE; ENVIRONMENTAL EXPOSURE; HUMAN; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL EXPOSURE; POLLUTION MONITORING; PRIORITY JOURNAL; PROTECTION; RISK ASSESSMENT; SKIN ABSORPTION; URINALYSIS; WORKER;

ANALGESICS, OPIOID; DRUG INDUSTRY; ENVIRONMENTAL MONITORING; FENTANYL; HUMANS; INHALATION EXPOSURE; MALE; OCCUPATIONAL EXPOSURE; SKIN ABSORPTION;

EID: 33749582011     PISSN: 00034878     EISSN: 14753162     Source Type: Journal    
DOI: 10.1093/annhyg/mel028     Document Type: Article

References (22)

1. Berner B, John V. (1994) Pharmacokinetic characterisation of transdermal delivery systems. Clin Pharmacokinet; 26(2): 121-34.
2. Binks SP. (2003) Occupational toxicology and the control of exposure to pharmaceutical agents at work. Occup Med (Lond); 53(6): 363-70.
3. Bos PM, Brouwer DH, Stevenson H et al. (1998) Proposal for the assessment of quantitative dermal exposure limits in occupational environments: part 1. Development of a concept to derive a quantitative dermal occupational exposure limit. Occup Environ Med; 55: 795-804.
4. CEN (Centre Européen de Normalisation). (2005) Workplace exposure-Measurments of dermal exposure-Principles and methods. PrCEN/TS 15279. CEN/TC 137/WG6. Sent for formal vote on March 15, 2005.
5. DeLuca R. (2004) Monograph and occupational exposure limit for fentanyl, fentanyl citrate and fentanyl hydrochloride. Corporate Johnson & Johnson documents.
6. EPA (U.S. Environmental Protection Agency). (1989) Exposure factors handbook. Washington, DC: Office of Health and Environmental Assessment, Exposure Assessment Group. EPA/600/8-89/043, PB90-106774.
7. Grond S, Radbruch L, Lehmann KA. (2000) Clinical pharmacokinetics of transdermal opioids. Focus on transdermal fentanyl. Clin Pharmacokinet; 38(1): 59-89.
8. Kenny Aitken R, Chalmers C, Fabries JF et al. (1997) A collaborative European study of personal inhalable aerosol sampler performance. Ann Occup Hyg; 41: 135-53.
9. Ku RH. (2000) An overview of setting occupational exposure limits (OELs) for pharmaceuticals. Chemical Health & Safety; January/February: 34-7.
10. Mather LE. (1983) Clinical pharmacokinetics of fentanyl and its newer derivatives. Clin Pharmacokinet; 8: 422-46.
11. McClain DA, Hug CC. (1980) Intraveneous fentanyl kinetics. Clin Pharmacol. Ther; 28: 106-14.
12. McClean MD, Rinehart RD, Ngo L, Eisen EA, Kelsey KT, Herrick RF. (2004) Inhalation and dermal exposure among asphalt paving workers. Ann Occup Hyg; 48(8): 663-71.
13. Morgan MS. (1997) The biological exposure indices: a key component in protecting workers from toxic chemicals. Environ Health Persp; 105(S1): 105-15.
14. Naumann BD, Sargent EV, Starkman BS et al. (1996) Performance-based exposure control limits for pharmaceutical active ingredients. Am Ind Hyg Assoc J; 57: 33-42.
15. Schneider T, Vermeulen R, Brouwer D et al. (1999) A conceptual model for assessment of dermal exposure. Occup Environ Med; 56: 765-73.
16. Scholz J, Steinfath M, Schulz M. (1996) Clinical pharmacokinetics of alfentanil, fentanyl and sufentanil-an update. Clin Pharmacokinet; 31(4): 275-92.
17. Sessink PJ, Timmermans JL, Anzion RB et al. (1994a) Assessment of occupational exposure of pharmaceutical plant workers to 5-fluorouracil. Determination of α-fluoro-β-alanine in urine. J Occup Med; 36(1): 79-83.
18. Sessink PJ, Friemèl NS, Anzion RB et al. (1994b) Biological and environmental monitoring of occupational exposure of pharmaceutical plant workers to methotrexate. Int Arch Occup Environ Health; 65(6): 401-3.
19. Van Nimmen NF, Veulemans HA. (2004). Development and validation of a highly sensitive gas chromatographic-mass spectrometric screening method for the simultaneous determination of nanogram levels of fentanyl, sufentanil and alfentanil in air and surface contamination wipes. J. Chromatogr A; 1035: 249-59.
20. Van Nimmen NF, Poels KL, Veulemans HA. (2004) A highly sensitive gas chromatographic-mass spectrometric screening method for the determination of picogram levels of fentanyl, sufentanil and alfentanil and their major metabolites in urine of opioid exposed workers. J Chromatogr B; 804: 375-87.
21. Vincent JH. (1999) Particle size-selective sampling for particulate air contaminants. Cincinnati, OH: ACGIH, p. 130.
22. Willens JS, Myslinski NR. (1993) Pharmacodynamics, pharmacokinetics and clinical uses of fentanyl, sufentanil and alfentanil. Heart & Lung; 22(3): 239-51.