Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 4, 2006, Pages

  Lourenço, André P ^a   Roncon Albuquerque Jr , Roberto ^a   Brás Silva, Carmen ^a   Faria, Bernardo ^a   Wieland, Joris ^a   Henriques Coelho, Tiago ^a   Correia Pinto, Jorge ^a   Leite Moreira, Adelino F ^a  

^a University of Porto   (Portugal)

Author keywords

Endothelin 1; Gene expression; Heart; Myocardial contractility; Neuroendocrine stimulation

Indexed keywords

BOSENTAN; BRAIN NATRIURETIC PEPTIDE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIN 1; MESSENGER RNA; MONOCROTALINE; NEUROHORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; GENE EXPRESSION; HEART DISEASE; HEART FUNCTION; HEART HEMODYNAMICS; HEART INDEX; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE MUSCLE; HEART LEFT VENTRICLE OVERLOAD; HEART LEFT VENTRICLE RELAXATION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HISTOPATHOLOGY; INOTROPISM; MALE; NEUROENDOCRINE SYSTEM; NONHUMAN; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; UPREGULATION;

ALDOSTERONE SYNTHASE; ANGIOTENSINOGEN; ANIMALS; ANTIHYPERTENSIVE AGENTS; ENDOTHELIN-1; GENE EXPRESSION REGULATION; HEART VENTRICLES; HEMODYNAMIC PROCESSES; HYPERTENSION, PULMONARY; MALE; MONOCROTALINE; MYOCARDIAL CONTRACTION; NATRIURETIC PEPTIDE, BRAIN; NEUROTRANSMITTER AGENTS; PEPTIDES, CYCLIC; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, WISTAR; RNA, MESSENGER; SULFONAMIDES; VENTRICULAR REMODELING;

EID: 33749365318     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01004.2005     Document Type: Article

References (38)

