Regulatory activity of activated murine peripheral CD4+CD25 - T cells: A possible mechanism of feedback regulation on adaptive immunity

Scandinavian Journal of Immunology

Volumn 64, Issue 5, 2006, Pages 500-506

  Lu, Y ^a   Xu, W ^a   Zhou, Y ^a   Lv, P ^a   Gao, X M ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 2; MONOCLONAL ANTIBODY CD3; OVALBUMIN; PROTEIN; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEEDBACK SYSTEM; FEMALE; HUMORAL IMMUNITY; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CLONE CELLS; FEEDBACK; FEMALE; IMMUNE TOLERANCE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; OVALBUMIN; PHENOTYPE;

EID: 33749551149     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2006.01842.x     Document Type: Article

References (25)

1. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunological self-tolerance maintained by activated T-cells expressing IL-2 receptor α chains (CD25) breakdown of a single mechanism of self-tolerance causes various autoimmune-diseases. J Immunol 1995;155:1151-64.
2. Asano M, Toda M, Sakaguchi N, Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 1996;184:387-96.
3. +high regulatory T cell function. J Immunol 2002;169:6210-7.
4. + suppressor T cells: more questions than answers. Nat Rev Immunol 2002;2:389-400.
5. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004;22:531-62.
6. Schwartz RH. T cell anergy. Annu Rev Immunol 2003;21:305-14.
7. Lombardi G, Sidhu S, Batchelor R, Lechler R. Anergic T cells as suppressor cells in vitro. Science 1994;264:1587-9.
8. Chai JG, Bartok I, Chandler P et al. Anergic T cells act as suppressor cells in vitro and in vivo. Eur J Immunol 1999;29:686-92.
9. Kuwana M. Induction of anergic and regulatory T cells by plasmacytoid dendritic cells and other dendritic cell subsets. Hum Immunol 2002;63:1156-63.
10. + T cells facilitate the induction of T cell anergy. J Immunol 2001;167:4271-5.
11. + T cells. J Immunol 2004;172:2238-46.
12. - T cells in aged mice are hyporesponsive and exhibit suppressive activity. J Immunol 2003;170:1675-82.
13. Zhang XY, Liu XG, Wang W, Wang WC, Gao XM. Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells. Immunology 2003;108:465-73.
14. Han SH, Li B, Chen YT, Gao XM. Isolation and functional analysis of autoreactive T cells from BXSB mice with murine lupus. J Autoimmun 2002;19:45-54.
15. Ormerod MG, Collins MK, Rodriguez-Tarduchy G, Robertson D. Apoptosis in interleukin-3-dependent haemopoietic cells. Quantifi-cation by two flow cytometric methods. J Immunol Methods 1992;153:57-65.
16. Dive C, Gregory CD, Phipps DJ, Evans DL, Milner AE, Wyllie AH. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim Biophys Acta 1992;1133:275-85.
17. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002;16:311-23.
18. + regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002;3:135-42.
19. + T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 T regulatory cells. J Exp Med 2002;196:1335-46.
20. + regulatory T cells. Nat Immunol 2003;4:330-6.
21. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003;198:1875-86.
22. - T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 2004;172:5149-53.
23. + regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J Immunol 2004;172:1531-9.
24. + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002;168:1080-6.
25. Hitoshi Y, Lorens J, Kitada S-I et al. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity 1998;8:461-71.