Mycoplasma fermentans and TNF-β interact to amplify immune-modulating cytokines in human lung fibroblasts

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 291, Issue 4, 2006, Pages

  Fabisiak, James P ^a   Gao, Fei ^a   Thomson, Robyn G ^a   Strieter, Robert M ^b   Watkins, Simon C ^a   Dauber, James H ^a  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chemokines; Host defense; Innate immunity; Interleukin 6; Toll like receptors

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LYMPHOTOXIN; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; MELANOMA GROWTH STIMULATORY ACTIVITY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 6; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DNA BINDING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; IN VITRO STUDY; LUNG ALVEOLUS CELL; LUNG FIBROBLAST; MYCOPLASMA FERMENTANS; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL;

CELLS, CULTURED; CYTOKINES; FIBROBLASTS; HUMANS; IMMUNOLOGIC FACTORS; LUNG; LUNG DISEASES; LYMPHOTOXIN-ALPHA; MITOGEN-ACTIVATED PROTEIN KINASES; MYCOPLASMA FERMENTANS; MYCOPLASMA INFECTIONS; NF-KAPPA B; OLIGOPEPTIDES; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 6;

EID: 33749322191     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00031.2006     Document Type: Article

References (53)

1. Ainsworth JG, Hourshid S, Webster AD, Gilroy CB, and Taylor-Robinson D. Detection of Mycoplasma fermentans in healthy students and patients with congenital immunodeficiency. J Infect 40: 138-140, 2000.
2. Ammit AJ, Lazaar AL, Irani C, O'Neill GM, Gordon ND, Amrani Y, Penn RB, and Panettieri RA Jr. Tumor necrosis factor-α-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells. Modulation by glucocorticoids and β-agonists. Am J Respir Cell Mol Biol 26: 465-474, 2002.
3. Andoh A, Fujino S, Bamba S, Araki Y, Okuno T, Bamba T, and Fujiyama Y. IL-17 selectively down-regulates TNF-α-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol 169: 163-1687, 2002.
4. Barchowsky A, Frleta D, and Vincenti MP. Integration of NF-κB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts. Cytokine 12: 1469-1479, 2000.
5. Baseman JB and Tully JG. Mycoplasmas: sophisticated, reemerging, and burdened by their notoriety. Emerg Infect Dis 3: 21-32, 1997.
6. Belperio JA, Keane MP, Burdick MD, Londhe V, Xue YY, Li K, Phillips RJ, and Strieter RM. Critical role of CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. J Clin Invest 110: 1703-1716, 2002.
7. Cassell GH. Infectious causes of chronic inflammatory diseases and cancer. Emerg Infect Dis 4: 475-487, 1998.
8. Cesarone CF, Bolognesi L, and Santi L. Improved microfluorometric DNA determination in biological material using 33258 Hoechst. Anal Biochem 100: 188-197, 1979.
9. Chanock RM, Hayflick L, and Barile MF. Growth on artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO. Proc Natl Acad Sci USA 48: 41-49, 1962.
10. Choppa PC, Vojdani A, Tagle C, Andrin R, and Magtolo L. Multiplex PCR for the detection of Mycoplasma fermentans, M. hominis, and M penetrans in cell cultures and blood samples of patients with chronic fatigue syndrome. Mol Cell Probes 12: 301-308, 1998.
11. Diehl S, Chow CW, Weiss L, Palmetshofer A, Twardzik T, Rounds L, Serfling E, Davis RJ, Anguita J, and Rincon M. Induction of NFATc2 expression by interleukin 6 promotes T helper Type 2 differentiation. J Exp Med 196: 39-49, 2002.
12. Dignam JD, Lebovitz RM, and Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extraction isolated from mammalian nuclei. Nucleic Acids Res 11: 1475-1489, 1983.
13. Elias JA, Trincheri G, Beck JM, Simon PL, Sehgal PB, May LT, and Kern JA. A synergistic interaction of IL-6 and IL-1 mediates the thymocyte-stimulating activity produced by recombinant IL-1-stimulated fibroblasts. J Immunol 142: 509-514, 1989.
14. Fabisiak JP, Absher M, Evans JN, and Kelley J. Spontaneous production of platelet-derived growth factor A-chain homodimer (PDGF-AA) by rat lung fibroblasts in vitro. Am J Physiol Lung Cell Mol Physiol 263: L185-L193, 1992.
