Evidence for a chromosome 2p13-14 schizophrenia susceptibility locus in families from Palau, Micronesia

Molecular Psychiatry

Volumn 3, Issue 6, 1998, Pages 521-527

  Coon, H ^a   Myles Worsley, M ^b   Tiobech, J ^c   Hoff, M ^a   Rosenthal, J ^b   Bennett, P ^c   Reimherr, F ^a   Wender, P ^b   Dale, P ^c   Polloi, A ^a   Byerley, W ^a,d  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b Belau National Hospital   (Federated States of Micronesia)

^c UNIVERSITY OF HAWAII   (United States)

^d UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

Chromosome 2p; Extended pedigrees; Linkage; Population isolate; Schizophrenia

Indexed keywords

MICROSATELLITE DNA;

ADULT; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CHROMOSOME 2P; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PEDIGREE; PRIORITY JOURNAL; SCHIZOPHRENIA;

EID: 18244423475     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000453     Document Type: Article

References (35)

1. Jablensky A, Sartorius N, Ernberg G, Anker M, Körten A, Cooper JE et al. Schizophrenia: manifestations, incidence and course in different cultures. Psychol Med 1992; 22 [Monograph Suppl 20]: 1-97.
2. Gottesman II. Schizophrenia Genesis: The Origins of Madness. WH Freeman: New York, 1991.
3. Risch N. Genetic linkage and complex diseases, with special reference to psychiatric disorders. Genet Epidemiol 1990; 7: 3-16.
4. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994; 371: 130-136.
5. Todd JA, Farrall M. Panning for gold: genome-wide scanning for linkage in type 1 diabetes. Hum Molec Genet 1996; 5: 1443-1448.
6. Smith JR, Freije D, Carpten JD, Gronberg H, Xu J, Isaacs SD et al. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science 1996; 274:1371-1374.
7. Wang S, Sun C, Walczak CA, Ziegle JS, Kipps BR, Goldin LR et al. Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22. Nature Genet 1995; 10: 41-46.
8. Sträub R, MacLean C, O'Niell FA, Burke J, Murphy B, Duke F et al. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nature Genet 1995; 11: 287-293.
9. Schellenberg GD, Bird TD, Wijsman EM, Orr HT, Anderson L, Nemens E et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 1992; 258: 668-672.
10. Polymeropoulos MH, Higgins JJ, Golbe LI, Johnson WG, Ide SE, Di lorio G et al. Mapping of a gene for Parkinson's disease to chromosome 4q21-q23. Science 1996; 274: 1197-1199.
11. Book JA, Wetterberg L, Modrzewska K. Schizophrenia in a North Swedish geographical isolate, 1900-1977: epidemiology, genetics, and biochemistry, din Genet 1978; 14: 373-394.
12. Parmentier RJ. The Sacred Remains, Myth, History and Polity in Belau. University of Chicago Press: Chicago, 1987.
13. Takayama J. Early pottery and population movements in Micronesian prehistory. Asian Perspectives 1981; 24: 1-10.
14. Jorde LB. Invited editorial: linkage disequilibrium as a gene-mapping tool. Am J Hum Genet 1995; 5G: 11-14.
15. Endicott J, Spitzer RL. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psych 1978; 35: 837-844.
16. Spitzer RL, Endicott J, Robins E. Research diagnostic criteria. Arch Gen Psych 1978; 35: 773-782.
17. Myles-Worsley M, Coon H, Tiobech J, Collier J, Dale P, Wender P et al. A genetic epidemiological study of schizophrenia in Palau, Micronesia: I. prevalence and familiality. Neuropsychiat Genet (in press).
18. Bell G, Karam J, Rutter W. Polymorphic DNA region adjacent to the 5' end of the human insulin gene. Proc NatI Acad Sci USA 1981; 78: 5759-5763.
19. Cooperative Human Linkage Center (CHLC): Genethon, University of Utah, Yale University, and Centre d'Etude du Polymorphisme Humain. A comprehensive human linkage map with centiMorgan density. Science 1994; 265: 2049-2054.
20. Saccone S, Desario A, Dellavalle G, Bernard! G. The highest concentrations in the human genome are in telomeric bands of metaphase chromosomes. Proc Natl Acad Sci USA 1992; 89: 4913-4917.
21. Coon H, Jensen S, Holik J, Hoff M, Myles-Worsley M, Reimherr F et al. Genomic scan for genes predisposing to schizophrenia. Am J Med Genet 1994; 54: 59-71.
22. Hasstedt S, Cartwright P. PAP: Pedigree Analysis Package, Computing and Technical Report 13, Salt Lake City. Department of Medical Biophysics and Computing, University of Utah, 1979.
23. Cottingham RW, Idury RM, Schaffer AA. Faster sequential genetic linkage computations. Am J Hum Genet 1993; 53: 252-263.
24. Lathrop GM, Lalouel J-M, Julier C, Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 1984; 81: 3443-3446.
25. Weeks DE, Lange K. The Affected-Pedigree-Member method of linkage analysis. Am J Hum Genet 1988; 42: 315-326.
26. OU J. Computer-simulation methods in human linkage analysis. Proc Natl Acad Sci USA 1989; 86: 4175-4178.
27. Weeks DE, Ott J, Lathrop GM. SLINK: a general simulation program for linkage analysis. Am f Hum Genet 1990; 47: A204 (supplement).
28. Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A el al. A comprehensive genetic map of the human genome based on 5264 microsatellites. Nature 1996; 380: 152-154.
29. Ott J. Analysis of Human Genetic Linkage, rev edn. Johns Hopkins University Press: Baltimore, 1991.
30. Hästbacka J, de la Chapelle A, Kaitila I, Sistonen P, Weaver A, Lander E. Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland. Nature Genet 1992; 2: 204-211.
31. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 1996; 58: 1347-1363.
32. DeLisi L. A genome scan of schizophrenia. Results presented at the 1997 Park City Molecular Psychiatry Conference, Park City, Utah, February 1997.
33. Faraone SV, Matise T, Svrakic D, Pepple J, Malaspina D, Suarez B et al. Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium. AmJMed Genet 1998; 81: 290-295.
34. Moises HW, Yang L, Kristbjarnarson H, Wiese C, Byerley W, Macciardi F et al An international two-stage genome-wide search for schizophrenia susceptibility genes. Nature Genet 1995; 11: 321324.
35. Levinson DF, Mahtani MM, Drown D, Nancarrow DJ, Kirby A, Daly M et al. Genome scan of schizophrenia. Am J Psychiatry 1998; 155: 741-750.