Restoration of frequency-dependent depression of the H-reflex by passive exercise in spinal rats

Spinal Cord

Volumn 44, Issue 1, 2006, Pages 28-34

  Reese, N B ^a   Skinner, R D ^b   Mitchell, D ^b   Yates, C ^b   Barnes, C N ^b   Kiser, T S ^b   Garcia Rill, E ^b  

^a UNIVERSITY OF CENTRAL ARKANSAS   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Hyper reflexia; Rehabilitation; Spasticity; Spinal cord injury (SCI)

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXERCISE; FEMALE; HINDLIMB; HYPERREFLEXIA; MOBILIZATION; NONHUMAN; PRIORITY JOURNAL; RAT; REFLEX DISORDER; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION; STATISTICAL SIGNIFICANCE; TIME; UNITED STATES; VERTEBRA;

ANIMALS; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; FEMALE; H-REFLEX; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; REFLEX, ABNORMAL; SPINAL CORD; SPINAL CORD INJURIES; TIME FACTORS;

EID: 30344446979     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sj.sc.3101810     Document Type: Article

References (51)

1. Magladery JW, Teasdall RD, Park AM, Languth HW. Electrophysiological studies of reflex activity in patients with lesions of the nervous system. I. A comparison of spinal motoneurone excitability following afferent nerve volleys in normal persons and patients with upper motor neurone lesions. Bull Johns Hopk Hosp 1952; 91: 219-244.
2. Milanov I. Examination of the segmental pathophysiological mechanisms of spasticity. Electromyogr Clin Neurophysiol 1994; 34: 73-79.
3. Laudau WM, Clare MH. Fusimotor function. VI. H-reflex, tendon jerk and reinforcement in hemiplegia. Arch Neurol Psychiat 1964; 10: 128-134.
4. Bennett DJ, Li Y, Harvey PJ, Gorassini M. Evidence for plateau potentials in tail motoneurons of awake chronic spinal rats with spasticity. J Neurophysiol 2001; 86: 1972-1982.
5. Eken T, Hultborn H, Kiehn G. Possible functions of transmitter-controlled plateau potentials in alpha motoneurons. Prog Brain Res 1989; 80: 257-267.
6. Li Y, Bennett DJ. Persistent sodium and calcium currents cause plateau potentials in motoneruons of chronic spinal rats. J Neurophysiol 2003; 90: 857-869.
7. Li Y, Li X, Harvey PJ, Bennett DJ. Effects of baclofen on spinal reflexes and persistent inward currents in motoneurons of chronic spinal rats with spasticty. J Neurophysiol 2004; 92: 2694-2703.
8. Hultborn H. Changes in neuronal properties and spinal reflexes during development of spasticity following spinal cord lesions and stroke: studies in animal models and patients. J Rehab Med 2003; S41: 46-55.
9. Nielsen J, Petersen N, Crone C. Changes in transmission across synapses of Ia afferents in spastic patients. Brain 1995; 118: 995-1004.
10. Little JW, Ditunno JF, Steins SA, Harris RM. Incomplete spinal cord injury: neuronal mechanisms of motor recovery and hyperreflexia. Arch Phys Med Rehab 1999; 80: 587-599.
11. Kitzman P. Alteration in axial motoneuronal morphology in the spinal cord injured spastic rat. Exper Neurol 2005; 192: 100-108.
12. Calancie B et al. Evidence that alterations in presynaptic inhibition contribute to segmental hypo- and hyperexcitability after spinal cord injury in man. Electroencephalogr and Clin Neurophysiol 1993; 89: 177-186.
13. Schindler-Ivens S, Shields RK. Low frequency depression of H-reflexes in humans with acute and chronic spinal-cord injury. Exp Brain Res 2000; 133: 233-241.
14. Pierrot-Deseilligny P. Electrophysiological assessment of the spinal mechanisms underlying spasticity. New Trends Adv Tech Clin Neurophysiol 1990; 41: 264-273.
15. Faist M, Mazevet D, Dietz V, Pierrot-Deseilligny E. A quantitative assessment of presynaptic inhibition of Ia afferents in spastics: differences in hemiplegics and paraplegics. Brain 1994; 117: 1449-1455.
16. Angel RW, Hofmann WW. The H-reflex in normal, spastic, and rigid subjects. Arch Neurol 1963; 8: 591-596.
17. Little JW, Halar EM. H-reflex changes following spinal cord injury. Arch Phys Med Rehab 1985; 66: 19-22.
18. Olsen PZ, Diamantopoulos E. Excitabiliity of spinal motor neurons in normal subjects and patients with spasticity, Parkinsonian rigidity, and cerebellar hypotonia. J Neurol Neurosurg Psychiatry 1967; 30: 325-331.
19. Yablon SA, Stokic DS. Neurophysiologic evaluation of spastic hypertonia. Am J Phys Med Rehab 2004; 83: S10-S18.
20. Thompson FJ, Reier PJ, Lucas CC, Parme R. Altered patterns of reflex excitability subsequent to contusion injury of the rat spinal cord. J Neurophysiol 1992; 68: 1473-1486.
21. Chen XY, Feng-Chen KC, Chen L, Stark DM, Wolpaw JR. Short-term and medium-term effects of spinal cord tract transactions on soleus H-reflex in freely moving rats. J Neurotrauma 2001; 18: 313-327.
