Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512

Metabolic Engineering

Volumn 8, Issue 6, 2006, Pages 653-661

  Freitag, Anja ^a   Méndez, Carmen ^b   Salas, José A ^b   Kammerer, Bernd ^a   Li, Shu Ming ^a   Heide, Lutz ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

Author keywords

Aminocoumarin; Antibiotic; Biosynthesis; Deoxysugar; Metabolic engineering; Streptomyces

Indexed keywords

BACTERIAL GYRASE; CLOROBIOCIN; ELLORAMYCIN; STREPTOMYCES; STREPTOMYCES COELICOLOR M512;

BACTERIA; BIOCHEMICAL ENGINEERING; BIOSYNTHESIS; GENES; METABOLISM;

DERIVATIVES;

4 KETOREDUCTASE; ANTIBIOTIC AGENT; CLOROBIOCIN; DEOXYSUGAR; ENZYME; GLYCOSIDE; NOVCLOBIOCIN 122; NOVCLOBIOCIN 123; OLEANDOMYCIN; RHAMNOSE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG SYNTHESIS; EPIMERIZATION; GENE CLUSTER; GENE EXPRESSION; GLYCOSYLATION; METABOLIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES COELICOLOR;

AMINOCOUMARINS; ANTHRAQUINONES; BIOREACTORS; BIOSYNTHETIC PATHWAYS; BIOTECHNOLOGY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENE DELETION; GENETIC ENGINEERING; METHYLTRANSFERASES; NOVOBIOCIN; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLASMIDS; STREPTOMYCES COELICOLOR;

BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES COELICOLOR;

EID: 33749434635     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2006.07.003     Document Type: Article

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