Circulating nucleic acids in plasma/serum and tumor progression: Are apoptotic bodies involved? An experimental study in a rat cancer model

Annals of the New York Academy of Sciences

Volumn 1075, Issue , 2006, Pages 165-173

  Samos, Julia ^a   García Olmo, Dolores C ^a   Picazo, María G ^a   Rubio Vitaller, Antonio ^a   García Olmo, Damián ^b  

^a HOSPITAL GENERAL UNIVERSITARIO DE ALBACETE   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Apoptotic bodies; Circulating nucleic acids; Colon cancer; Genometastasis

Indexed keywords

DNA; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; NUCLEIC ACID; PROPIDIUM IODIDE; PROTEIN ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOTIC BODY; BLOOD LEVEL; BLOOD SAMPLING; CANCER CELL CULTURE; CANCER DIAGNOSIS; CANCER GENETICS; CANCER MODEL; CANCER STAGING; CARCINOGENESIS; CELL FREE SYSTEM; CELL ORGANELLE; CELL STRAIN; CELL STRUCTURE; CELL TRANSFORMATION; COLON CANCER; CONFERENCE PAPER; CONTROLLED STUDY; DNA TRANSFER; ENZYMATIC DEGRADATION; EXPERIMENTAL STUDY; FEMALE; FLOW CYTOMETRY; GENOMETASTASIS; HETEROTOPIC TRANSPLANTATION; HYPOTHESIS; INTERNALIZATION; MALE; METASTASIS; NONHUMAN; NUCLEIC ACID ANALYSIS; RAT; TUMOR GROWTH;

ANIMALIA;

EID: 33749562351     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1368.022     Document Type: Conference Paper

References (31)

1. GARCÍA-OLMO, D. et al. 1999. Tumour DNA circulating in the plasma might play a role in metastasis. The hypothesis of the genometastasis. Histol. Histopathol. 14: 1159-1164.
2. GARCÍA-OLMO, D. et al. 2000. Horizontal transfer of DNA and the "genometastasis hypothesis." Blood 95: 724-725.
3. GARCÍA-OLMO, D. & D.C. GARCÍA-OLMO. 2001. Functionality of circulating DNA: the hypothesis of genometastasis. Ann. N. Y. Acad. Sci. 945: 265-275.
4. WEIGELT, B. et al. 2005. Breast cancer metastasis: markers and models. Nat. Rev. Cancer 5: 591-602.
5. ANKER, P. et al. 1999. Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev. 18: 65-73.
6. KOPRESKI, M.S. et al. 2000. Somatic mutation screening: identification of individuals harbouring K-ras mutations with the use of plasma DNA. J. Nat. Cancer Inst. 92: 918-923.
7. JAHR, S. et al. 2001. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 61: 1659-1665.
8. KOPRESKI, M.S. et al. 1999. Detection of tumour messenger RNA in the serum of patients with malignant melanoma. Clin. Cancer Res. 5: 1961-1965.
9. WANG, B.G. et al. 2003. Increased plasma DNA integrity in cancer patients. Cancer Res. 63: 3966-3968.
10. SOZZI, G. et al. 2001. Analysis of circulating tumour DNA in plasma at diagnosis and during follow-up of lung cancer patients. Cancer Res. 61: 4675-4678.
11. KOPRESKI, M.S. et al. 2000. Somatic mutation screening: identification of individuals harbouring K-ras mutations with the use of plasma DNA. J. Natl. Cancer Inst. 92: 918-923.
12. LECOMTE, T. et al. 2002. Detection of free-circulating tumour-associated DNA in plasma of colorectal cancer patients and its association with prognosis. Int. J. Cancer 100: 542-548.
13. SILVA, J.M., et al. 2002. Tumour DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survival. Clin. Cancer Res. 12: 3761-3766.
14. GARCÍA-OLMO, D.C. et al. 2005. Detection of circulating tumour cells and of tumour DNA in plasma during tumour progression in rats. Cancer Lett. 217: 115-123.
15. GARCÍA-OLMO, D.C. et al. 2003. The site of injection of tumour cells in rats does not influence the subsequent distribution of metastases. Oncol. Rep. 10: 903-907.
16. PULCIANI, S. et al. 1982. Oncogenes in human tumour cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc. Natl. Acad. Sci. USA 79: 2845-2849.
17. ANKER, P. et al. 1994. Transformation of NIH/3T3 cells and SW 480 cells displaying K-ras mutation. C. R. Acad. Sci. III 317: 869-874.
18. HOLMGREN, L. et al. 1999. Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood 93: 3956-3963.
19. BERGSMEDH, A. et al. 2001. Horizontal transfer of oncogenes by uptake of apoptotic bodies. Proc. Natl. Acad. Sci. USA 98: 6407-6411.
20. CECCARINI, M. et al. 1989. Biochemical and NMR studies on structure and release conditions of RNA-containing vesicles shed by human colon adenocarcinoma cells. Int. J. Cancer 44: 714-721.
21. STROUN, M. et al. 1978. Presence of RNA in the nucleoprotein complex spontaneously released by human lymphocytes and frog auricles in culture. Cancer Res. 38: 3546-3554.
22. WIECZOREK, A.J. et al. 1985. Isolation and characterization of an RNA-proteolipid complex associated with the malignant state in humans. Proc. Natl. Acad. Sci. USA 82: 3455-3459.
23. ROSI, A. et al. 1988. RNA-lipid complexes released from the plasma membrane of human colon carcinoma cells. Cancer Lett. 39: 153-160.
24. REDDI, K.K. & J.F. HOLLAND. 1976. Elevated serum ribonuclease in patients with pancreatic cancer. Proc. Natl. Acad. Sci. USA 73: 2308-2310.
25. EL-HEFNAWY, T. et al. 2004. Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics. Clin. Chem. 50: 564-573.
26. HASSELMANN, D.O. et al. 2001. Extracellular tyrosinase mRNA within apoptotic bodies is protected from degradation in human serum. Clin. Chem. 47: 1488-1489.
27. NG, E.K. et al. 2002. Presence of filterable and nonfilterable mRNA in the plasma of cancer patients and healthy individuals. Clin. Chem. 48: 1212-1217.
28. TSUI, N.B. et al. 2002. Stability of endogenous and added RNA in blood specimens, serum, and plasma. Clin. Chem. 48: 1647-1653.
29. HALICKA, H.D. et al. 2000. Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis. Exp. Cell Res. 260: 248-256.
30. VERMES, I. et al. 2000. Flow cytometry of apoptotic cell death. J. Immunol. Meth. 243: 167-190.
31. GARCÍA-OLMO, D.C. et al. 2004. Circulating nucleic acids in plasma and serum (CNAPS) and its relation to stem cells and cancer metastasis: state of the issue. Histol. Histopathol. 19: 575-583.