1. Brauchlin AE, Soccal PM, Rochat T, Spiliopoulos A, Nicod LP, and Trindade PT. Severe left ventricular dysfunction secondary to primary pulmonary hypertension: Bridging therapy with bosentan before lung transplantation. J Heart Lung Transplant 24: 777-780, 2005.
2. Brunner F. Cardiac endothelin and big endothelin in right-heart hypertrophy due to monocrotaline-induced pulmonary hypertension in rat. Cardiovasc Res 44: 197-206, 1999.
3. Correia-Pinto J, Henriques-Coelho T, Oliveira SM, and Leite-Moreira AF. Distinct load dependence of relaxation rate and diastolic function in Oryctolagus cuniculus and Ratus norvegicus. J Comp Physiol [B] 173: 401-407, 2003.
4. Dong SJ, Crawley AP, MacGregor JH, Petrank YF, Bergman DW, Belenkie I, Smith ER, Tyberg JV, and Beyar R. Regional left ventricular systolic function in relation to the cavity geometry in patients with chronic right ventricular pressure overload. Circulation 91: 2359-2370, 1995.
5. Endoh M. Force-frequency relationship in intact mammalian ventricular myocardium: physiological and pathophysiological relevance. Eur J Pharmacol 500: 73-86, 2004.
6. Fujisaki H, Ito H, Hirata Y, Tanaka M, Hata M, Lin M, Adachi S, Akimoto H, Marumo F, and Hiroe M. Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression. J Clin Invest 96: 1059-1065, 1995.
7. Gomez A, Unruh H, and Mink S. Left ventricular systolic performance is depressed in chronic pulmonary emphysema in dogs. Am J Physiol Heart Circ Physiol 267: H232-H247, 1994.
8. Henriques-Coelho T, Correia-Pinto J, Roncon-Albuquerque R Jr, Baptista MJ, Lourenço AP, Oliveira SM, Brandão-Nogueira A, Teles A, Fortunato JM, and Leite-Moreira AF. Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 287: H2885-H2890, 2004.
9. Hill NS, Warburton RR, Pietras L, and Klinger JR. Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats. J Appl Physiol 83: 1209-1215, 1997.
10. Ichikawa KI, Hidai C, Okuda C, Kimata SI, Matsuoka R, Hosoda S, Quertermous T, and Kawana M. Endogenous endothelin-1 mediates cardiac hypertrophy and switching of myosin heavy chain gene expression in rat ventricular myocardium. J Am Coll Cardiol 27: 1286-1291, 1996.
11. Ishikawa S, Honda M, Yamada S, Goto Y, Morioka S, Ishinaga Y, Murakami Y, Masumura S, and Moriyama K. Different biventricular remodeling of myosin and collagen in pulmonary hypertension. Clin Exp Pharmacol Physiol 19: 723-732, 1992.
12. Ito H, Hirata Y, Adachi S, Tanaka M, Tsujino M, Koike A, Nogami A, Murumo F, and Hiroe M. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest 92: 398-403, 1993.
13. Iwanaga Y, Kihara Y, Hasegawa K, Inagaki K, Yoneda T, Kaburagi S, Araki M, and Sasayama S. Cardiac endothelin-1 plays a critical role in the functional deterioration of left ventricles during the transition from compensatory hypertrophy to congestive heart failure in salt-sensitive hypertensive rats. Circulation 98: 2065-2073, 1998.
14. A antagonist in rats with monocrotaline-induced pulmonary hypertension. Circulation 103: 314-318, 2001.
15. Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, and Yamaguchi I. Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1α induced for impaired myocardial energy metabolism. Circulation 103: 2387-2394, 2001.
16. Kögler H, Hartmann O, Leineweber K, Nguyen van P, Schott P, Brodde OE, and Hasenfuss G. Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat. Circ Res 93: 230-237, 2003.
17. Koide M, Carabello BA, Conrad CC, Buckley JM, DeFreyte G, Barnes M, Tomanek RJ, Wei CC, Dell'Italia LJ, Cooper GIV, and Zile MR. Hypertrophic response to hemodynamic overload: role of load vs. renin-angiotensin system activation. Am J Physiol Heart Circ Physiol 276: H350-H358, 1999.
18. Leineweber K, Brandt K, Wludyka B, Beilfuß A, Pönicke K, Heinroth-Hoffmann I, and Brodde OE. Ventricular hypertrophy plus neuro-humoral activation is necessary to alter the cardiac β-adrenoceptor system in experimental heart failure. Circ Res 91: 1056-1062, 2002.
19. B receptor stimulation and their modulation by endocardial endothelium, NO, and prostaglandins. Am J Physiol Heart Circ Physiol 287: H1194-H1199, 2004.
20. Leite-Moreira AF and Correia-Pinto J. Load as an acute determinant of end-diastolic pressure-volume relation. Am J Physiol Heart Circ Physiol 280: H51-H59, 2001.
21. Lisy O, Redfield MM, Jovanovic S, Jougasaki M, Jovanovic A, Leskinen H, Terzic A, and Burnett JC Jr. Mechanical unloading versus neurohumoral stimulation on myocardial structure and endocrine function In vivo. Circulation 102: 338-343, 2000.
22. Menzel T, Wagner S, Kramm T, Mohr-Kahaly S, Mayer E, Braeuninger S, and Meyer J. Pathophysiology of impaired right and left ventricular function in chronic embolic pulmonary hypertension. Changes after pulmonary thromboendarterectomy. Chest 118: 897-903, 2000.
23. Meyrick B, Gamble W, and Reid L. Development of Crotalaria pulmonary hypertension: hemodynamic and structural study. Am J Physiol Heart Circ Physiol 239: H692-H702, 1980.
24. Miyauchi T, Yorikane R, Sakai S, Sakurai T, Okada M, Nishikibe M, Yano M, Yamaguchi I, Sugishita Y, and Goto K. Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension. Circ Res 73: 887-897, 1993.
25. Molteni A, Ward WF, Ts'ao CH, Port CD, and Solliday NH. Monocrotaline-induced pulmonary endothelial dysfunction in rats. Proc Soc Exp Biol Med 176: 88-94, 1984.
26. Onishi K, Ohno M, Little WC, and Cheng CP. Endogenous endothelin-1 depresses left ventricular systolic and diastolic performance in congestive heart failure. J Pharmacol Exp Ther 288: 1214-1222, 1999.
27. Pielsticker EJ, Martinez FJ, and Rubenfire M. Lung and heart-lung transplant practice patterns in pulmonary hypertension centers. J Heart Lung Transplant 20: 1297-1304, 2001.
28. 2+ uptake. Circulation 102: 1582-1588, 2000.
29. Schena M, Clini E, Errera D, and Quadri A. Echo-Doppler evaluation of left ventricular impairment in chronic cor pulmonale. Chest 109: 1446-1451, 1996.
30. Schott P, Singer SS, Kögler H, Neddermeier D, Leineweber K, Brodde OE, Regitz-Zagrosek V, Schmidt B, Dihazi H, and Hasenfuss G. Pressure overload and neurohumoral activation differentially affect the myocardial proteome. Proteomics 5: 1372-1381, 2005.
31. Seyfarth T, Gerbershagen HP, Giessler C, Leineweber K, Heinroth-Hoffman I, Pönicke K, and Brodde OE. The cardiac -adrenoceptor-G-protein(s)- adenylyl cyclase system in monocrotaline treated rats. J Mol Cell Cardiol 32: 2315-2326, 2000.
32. Sharma S, Taegtmeyer H, Adrogue J, Razeghi P, Sen S, Ngumbela K, and Essop MF. Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy. Am J Physiol Heart Circ Physiol 286: H1185-H1192, 2004.
33. Slinker BA and Glantz SA. End-systolic and end-diastolic ventricular interaction. Am J Physiol Heart Circ Physiol 251: H1062-H1075, 1986.
34. Versluis JP, Heslinga JW, Sipkema P, and Westerhof N. Contractile reserve but not tension is reduced in monocrotaline-induced right ventricular hypertrophy. Am J Physiol Heart Circ Physiol 286: H979-H984, 2004.
35. Werchan PM, Summer WR, Gerdes AM, and McDonough KM. Right ventricular performance after monocrotaline-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 256: H1328-H1336, 1989.
36. Xie GY, Lin CS, Preston HM, Taylor CG, Kearney K, Sapin PM, and Smith MD. Assessment of left ventricular diastolic function after single lung transplantation in patients with severe pulmonary hypertension. Chest 114: 477-481, 1998.
37. A receptor antagonist YM598 prevents and reverses the development of pulmonary hypertension in monocrotaline-treated rats. Eur J Pharmacol 496: 129-139, 2004.
38. Zolk O, Munzel F, and Eschenhagen T. Effects of chronic endothelin-1 stimulation on cardiac myocyte contractile function. Am J Physiol Heart Circ Physiol 286: H1248-H1257, 2004.