15. Fabisiak JP, Weiss RD, Powell GA, and Dauber JH. Enhanced secretion of immune-modulating cytokines by human lung fibroblasts during in vitro infection with Mycoplasma fermentans. Am J Respir Cell Mol Biol 8: 358-364, 1993.
16. Galanos C, Gumenscheimer M, Muhlradt P, Jirillo E, and Freudenberg M. MALP-2, a mycoplasma lipopeptide with classical endotoxic properties: end of an era of LPS monopoly. J Endotoxin Res 6: 471-476, 2000.
17. Gao F, Barchowsky A, Nemec AA, and Fabisiak JP. Microbial stimulation by Mycoplasma fermentans synergistically amplifies IL-6 release by human lung fibroblasts in response to residual oil fly ash (ROFA) and nickel. Tox Sci 81: 467-479, 2004.
18. Garcia J, Lemercier B, Roman-Roman S, and Rawadi G. A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-κB and cytokine secretion in macrophages via activation of mitogen-activated protein kinase pathways. J Biol Chem 273: 34391-34398, 1998.
19. Grimm S and Baeurle PA. The inducible transcription factor NF-κB: structure-function relationship of its subunits. Biochem J 290: 297-308, 1993.
20. Horowitz S, Evinson B, Borer A, and Horowitz J. Mycoplasma fermentans in rheumatoid arthritis and other inflammatory arthritides. J Rheumatol 27: 2747-2753, 2000.
21. Jijon HB, Paneka WJ, Madsen KL, and Parsons HG. MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a postranscriptional mechanism. Am J Physiol Cell Physiol 283: C31-C41, 2002.
22. Kovacic R, Launay V, Tuppin P, Lafeuillade A, Feuillie V, Montagnier L, and Grau O. Search for the presence of six Mycoplasma species in peripheral blood mononuclear cells of subjects seropositive and seronegative for human immunodeficiency virus. J Clin Microbiol 34: 1808-1810, 1996.
23. Kraft M, Casell GH, Hensen JE, Watson H, Williamson J, Marimion BP, Gaydos CA, and Martin RJ. Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma. Am J Respir Crit Care Med 158: 998-1001, 1998.
24. Kraft M, Cassell GH, Pak J, and Martin RJ. Mycoplasma pneumoniae and Chlamydia pneumoniae in asthma: effect of clarithromycin. Chest 121: 1782-1788, 2002.
25. Lo SC, Dawson MS, Wong DM, Newton PB, Sonoda MA III, Engler WF, Wang RYH, Alter HJ, and Wear DJ. Identification of Mycoplasma incognitus infection in patients with AIDS: an immunohistochemical, in situ hybridization, and ultrastructural study. Am J Trop Med Hyg 41: 601-616, 1989.
26. Muhlradt PF, Keiss M, Meyer H, Sussmuth R, and Jung G. Isolation, structural elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentrations. J Exp Med 185: 1951-1958, 1997.
27. Muhlradt PF, Quentmeier H, and Schmitt E. Involvement of interleukin-1 (IL-1), IL-6, IL-2, and IL-4 in the generation of cytolytic T cells from thymocytes stimulated by a Mycoplasma fermentans-derived product. Infect Immun 59: 3962-3968, 1991.
28. Murphy WH, Bullis C, Dabich L, Heyn R, and Zarafonetis JD. Isolation of mycoplasma from leukemic and nonleukemic patients. J Natl Cancer Inst 45: 243-251, 1970.
29. Nishiguchi M, Matsumoto M, Takao T, Hoshino M, Shimonishi Y, Tsuji S, Begum NA, Takeuchi O, Akira S, Toyoshima K, and Seya T. Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by Toll-like receptor 2: role of N-terminal hydrophobic portion in its multiple functions. J Immunol 166: 2610-2616, 2001.
30. Nonaka M, Pawankar R, Saji F, and Yagi T. Distinct expression of RANTES and GM-CSF by lipopolysaccharide in human nasal fibroblasts but not in other airway fibroblasts. Int Arch Allergy Immunol 119: 314-321, 1999.
31. Ohshima S, Saeki Y, Mima T, Sasai M, Nishioka K, Nomura S, Kopf M, Katada Y, Tanaka T, Suemara M, and Kishimoto T. Interleukin-6 plays a key role in the development of antigen-induced arthritis. Proc Natl Acad Sci USA 95: 8222-8226, 1998.
32. O'Neill L. The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defense. Biochem Soc Trans 28: 557-563, 2000.
33. Ozcan SA and Miles R. Biochemical diversity of Mycoplasma fermentans strains. FEMS Microbiol Lett 176: 177-181, 1999.
