Proposal for the assessment of quantitative dermal exposure limits in occupational environments: Part 1. Development of a concept to derive a quantitative dermal occupational exposure limit

Occupational and Environmental Medicine

Volumn 55, Issue 12, 1998, Pages 795-804

  Bos, P M J ^a   Brouwer, D H ^a   Stevenson, H ^a   Boogaard, P J ^b   De Kort, W L A M ^a   Van Hemmen, J J ^a  

^a TNO   (Netherlands)

^b SHELL RESEARCH AND TECHNOLOGY CENTRE   (Netherlands)

Author keywords

Dermal exposure; Industrial hygiene; Occupational exposure limits

Indexed keywords

4,4' METHYLENEDIANILINE; CYCLOPHOSPHAMIDE;

ARTICLE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; HUMAN; MAXIMUM PERMISSIBLE DOSE; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; SCORING SYSTEM; SKIN ABSORPTION; SKIN PENETRATION; SKIN SURFACE;

EID: 0031729068     PISSN: 13510711     EISSN: None     Source Type: Journal    
DOI: 10.1136/oem.55.12.795     Document Type: Article

References (48)

1. American Conference of Governmental Industrial Hygienists (ACGIH). Documentation of the threshold limit values and biological exposure indices, 6th ed. Cincinnati, USA: ACGIH, 1991.
2. Greim H, Lehnert G, eds. Biologische Arbeitsstoff-Toleranz-Werte (BAT-Werte) und Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA). Weinheim, Germany: VCH Verlagsgesellschaft mbH, 1996.
3. Wilson HK. Recent policy and technical developments in biological monitoring in the United Kingdom. Sci Total Environ 1997;199:191-6.
4. Aitio A., Pekari K, Järvisalo J. Skin absorption as a source of error in biological monitoring. Scand J Work Environ Health 1984;10:317-20.
5. Kao J, Carver MP. Cutaneous metabolism of xenobiotics. Drug Metab Rev 1990;22:363-410.
6. Paustenbach DJ. Assessment of the developmental risks resulting from occupational exposure to select glycol ethers within the semiconductor industry. J Toxicol Environ Health 1988;23:29-75.
7. Grandjean P, Berlin A, Gilbert M, et al. Preventing percutaneous absorption of industrial chemicals: the skin denotation. Am J Ind Med 1988;14:97-107.
8. Scansetti G, Piolatto G, Rubino G. Skin notation in the context of workplace exposure standards. Am J Ind Med 1988;14:725-32.
9. European Centre for Ecotoxicology and Toxicology of Chemicals. Strategy for assigning a skin notation. Brussels: ECETOC, 1993 (Revised ECETOC Document No 31.)
10. Fenske R, Van Hemmen, JJ. Occupational skin exposure to chemical substances: setting limits [editorial]. Ann Occup Hyg 1994;38:333-6.
11. Dost AA. Meeting report. A European meeting held to discuss dermal exposure monitoring and related issues. Brussels: 21-23 June 1994. Ann Occup Hyg 1995;39:241-55.
12. Brouwer D, Hoogendoorn L, Bos PMJ, et al. Proposal for the assessment of quantitative dermal exposure limits in the occupational environment. Part II. Feasibility study for application in an exposure scenario for MDA by two different dermal exposure sampling methods. Occup Environ Med 1997,55:000-000.
13. Fiserova-Bergerova V, Pierce JT, Droz PO. Dermal absorption potential of industrial chemicals: criteria for skin notation. Am J Ind Med 1990;17:617-35.
14. Fiserova-Bergerova V. Relevance of occupational skin exposure. Ann Occup Hyg 1993;37:673-85.
15. Environmental Protection Agency. Dermal exposure assessment: Principles and applications [interim report]. Washington, DC: US Environmental Protection Agency, 1992.
16. Kežić S, Mahieu K, Monster AC, et al. Dermal absorption of vaporous and liquid 2-methoxyethanol and 2-ethoxyethanol in volunteers. Occup Environ Med 1997;54: 38-43.
17. Johanson G, Boman A. Percutaneous absorption of 2-butoxyethanol vapour in human subjects. Br J Ind Med 1991;48:788-92.
18. European Centre for Ecotoxicology and Toxicology of Chemicals. Percutaneous absorption. Brussels: ECETOC, 1993:1-80. (Monograph No 20.)
19. Stevenson H, Opdam JJG, Van Ommen B, et al. Protocol for the estimation of dermal absorption according to a tiered approach on behalf of the risk assessment of pesticides. Zeist, The Netherlands: TNO, 1994. (TNO-report V94.129.)
20. Bronaugh RL, Barton CN. Prediction of human percutaneous absorption with physicochemical data. In: Wang RGM, Knaak JB, Maibach HI, eds. Health risk assessment. Dermal and inhalation exposure and absorption of toxicants. Boca Raton, USA: CRC Press, 1993.
21. Bos PMJ. Testing the possibility for the assessment of a dermal occupational exposure limit: a case study. Cyclophosphamide. Zeist, The Netherlands: TNO Food and Nutrition Research, 1994. (In Dutch.)
22. Fenske R. Dermal exposure assessment techniques. Ann Occup Hyg 1993;37:687-706.
23. Cherrie, JW, Robertson A. Biologically relevant assessment of dermal exposure. Ann Occup Hyg 1995;39:387-92.