22. Ishikawa K, Ott K, Porter RW, Stuart D. Low frequency depression of the H wave in normal and spinal man. Exp Neurol 1966; 15: 140-156.
23. Reese NB et al. Restoration of H-reflex habituation by passive exercise in spinally transected rats. American Phys Ther Assoc Combined Sections Meeting. Nashville, TN 2004.
24. Skinner RD, Houle JD, Reese NB, Berry CL, Garcia-Rill E. Effects of exercise and fetal spinal cord implants on the H-reflex in chronically spinalized adult rats. Brain Res 1996; 729: 127-131.
25. Skinner RD, Houle JD, Reese NB, Dempster J, Garcia-Rill E. Amelioration of the H-reflex in chronically spinalized adult rats by exercise and fetal spinal cord implants. Soc Neurosci Abst 1998; 24: 2103.
26. Meinck HM. Occurrence of the H-reflex and the F wave in the rat. Electroencephalogr Clin Neurophysiol 1976; 41: 530-533.
27. Cliffer KD et al. Consistent repeated M- and H-wave recording in the hind limb of rats. Muscle Nerve 1998; 21: 1405-1413.
28. Kiser TS, Reese NB, Maresh T, Skinner RD, Garcia-Rill E. Exercise-induced normalization of frequency-dependent inhibition of the H-reflex in a spinal cord injured human subject. J Spinal Cord Med in press.
29. Crenna P, Frigo C. Excitability of the soleus H reflex arc during walking and stepping in man. Exp Brain Res 1978; 66: 49-60.
30. Brooke JD, Collins DF, Boucher S, McIlroy W. Modulation of human short latency reflexes between standing and walking. Brain Res 1991; 548: 172-178.
31. Capaday C, Stein RB. Difference in the amplitude of the human soleus H-reflex in walking and running. J Physiol 1987; 392: 513-522.
32. Brooke JD, McIlroy WE, Collins DF. Movement and H reflex modulation. I. Pedalling versus matched controls. Brain Res 1992; 582: 78-84.
33. Thompson FJ, Parmer R, Reier PJ. Alteration in rate modulation of reflexes to lumbar motoneurons after mid thoracic spinal cord injury in the rat. I. Contusion Injury. J Neurotrauma 1998; 15: 495-508.
34. Barbeau H, Rossignol S. Recovery of locomotion after chronic spinalization in the adult cat. Brain Res 1987; 412: 84-95.
35. Lovely RG, Gregor RG, Roy RR, Edgerton VR. Effects of training on the recovery of full-weight-bearing stepping in the adult spinal cat. Exp Neurol 1986; 92: 421-435.
36. de Leon RD, Hodgson JA, Roy RR, Edgerton VR. Locomotor capacity attributable to step training versus spontaneous recovery after spinalization in adult cats. J Neurophysiol 1998; 79: 1329-1340.
37. Little JW, Harris RM, Lerner SJ. Immobilization impairs recovery after spinal cord injury. Arch Phys Med Rehab 1991; 72: 408-412.
38. Trimble MH, Kukulka CG, Behrman AL. The effect of treadmill gait training on low-frequency depressioin of the soleus H-reflex: comparison of a spinal cord injured man to normal subjects. Neurosci Lett 1998; 246: 186-188.
39. Houle JD, Morris K, Skinner RD, Garcia-Rill E, Peterson C. Effects of fetal spinal cord tissue transplants and cycling exercise on the soleus muscle in spinalized rats. Muscle Nerve 1999; 22: 846-856.
40. Yates C, Zhou Y, Mitchell D, Reese NB, Skinner RD, Garcia-Rill E. Motoneuronal coupling after spinal cord injury (SCI) leading to hyperreflexia: increased expression of Connexin 36 (Cx36) in the spinal cord after transection (Tx). Neurosci Abstr in press.
41. Skinner RD, Yates C, Zhou Y, Mitchell D, Reese NB, Garcia-Rill E. Motoneuronal uncoupling by passive exercise in spinal cats: decreased expression of Connexin 36 (Cx36). Neurosci Abstr in press.
42. Walton KD, Navarrete R. Postnatal changes in motoneurone electrotonic coupling studied in the in vitro rat lumbar spinal cord. J Physiol 1991; 433: 283-305.
43. Katz R, Rymer W. Spastic hypertonia: mechanisms and measurement. Arch Phys Med Rehabil 1989; 70: 144-155.
44. Eriksson J, Olausson B, Jankowska E. Antispastic effects of L-dopa. Exp Brain Res 1996; 111: 296-304.
45. Benz EN, Hornby TG, Bode RK, Scheldt RA, Sclimit BD. A physiologically based clinical measure for spastic reflexes in spinal cord injury. Arch Phys Med Rehab 2005; 86: 52-59.
46. Wernig A, Nanassy A, Muller S. Laufband (LB) therapy in spinal cord lesioned persons. Prog Brain Res 2000; 128: 89-97.
47. Wirz M, Colombo G, Dietz V. Long term effects of locomotor training in spinal humans. J Neurol Neurosurg Psychiatry 2001; 71: 93-96.
48. Sadowsky CL. Electrical stimulation in spinal cord injury. Neurorehabilitation 2001; 16: 165-169.
49. Wieler M et al. Multicenter evaluation of electrical stimulation systems for walking. Arch Phys Med Rehab 1999; 80: 495-500.
50. Barbeau H, Norman KE. The effect of noradrenergic damage on the recovery of walking after spinal cord injury. Spinal Cord 2003; 41: 137-143.
51. Dietz V, Miller R, Colombo G. Locomotor activity in spinal man: significance of afferent input from joint and load receptors. Brain 2002; 125: 2626-2634.