Plasticity of spinal cord reflexes after a complete transection in adult rats: Relationship to stepping ability

Journal of Neurophysiology

Volumn 96, Issue 4, 2006, Pages 1699-1710

  Lavrov, Igor ^a   Gerasimenko, Yury P ^a,b   Ichiyama, Ronaldo M ^a   Courtine, Gregoire ^a   Zhong, Hui ^a   Roy, Roland R ^a   Edgerton, V Reggie ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PAVLOV INSTITUTE OF PHYSIOLOGY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; LOCOMOTION; MONOSYNAPTIC REFLEX; MOTONEURON; MOTOR NERVE; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NERVE STIMULATION; NONHUMAN; POLYSYNAPTIC REFLEX; PRIORITY JOURNAL; RAT; SPINAL CORD STIMULATION; SPINAL CORD TRANSSECTION; SPINAL REFLEX;

ANIMALS; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; FEMALE; H-REFLEX; NEURONAL PLASTICITY; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SPINAL CORD; SPINAL CORD INJURIES; SYNAPSES; WALKING;

EID: 33749522237     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00325.2006     Document Type: Article

References (50)

1. 2+ exchanger. J Neurosci 16: 545-552, 1996.
2. Ashby P, Verrier M, and Lightfoot E. Segmental reflex pathways in spinal shock and spinal spasticity in man. J Neurol Neurosurg Psychiatry 37: 1352-1360, 1974.
3. Bussel B, Roby-Brami A, Yakovleff A, and Bennis N. Late flexion reflex in paraplegic patients: evidence for a spinal stepping generator. Brain Res Bull 22: 53-56, 1989.
4. Calancie B, Broton JG, Klose KJ, Traad M, Difini J, and Ayyar DR. Evidence that alterations in presynaptic inhibition contribute to segmental hypo- and hyperexcitability after spinal cord injury in man. Electroencephalogr Clin Neurophysiol 89: 177-186, 1993.
5. Chen XY, Feng-Chen KC, Chen L, Stark DM, and Wolpaw JR. Short-term and medium-term effects of spinal cord tract transections on soleus H-reflex in freely moving rats. J Neurotrauma 18: 313-327, 2001.
6. Chen XY and Wolpaw JR. Operant conditioning of H-reflex in freely moving rats. J Neurophysiol 73: 411-415, 1995.
7. Chiba A, Oshio K, and Inase M. Magnetically evoked EMGs in rats. Neurol Res 25: 87-91, 2003.
8. Chizh BA, Cumberbatch MJ, Herrero JF, Stirk GC, and Headley PM. Stimulus intensity, cell excitation and the N-methyl-D-aspartate receptor component of sensory responses in the rat spinal cord in vivo. Neuroscience 80: 251-265, 1997.
9. de Leon RD, Tamaki H, Hodgson JA, Roy RR, and Edgerton VR. Hindlimb locomotor and postural training modulates glycinergic inhibition in the spinal cord of the adult spinal cat. J Neurophysiol 82: 359-369, 1999.
10. Delwaide PJ. Human monosynaptic reflexes and presynaptic inhibition: an interpretation of spastic hyperreflexia. In: New Developments in Electromyography and Clinical Neurophysiology, edited by Desmedt JE. Basel: Karger, 1973, p. 508-522.
11. Dietz V. Proprioception and locomotor disorders. Nat Rev Neurosci 3: 781-790, 2002.
12. Dietz V and Colombo G. Recovery from spinal cord injury - underlying mechanisms and efficacy of rehabilitation. Acta Neurochir Suppl 89: 95-100, 2004.
13. Dietz V and Muller R. Degradation of neuronal function following a spinal cord injury: mechanisms and countermeasures. Brain 127: 2221-2231, 2004.
14. Ditunno JF, Little JW, Tessler A, and Burns AS. Spinal shock revisited: a four-phase model. Spinal Cord 42: 383-395, 2004.
15. Douglas JR, Noga BR, Dai X, and Jordan LM. The effects of intrathecal administration of excitatory amino acid agonists and antagonists on the initiation of locomotion in the adult cat. J Neurosci 13: 990-1000, 1993.
16. Edgerton VR, Leon RD, Harkema SJ, Hodgson JA, London N, Reinkensmeyer DJ, Roy RR, Talmadge RJ, Tillakaratne NJ, Timoszyk W, and Tobin A. Retraining the injured spinal cord. J Physiol 533: 15-22, 2001.
17. Faist M, Ertel M, Berger W, and Dietz V. Impaired modulation of quadriceps tendon jerk reflex during spastic gait: differences between spinal and cerebral lesions. Brain 122: 567-579, 1999.
18. Farkas S and Ono H. Participation of NMDA and non-NMDA excitatory amino acid receptors in the mediation of spinal reflex potentials in rats: an in vivo study. Br J Pharmacol 114: 1193-1205, 1995.
19. Feraboli-Lohnherr D, Barthe JY, and Orsal D. Serotonin-induced activation of the network for locomotion in adult spinal rats. J Neurosci Res 55: 87-98, 1999.
20. Fong AJ, Cai LL, Otoshi CK, Reinkensmeyer DJ, Burdick JW, Roy RR, and Edgerton VR. Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training. J Neurosci 25: 11738-11747, 2005.
21. Fouad K, Metz GA, Merkler D, Dietz V, and Schwab ME. Treadmill training in incomplete spinal cord injured rats. Behav Brain Res 115: 107-113, 2000.
22. Gerasimenko YP, Lavrov I, Courtine G, Ichiyama RM, Dy CJ, Zhong H, Roy RR, and Edgerton VR. Spinal cord reflexes induced by epidural spinal cord stimulation in normal awake rats. J Neurosci Methods In press.