24. Hotchkiss SAM. Skin absorption of occupational chemicals. In: Handbook of occupational hygiene. Kingston upon Thames, UK: Groner, 1993.
25. Chester G. Revised guidance document for the conduct of field studies of exposure to pesticides in use. In: Curry PB, Iyengar S, Maloney P, Maroni M, eds. Methods of pesticide exposure assessment. London: Plenum Press, 1995.
26. Van Hemmen JJ, Van Golstein Brouwers YGC, Brouwer DH. Pesticide exposure and re-entry in agriculture. In: Curry PB, Iyengar S, Maloney PA, Maroni M, eds. Methods of pesticide exposure assessment. London: Plenum Press, 1995.
27. De Raat WK, Krüse J, Stevenson H, et al. Outline of a protocol for dermal-to-dermal extrapolation. TNO-report V97.972, Zeist, The Netherlands: 1997. (TNO-report V97.972.)
28. Hakkert BC, Stevenson H, Bos PMJ, et al. Methods for the establishment of health-based recommended occupational exposure limits for existing substances. Zeist, The Netherlands: 1996. (TNO-report V96.463.)
29. Wester RC, Maibach HI, Cutaneous pharmacokinetics: 10 steps to percutaneous absorption. Drug Metab Rev 1983;14:169-205.
30. Grandjean P. Skin penetration: Hazardous chemicals at work. London: Taylor and Francis, 1990.
31. Paustenbach DJ, Leung H-W. Techniques for assessing the health risks of dermal contact with chemicals in the environment. In: Wang RGM, Knaak JB, Maibach HI, eds. Health risk assessment. Dermal and inhalation exposure and absorption of toxicants. Boca Raton, USA: CRC Press, 1993.
32. De Carvalho M, Falson-Rieg F, Eynard I, et al. Changes in vehicle composition during skin permeation studies. In: Brain KR, James VJ, Walters KA, eds. Prediction of percutaneous penetration. Vol 3b. Cardiff, UK: STS Publishing, 1993:251-54.
33. Boogaard PJ, Van der Waal H. Biological monitoring of dermal exposure to 4,4′-diaminodiphenyl methane (MDA) by determination of MDA in hydrolysed urine- a human volunteer study. Shell Biomedical Laboratory, preliminary internal report. Rotterdam, The Netherlands: Shell Biomedical Laboratory, 1994.
34. Brunmark P. Methods for assessment of exposure to aromatic amines and isocyanates by air monitoring and biomarkers [doctoral dissertation]. Lund, Sweden: University of Lund, 1994.
35. Kompaore F, Tsuruta H. In vivo differences between Asian, black, and white in the stratum corneum barrier function. Int Arch Occup Environ Health 1993;65:S223-5.
36. Leung H-W, Paustenbach DJ. Techniques for estimating the percutaneous absorption of chemicals due to occupational and environmental exposure. Appl Occup Environ Hyg 1994;9:187-97.
37. Wilschut A, Ten Berge WF, Robinson PJ, et al. Estimating skin permeation. The validation of five mathematical skin permeation models. Chemosphere 1995;30:1275-96.
38. Boogaard PJ. Testing the possibility for the assessment of a dermal occupational exposure limit: a case study. 4,4′-methylene dianiline. Den Haag, The Netherlands: Shell Internationale Petroleum Maatschappij B, 1994. (Unpublished report, in Dutch.)
39. Health Council of the Netherlands: Dutch Expert Committee on Occupational Standards (DECOS): Calculating cancer risk. The Hague: Health Council of the Netherlands, 1995. (Publication No 1995/06WGD.)
40. Schmähl D, Habs M. Carcinogenic action of low-dose cyclophosphamide given orally to Sprague-Dawley rats in a lifetime experiment. Int J Cancer 1979;23:706-12.
41. Hirst M, Tse S, Mills DG, et al. Occupational exposure to cyclophosphamide. Lancet 1984;i:186-8.
42. Mouridsen HT, Faber O, Skovsted L. The biotransformation of cyclophosphamide in man: analysis of the variation in normal subjects. Acta Pharmacol 1974;35:98-106.
43. Mouridsen HT, Faber O, Skovsted L. The metabolism of cyclophosphamide. Dose dependency and the effect of long-term treatment with cyclophosphamide. Cancer 1976; 37:665-70.
44. Sessink PJM, Van den Broek PHH, Bos RP. Urinary cyclophosphamide excretion in rats after intra tracheal, dermal, oral, and intravenous administration of cyclophosphamide. J Appl Toxicol 1991;11:125-8.
45. NTP. Technical Report on the carcinogenesis studies of 4,4′-methylene dianiline dihydrochloride in F344/N rats and B6C3F, mice (drinking water studies). NTP, 1983. (Cas No 13552-44-8.)
46. Hotchkiss SAM, Hewitt P, Caldwell J. Percutaneous absorption of 4,4′-methylene-bis-(2-chloroaniline) and 4,4′-methylene dianiline through rat and human skin in vitro. Toxicology in Vitro 1993;2:141-8.
47. Boogaard PJ, Van der Waal, H. Biological monitoring of dermal exposure to 4,4′-diamino diphenylmethane (MDA) by determination of MDA in hydrolysed urine- a human volunteer study. Rotterdam, The Netherlands: Shell Biomedical Laboratory, preliminary internal report, 1994.
48. Alarie Y. Sensory irritation by airborne chemicals. Crit Rev Toxicol 1973;2:299-363.