34. Quentmeier H, Schmidt E, Kirchhoff H, Grote W, and Mulradt PF. Mycoplasma fermentans-derived high-molecular weight material induces interleukin-6 release in cultures of murine macrophages and human monocytes. Infect Immun 58: 1273-1280, 1990.
35. Rawadi G and Roman-Roman S. Mycoplasma membrane lipoproteins induce proinflammatory cytokines by a mechanism distinct from that of lipopolysaccharide. Infect Immun 64: 637-643, 1996.
36. Rodwell AW and Whitcomb RH. Methods for direct and indirect measurement of mycoplasma growth. In: Methods in Mycoplasmology, edited by Tully JG and Razin S. New York: Academic, 1983, p. 185-196.
37. Ruiter M and Wentholt HMM. A pleuropneumonia-like organism in primary fusopirochetal gangrene of the penis. J Invest Dermatol 15: 301-304, 1950.
38. Rupp J, Hellwig-Burgel T, Wobbe V, Seitzer U, Brandt F, and Maass M. Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo. Proc Natl Acad Sci USA 102: 3447-3452, 2005.
39. Saillard C, Carle P, Bove JM, Bebear C, Lo SC, Shih JWK, Wang RYH, Rose DL, and Tully JG. Genetic and serologic relatedness between M. fermentans and a mycoplasma recently identified in tissues of AIDS and non-AIDS patients. Res Virol 141: 441-448, 1990.
40. Shibata K, Kaga M, Kudo M, Dong L, Hasebe A, Domon H, Sato Y, Oguchi H, and Watanabe T. Detection of Mycoplasma fermentans in saliva sampled from infants, preschool, and school children, adolescents and adults by a polymerase chain reaction-based assay. Microbiol Immunol 43: 521-525, 1999.
41. Strieter RM, Belperio JA, and Keane MP. Cytokines in innate host defense in the lung. J Clin Invest 109: 699-705, 2002.
42. Taylor-Robinson D. Infections due to species of mycoplasma and ureaplasma: an update. Clin Infect Dis 23: 671-684, 1996.
43. Taylor-Robinson D. Mycoplasmas in rheumatoid arthritis and other human arthritides. J Clin Pathol 49: 781-782, 1996.
44. Tsai S, Wear DJ, Shih JWK, and Lo SC. Mycoplasmas and oncogenesis: Persistent infection and multistage malignant transformation. Proc Natl Acad Sci USA 92: 10197-10201, 1995.
45. Tully JG, Whitcomb RF, Clark HF, and Williamson DL. Pathogenic mycoplasmas: cultivation and vertebrate pathogenicity of a new spiroplasma. Science 195: 892-894, 1977.
46. Vancheri C, Gauldie J, Beinenstock J, Cox R, Scicchitano R, Stanisz A, and Jordana M. Human lung fibroblast-derived granuolocyte-macrophage colony-stimulating factor (GM-CSF) mediates eosinophil survival in vitro. Am J Respir Cell Mol Biol 1: 289-295, 1989.
47. Vojdani A, Choppa PC, Tagle C, Andrin R, Samimi B, and Lapp CW. Detection of Mycoplasma genus and Mycoplasma fermentans by PCR in patients with chronic fatigue syndrome. FEMS Immunol Med Microbiol 22: 355-365, 1998.
48. Wang RYH, Hu WS, Dawson MS, Shih JWK, and Lo SC. Selective detection of Mycoplasma fermentans by polymerase chain reaction and by using a nucleotide sequence with the insertion sequence-like element. J Clin Microbiol 30: 245-248, 1992.
49. Ward NS, Waxman AB, Homer RJ, Mantell LL, Einarsson O, Du YF, and Elias JA. Interleukin-6-induced protection in hyperoxic acute lung injury. Am J Respir Cell Mol Biol 22: 535-542, 2000.
50. Winzen R, Kracht M, Ritter B, Wilhelm A, Chen AYA, Shyum AB, Muller M, Gaestel M, Resch K, and Holtmann H. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP-kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J 18: 4969-4980, 1999.
51. Xing Z, Gauldie J, Cox H, Baumann H, Jordana M, Lei XF, and Achong MK. IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 101: 311-320, 1998.
52. Xing Z, Jordana M, Braciak T, Ohtoshi T, and Gauldie J. Lipopolysaccharide induces expression of granulocyte/macrophage colony-stimulating factor, interleukin-8, and interleukin-6 in human nasal, but not lung fibroblasts: evidence of heterogeneity within the respiratory tract. Am J Respir Cell Mol Biol 9: 255-263, 1993.
53. Yang J, Hooper WC, Phillips DJ, and Talkington DF. Cytokines in Mycoplasma pneumoniae infections. Cytokine Growth Factor Rev 15: 157-1368, 2004.