23. Hiersemenzel LP, Curt A, and Dietz V. From spinal shock to spasticity: neuronal adaptations to a spinal cord injury. Neurology 54: 1574-1582, 2000.
24. Hultborn H and Malmsten J. Changes in segmental reflexes following chronic spinal cord hemisection in the cat. I. Increased monosynaptic and polysynaptic ventral root discharges. Acta Physiol Scand 119: 405-422, 1983a.
25. Hultborn H and Malmsten J. Changes in segmental reflexes following chronic spinal cord hemisection in the cat. II. Conditioned monosynaptic test reflexes. Acta Physiol Scand 119: 423-433, 1983b.
26. Ichiyama RM, Gerasimenko YP, Zhong H, Roy RR, and Edgerton VR. Hindlimb stepping movements in complete spinal rats induced by epidural spinal cord stimulation. Neurosci Lett 383: 339-344, 2005.
27. Jankowska E, Jukes MG, Lund S, and Lundberg A. The effect of DOPA on the spinal cord. 5. Reciprocal organization of pathways transmitting excitatory action to alpha motoneurones of flexors and extensors. Acta Physiol Scand 70: 369-388, 1967.
28. Jankowska E and Riddell JS. Interneurones mediating presynaptic inhibition of group II muscle afferents in the cat spinal cord. J Physiol 483: 461-471, 1995.
29. Lavrov I, Gerasimenko YP, Ichiyama RM, Courtine G, Zhong H, Roy RR, and Edgerton VR. Evaluation of spinal cord reflex activity in chronically spinalized rats. Soc Neurosci Abstr 865.1, 2005.
30. Lee JK, Emch GS, Johnson CS, and Wrathall JR. Effect of spinal cord injury severity on alterations of the H-reflex. Exp Neurol 196: 430-440, 2005.
31. Leis AA, Kronenberg MF, Stetkarova I, Paske WC, and Stokic DS. Spinal motoneuron excitability after acute spinal cord injury in humans. Neurology 47: 231-237, 1996.
32. LoPachin RM, Gaughan CL, Lehning EJ, Kaneko Y, Kelly TM, and Blight A. Experimental spinal cord injury: spatiotemporal characterization of elemental concentrations and water contents in axons and neuroglia. J Neurophysiol 82: 2143-2153, 1999.
33. Lundberg A. Multisensory control of spinal reflex pathways. Prog Brain Res 50: 11-28, 1979.
34. Malmsten J. Time course of segmental reflex changes after chronic spinal cord hemisection in the rat. Acta Physiol Scand 119: 435-443, 1983.
35. Meinck HM. Occurrence of the H reflex and the F wave in the rat. Electroencephalogr Clin Neurophysiol 41: 530-533, 1976.
36. Nelson SG, Collatos TC, Niechaj A, and Mendell LM. Immediate increase in Ia-motoneuron synaptic transmission caudal to spinal cord transection. J Neurophysiol 42: 655-664, 1979.
37. Nicol DJ, Granat MH, Baxendale RH, and Tuson SJ. Evidence for a human spinal stepping generator. Brain Res 684: 230-232, 1995.
38. Parise M, Garcia-Larrea L, Mertens P, Sindou M, and Mauguiere F. Clinical use of polysynaptic flexion reflexes in the management of spasticity with intrathecal baclofen. Electroencephalogr Clin Neurophysiol 105: 141-148, 1997.
39. Reese NB, Skinner RD, Mitchell D, Yates C, Barnes CN, Kiser TS, and Garcia-Rill E. Restoration of frequency-dependent depression of the H-reflex by passive exercise in spinal rats. Spinal Cord 44: 28 -34, 2006.
40. Roy RR, Hutchison DL, Pierotti DJ, Hodgson JA, and Edgerton VR. EMG patterns of rat ankle extensors and flexors during treadmill locomotion and swimming. J Appl Physiol 70: 2522-2529, 1991.
41. Schindler-Ivens S and Shields RK. Low frequency depression of H-reflexes in humans with acute and chronic spinal-cord injury. Exp Brain Res 133: 233-241, 2000.
42. Schouenborg J. Modular organisation and spinal somatosensory imprinting. Brain Res Brain Res Rev 40: 80-91, 2002.
43. Skinner RD, Houle JD, Reese NB, Berry CL, and Garcia-Rill E. Effects of exercise and fetal spinal cord implants on the H-reflex in chronically spinalized adult rats. Brain Res 729: 127-131, 1996.
44. Talmadge RJ, Roy RR, Caiozzo VJ, and Edgerton VR. Mechanical properties of rat soleus after long-term spinal cord transection. J Appl Physiol 93: 1487-1497, 2002.
45. Taylor S, Ashby P, and Verrier M. Neurophysiological changes following traumatic spinal lesions in man. J Neurol Neurosurg Psychiatry 47: 1102-1108, 1984.
46. Thompson FJ, Reier PJ, Lucas CC, and Parmer R. Altered patterns of reflex excitability subsequent to contusion injury of the rat spinal cord. J Neurophysiol 68: 1473-1486, 1992.
47. Thompson FJ, Reier PJ, Parmer R, and Lucas CC. Inhibitory control of reflex excitability following contusion injury and neural tissue transplantation. Adv Neurol 59: 175-184, 1993.
48. Valero-Cabre A, Fores J, and Navarro X. Reorganization of reflex responses mediated by different afferent sensory fibers after spinal cord transection. J Neurophysiol 91: 2838-2848, 2004.
49. Weaver RA, Landau WM, and Higgins JF. Fusimotor function. II. Evidence of fusimotor depression in human spinal shock. Arch Neurol 9: 127-132, 1963.
50. Wolpaw JR and Chen XY. Operant conditioning of rat H-reflex: effects on mean latency and duration. Exp Brain Res 136: 274-279, 2001.